The molecular interplay between axon degeneration and regeneration.
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The molecular interplay between axon degeneration and regeneration.
Dev Neurobiol. 2018 Jul 18;:
Authors: Girouard MP, Bueno M, Julian V, Drake S, Byrne AB, Fournier AE
Abstract
Neurons face a series of morphological and molecular changes following trauma and in the progression of neurodegenerative disease. In neurons capable of mounting a spontaneous regenerative response, including invertebrate neurons and mammalian neurons of the peripheral nervous system (PNS), axons regenerate from the proximal side of the injury and degenerate on the distal side. Studies of Wallerian degeneration slow (WldS /Ola) mice have revealed that a level of coordination between the processes of axon regeneration and degeneration occurs during successful repair. Here, we explore how shared cellular and molecular pathways that regulate both axon regeneration and degeneration coordinate the two distinct outcomes in the proximal and distal axon segments. © 2018 Wiley Periodicals, Inc. Develop Neurobiol, 2018.
PMID: 30022605 [PubMed – as supplied by publisher]