Pan-cancer analysis uncovers a new class of promising CAR T–cell immunotherapy targets

Artistic rendering of a chimeric antigen receptor (CAR) (blue) on a T cell attaching to a targeted cancer protein (red) on another cell. Credit: St. Jude Children’s Research Hospital Targeting anti-cancer therapy to affect cancer cells but not healthy cells is challenging. For chimeric antigen receptor (CAR) T–cell immunotherapy, where a patient’s own immune cells…

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Study shows extending interval between colonoscopies feasible after negative result

For individuals without a family history of colorectal cancer (CRC), increasing the interval between colonoscopies for those with a first colonoscopy with negative findings seems safe and can avoid unnecessary colonoscopies, according to a study published online May 2 in JAMA Oncology. Qunfeng Liang, from the German Cancer Research Center in Heidelberg, and colleagues assessed…

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How music affects the cognitive health of older adults

Credit: Andrea Piacquadio on Pexels Listening to music benefits older adults’ cognitive health, even if it’s music they haven’t heard before or don’t enjoy very much, according to a study by Simon Fraser University and Health Research BC researchers. Led by SFU neuroscientist Sarah Faber, the study published in Network Neuroscience discovered that listening to…

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Analysis shows gender and racial disparities in pulmonary embolism treatment

New data from the REAL-PE analysis investigated catheter-based pulmonary embolism (PE) treatment, showing women and Black people were less frequently treated with minimally invasive therapy compared to men or non-Black patients. The late-breaking results were presented today at the Society for Cardiovascular Angiography & Interventions (SCAI) 2024 Scientific Sessions. PE is often caused by blood…

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MHFA training for correctional officers may boost mental health support in prisons

According to Rutgers Health researchers, training correctional officers in Mental Health First Aid (MHFA) for adults, a 7.5-hour national education program from the National Council of Mental Wellbeing, may help provide them with the necessary skills to effectively identify signs and symptoms of mental distress and advocate for incarcerated individuals facing mental health crises. Led…

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Study shows high rates of hip osteoarthritis among older adults with spinal deformity

Credit: Unsplash/CC0 Public Domain One-third of patients undergoing surgery for adult spinal deformity (ASD) also have severe osteoarthritis (OA) of the hip—which is associated with worse spinal alignment and physical functioning, reports a study in the Journal of Bone & Joint Surgery. These differences persist even following operative treatment of ASD, according to the new…

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Novel vaccine approach targets AML and other blood cancers

Acute myeloid leukemia (AML) is a type of blood cancer that forms in the soft marrow of the bones, typically attacking cells that would otherwise form the key component of the body’s immunodefense system, white blood cells. In a new study published in Blood Advances, researchers from the UChicago Pritzker School of Molecular Engineering’s Hubbell Lab created with a…

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