Intestinal neurons in infancy could explain wide-ranging gastrointestinal disorders in children

A new theory proposed by Wu Tsai Neuro Faculty Scholar Julia Kaltschmidt and MD/Ph.D. candidate Lori Dershowitz suggests that defects in the organization of gut neurons in infancy may be linked to pediatric gastrointestinal motility disorders. This theory, published in a Perspective article in the journal Cellular and Molecular Gastroenterology and Hepatology, highlights the importance of the enteric nervous system (ENS) in regulating GI tract function. The researchers suggest that changes in the striped patterning of enteric neurons could explain various structural pathologies observed in GI disorders, leading to potential improvements in diagnostic methods and treatments for affected children and families.

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