Pessary or Progesterone for Preterm Birth? Advantage Med

A study comparing cervical pessary and vaginal progesterone for preventing preterm birth in women with a short cervix found no significant difference in perinatal complications. Among women with a cervical length of ≤ 25 mm, pessaries appeared less effective at preventing spontaneous preterm birth and adverse outcomes. The open-label, randomized controlled trial included 635 women with healthy singleton pregnancies. Adverse perinatal outcomes were 6% in both groups, with a higher rate of spontaneous preterm birth in the pessary group for those with a cervical length of ≤ 25 mm. The study suggests that for this subgroup, a cervical pessary should not be used as preventive treatment.

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