Community-Acquired Urinary Tract Infection: Adverse Effects of Cotrimoxazole vs Fluoroquinolones

A study published in Infectious Diseases Now compared the treatment of community-acquired urinary tract infections (cUTI) with cotrimoxazole vs fluoroquinolones. Among 640 patients with cUTI due to Enterobacteriaceae, those treated with cotrimoxazole experienced more adverse effects and longer hospital stays compared to those treated with fluoroquinolones. The study also found that the use of broad-spectrum antibiotics like cotrimoxazole may lead to the emergence of multidrug-resistant bacteria. Further research is needed to determine the cost effectiveness of using cotrimoxazole as a prioritized antibiotic therapy for cUTI. The study authors suggest that such antibiotic strategies may have unintended consequences for patients and the healthcare system.

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