New genetic variants could raise a woman’s risk of cervical cancer from HPV infections

Human papillomavirus (HPV) is a common cancer-causing virus that can lead to cervical cancer if infections persist. A study led by University of Maryland School of Medicine researchers identified genetic variants in certain women that increase the risk of persistent HPV infections and cervical cancer. These findings were published in The European Journal of Human Genetics. The study involved over 10,000 women, with specific genetic variants linked to prevalent and persistent high-risk HPV infections. The research team developed polygenic risk scores to assess the likelihood of developing these infections. The findings could help in personalized cervical cancer prevention strategies.

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