Researchers in a study published in Nature found that DNA damage in the hippocampus neurons during learning triggers a cascade of molecular events leading to memory formation. The study focused on the role of toll-like receptor 9 (TLR9) in repairing the double-stranded DNA damage in neuronal clusters. Transcriptional profiles were analyzed in murine models subjected to contextual fear conditioning. Results showed DNA damage followed by TLR9 activation, which is crucial for memory formation. Impairments in TLR9 function could lead to cognitive disorders. The study highlights the importance of TLR9-mediated DNA repair in the formation of memory circuits in the hippocampus.
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DNA repair process key to memory formation, study finds
