Heart disease and depression may be genetically linked by inflammation

Coronary artery disease and major depression may be linked genetically through inflammatory pathways, leading to an increased risk for cardiomyopathy. Researchers at Vanderbilt University Medical Center and Massachusetts General Hospital found that drugs used to treat both conditions may reduce inflammation and prevent the development of cardiomyopathy. The study identified 185 genes associated with both depression and CAD, enriched for inflammation and cardiomyopathy. While patients with these genes had a lower incidence of cardiomyopathy, medications for CAD and depression may prevent its development by reducing inflammation. Further research is needed to explore optimal treatment mechanisms for managing both conditions.

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