National Library of Medicine

Lab Anim. 2021 Apr 15:236772211000370. doi: 10.1177/00236772211000370. Online ahead of print.ABSTRACTThe liver receives dual blood supply from the hepatic artery and portal vein. The pig is often used as an animal model in positron…

Transl Clin Pharmacol. 2021 Mar;29(1):65-72. doi: 10.12793/tcp.2021.29.e6. Epub 2021 Mar 23.ABSTRACTHistamine acts by binding to four histamine receptors (H1 to H4), of which the H1 is known to participate in dilate blood vessels,…

Transl Clin Pharmacol. 2021 Mar;29(1):53-64. doi: 10.12793/tcp.2021.29.e5. Epub 2021 Mar 22.ABSTRACTFor the treatment of hypertension, fixed-dose combinations (FDCs) of antihypertensive drugs can provide complementary benefits from…

Crit Rev Toxicol. 2021 Apr 15:1-24. doi: 10.1080/10408444.2020.1860903. Online ahead of print.ABSTRACTAre dose-response relationships for benzene and health effects such as myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML)…

Biomedicine (Taipei). 2020 Sep 1;10(3):33-40. doi: 10.37796/2211-8039.1039. eCollection 2020.ABSTRACTBACKGROUND: Radiculopathy due to lumbar or cervical disc disease is the most common chronic neuropathic pain in adults. The aim of…

Transl Clin Pharmacol. 2021 Mar;29(1):33-44. doi: 10.12793/tcp.2021.29.e3. Epub 2021 Mar 10.ABSTRACTClozapine has been used as a treatment of schizophrenia. Despite its large interindividual variability, few reports addressed the…

Int J Nanomedicine. 2021 Apr 7;16:2667-2687. doi: 10.2147/IJN.S306831. eCollection 2021.ABSTRACTPURPOSE: The goal was to directly deliver curcumin, a natural polyphenolic anticancer and anti-inflammatory compound, to the lung tissues…

Ther Adv Infect Dis. 2021 Mar 30;8:20499361211005965. doi: 10.1177/20499361211005965. eCollection 2021 Jan-Dec.ABSTRACTBACKGROUND: While vancomycin loading doses may facilitate earlier pharmacokinetic-pharmacodynamic target attainment,…

Clin Ophthalmol. 2021 Apr 7;15:1433-1442. doi: 10.2147/OPTH.S216912. eCollection 2021.ABSTRACTLong-acting, slow-release injectable fluocinolone intravitreal implants have been approved for the treatment of non-infectious uveitis…

ACS Chem Neurosci. 2021 Apr 14. doi: 10.1021/acschemneuro.1c00184. Online ahead of print.ABSTRACTSince 2002, no clinical candidate against Alzheimer's disease has reached the market; hence, an effective therapy is urgently needed. We…

J Med Chem. 2021 Apr 14. doi: 10.1021/acs.jmedchem.1c00263. Online ahead of print.ABSTRACTIn this study, we report the design and synthesis of a series of novel thiophene-arylamide compounds derived from the noncovalent…

Expert Rev Clin Pharmacol. 2021 Apr 14. doi: 10.1080/17512433.2021.1917377. Online ahead of print.ABSTRACTINTRODUCTION: Oxcarbazepine is commonly used as first-line treatment for partial and generalized tonic-clonic seizures. Owing to…

Int J Hematol. 2021 Apr 13. doi: 10.1007/s12185-021-03144-4. Online ahead of print.ABSTRACTBosutinib is approved in the United States, Europe, Japan, and other countries for treatment of newly diagnosed chronic phase (CP) chronic myeloid…

AAPS PharmSciTech. 2021 Apr 13;22(3):132. doi: 10.1208/s12249-021-01992-1.ABSTRACTThe main objective of this study was to develop an in vivo predictive dissolution (IVPD) model for topiroxostat immediate-release (IR) formulation by the…

Anal Bioanal Chem. 2021 Apr 14. doi: 10.1007/s00216-021-03307-6. Online ahead of print.ABSTRACTClavulanic acid is a molecule with antimicrobial effect used in several livestock species treatment. Its inclusion in the treatment of…

AACE Clin Case Rep. 2020 Dec 28;7(1):20-22. doi: 10.1016/j.aace.2020.11.014. eCollection 2021 Jan-Feb.ABSTRACTOBJECTIVE: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a novel group of oral hypoglycemic agents with multiple proven…

Ment Health Clin. 2021 Mar 31;11(2):70-74. doi: 10.9740/mhc.2021.03.070. eCollection 2021 Mar.ABSTRACTThe interaction between methadone and central nervous system depressants can cause serious adverse effects, including profound…

Ann Transl Med. 2021 Mar;9(6):504. doi: 10.21037/atm-21-981.ABSTRACTBACKGROUND: Acute myocardial infarction (MI) is the primary factor leading to cardiovascular diseases, which are the main causes of morbidity and mortality in developed…

Mol Cancer Ther. 2021 Apr 13:molcanther.0717.2020. doi: 10.1158/1535-7163.MCT-20-0717. Online ahead of print.ABSTRACTMutations in the neurofibromatosis type 2 (NF2) gene that limit or abrogate expression of functional Merlin are common…

Expert Rev Clin Pharmacol. 2021 Apr 14. doi: 10.1080/17512433.2021.1917375. Online ahead of print.ABSTRACTINTRODUCTION: Increasing resistance of gram-negative bacteria poses a serious threat to global health. Thus, efficacious and safe…