New “GPS nanoparticle” delivers a genetic punch to the protein implicated in tumor spread

Researchers developed a “GPS nanoparticle” that targets cancer cells to deliver a genetic punch, potentially treating basal-like breast cancers more effectively. This technology, published in ACS Nano, uses a Trojan horse nanoparticle disguised with special lipids carrying CRISPR-Cas9 molecules to target and knock down cancer-causing genes. The nanoparticles are designed to respond in the low…

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No Net HF Benefit for Interarterial Shunt Device

An interarterial shunt (IAS) device that showed promise in improving heart failure (HF) in pilot studies did not meet the primary efficacy endpoint in a pivotal trial. The trial showed potential harm among patients with preserved left ventricular ejection fraction (LVEF) greater than 40%. Results indicated that the IAS device was beneficial for patients with…

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Journal Club: WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome

ME/CFS is a syndrome that affects millions of people worldwide, causing crushing fatigue, muscle aches, and difficulty sleeping, among other symptoms. While the cause of this illness has been a mystery, recent research has discovered a potential link between ME/CFS and a protein called WASF3. The study found that some ME/CFS patients have higher levels…

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What You Can Do About It

The article discusses the issue of hearing loss and offers solutions for managing it. It emphasizes the importance of seeking medical help and exploring treatment options, such as hearing aids and implants. The article also highlights the significance of making lifestyle changes to protect one’s hearing, including reducing exposure to loud noises and using ear…

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