The Lancet Commission on Prostate Cancer has warned of an inevitable global surge in prostate cancer cases, with a doubling to 2.9 million cases by 2040. This acceleration is already happening in high-income countries and will spread to low- and medium-income countries. The commission recommends screening for men aged 50-70, with a focus on harm-reduction strategies for PSA screening. Undertreatment of advanced cases is a concern, especially in men of African ancestry. New approaches are needed for earlier diagnosis in low- to middle-income countries. Pop-up clinics and mobile testing are recommended. The medical community is ill-prepared for the increase in cases, with potential solutions including increased use of nurses and artificial intelligence.
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