Inflammatory disease not major risk factors for severe COVID-19, focus on comorbidities urged

In a recent study published in The Lancet Digital Health, a group of researchers analyzed severe coronavirus disease 2019 (COVID-19) outcomes in patients with immune-mediated inflammatory diseases (IMIDs), focusing on the effects of medications, comorbidities, and vaccination status during different pandemic phases. Study: Machine learning to understand risks for severe COVID-19 outcomes: a retrospective cohort study…

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Jump-Start Your Exercise With This Mindset Reset

May 3, 2024 – There are plenty of reasons to exercise, but some are more motivating than others.  Perhaps the sexiest motivator – and the one people tend to go with, especially with warm weather around the corner – is to build the “beach body.”  The problem: Setting big expectations for weight loss can position…

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MicroRNAs Predict Pancreatic Cancer Risk Years in Advance

TOPLINE: Researchers have identified specific circulating microRNAs (miRNAs) in blood samples that can identify individuals at high risk of developing pancreatic cancer within 5 years, potentially improving early detection and outcomes. METHODOLOGY: Early detection of pancreatic cancer could improve patient prognosis, but clinically viable biomarkers are lacking. In a two-stage study, researchers screened and validated…

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Profluent releases AI-enabled OpenCRISPR-1 to edit the human genome

AI-enabled protein design company Profluent has leveraged artificial intelligence to design an open-source gene editor called OpenCRISPR-1, demonstrating the technology can be used to create molecules with the power to edit human DNA. Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology, developed more than a decade ago, allows scientists to modify DNA sequences within living…

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How cancer cells harness energy to drive disease progression

The Warburg effect and metabolic rewiring. Credit: Cancer Biology & Medicine Researchers have revealed crucial insights into how the Warburg effect causes the dedifferentiation of cancer cells through epigenetic reprogramming. This discovery potentially opens up new avenues for cancer treatments that target cellular metabolism. A century after Otto Warburg first described the phenomenon where cancer…

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Amgen, Illumina, Novo Nordisk, and more

Want to stay on top of the science and politics driving biotech today? Sign up to get our biotech newsletter in your inbox. Good morning! A crowdsourced Readout today, to be sure, with contributions from STAT’s Jason Mast, Elaine Chen, and Jonathan Wosen. We get into earnings from Novo Nordisk, Amgen, and Illumina, and see…

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Chronic Spontaneous Urticaria: What to Know

Chronic spontaneous urticaria (CSU) can make you feel itchy and uncomfortable. It causes hives that come and go unexpectedly. You probably wonder why you get them and what to do about them.There’s no clear cause of chronic spontaneous urticaria, or chronic hives, but you and your doctor can manage it.“When I diagnose a patient with…

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