To Operate or Not on Adults With Uncomplicated Appendicitis?

A meta-analysis of randomized controlled trials on the use of antibiotic therapy versus surgical treatment for uncomplicated adult appendicitis was conducted to assess safety, cost, and efficacy. Results showed a primary failure rate of 29.5% with antibiotics, increasing to 35.6% at 1 year, but no significant differences in complications or hospital stay compared to surgery. Cost analysis favored antibiotic therapy, but readmissions were more frequent. Long-term risks included recurrence. However, laparoscopic appendectomy has reduced complications compared to open surgery. While no definitive answer was provided, the meta-analysis offers data for informed discussions between healthcare providers and patients.

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