Trials of Psychological Interventions for Depression Rarely Assess Suicidality

A systematic review and meta-analysis published in The Lancet Psychiatry found that clinical trials of psychological interventions for depression often do not assess suicidality, despite the known association between depression and suicide risk. Most trials did not include assessments for suicide, with only a small number reporting on suicidal thoughts and behaviors as adverse events….

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Attack of the Medicare Machines

In this episode of “An Arm and a Leg,” host Dan Weissmann explores the dark side of the American health care system, focusing on Medicare Advantage plans using an algorithm owned by UnitedHealth Group to make decisions about patient care. This algorithm has caused people to be prematurely discharged from nursing homes, leading to adverse…

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Medical cannabis use decreased in states where recreational use is legalized, study shows

Enrollment in medical cannabis programs increased by 33% from 2020 to 2022, but decreased in states where nonmedical adult use was legalized. The prevalence of medical cannabis use among U.S. citizens has increased significantly in the past decade. A study found that patient enrollment dropped dramatically in some states following the legalization of nonmedical adult-use…

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Vertex to buy Alpine Immune Sciences for $4.9 billion

Vertex Pharmaceuticals is acquiring Alpine Immune Sciences for $4.9 billion, marking its largest acquisition to date. The deal includes a promising drug called povetacicept, which is designed to treat IgA nephropathy (IgAN), a kidney autoimmune disorder affecting 130,000 people in the U.S. The drug will enter Phase 3 clinical development later this year. This acquisition…

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Research highlights STON2 variations involved in synaptic dysfunction and schizophrenia-like behaviors

The study focused on STON2 variations related to synaptic dysfunction and schizophrenia-like behaviors. The C-C (307Pro-851Ala) haplotype of STON2 was found to increase susceptibility to schizophrenia in the Chinese Han population. This variation leads to deficits in synaptic transmission, short-term plasticity, and schizophrenia-like behaviors in mice. Pharmacogenomic data showed that patients with this haplotype responded…

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Systematic reviews find inadequate evidence on the use of puberty blockers and hormones for gender distress

Two systematic reviews found that evidence on the use of puberty blockers and hormones for children and young people with gender-related distress is inadequate, leading to uncertainty about their effectiveness and impact on health. The studies showed limited quality and inconsistent evidence on key outcomes. Clinical guidelines are often not evidence-based, and the need for…

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