inhibition

Mitochondria are the power plants of the cell, packaging chemical energy store molecules through the activities of electron transport chain protein complexes. Some forms of interference in the operation of these complexes can be…

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Epibolin, a plasma protein, was initially purified on the basis of its ability to enhance spreading of keratinocytes. It is now known that epibolin is identical to serum spreading factor, S protein, and vitronectin, and the current name…

Since the confirmation of cellular senescence as an important contributing cause of aging, a great many research initiatives have focused on the biochemistry of senescent cells, in search of new approaches to rejuvenation therapies. A…

Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice Source link

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The key to a universal cancer therapy is to find a vulnerability that is (a) common to all cancers, something fundamental to cancer as a class, (b) nowhere near as prevalent in normal cells, and (c) can be cost-effectively exploited as…

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Noyce, A; (2020) Tumor Necrosis Factor Inhibition and Parkinson Disease: A Mendelian Randomization Study. Neurology (In press). Source link

The researchers involved in today's research have been investigating the role of prostaglandin E2 (PGE2) in muscle stem cell function for some years. PGE2 levels decline with age, and this appears to be sufficient to cause a sizable…

Advanced-glycation end products (AGEs) cause issues in two major ways. Firstly a few species of persistent AGE can cross-link molecules of the extracellular matrix, changing tissue properties in harmful ways, such as loss of elasticity…

Non-neuronal acetylcholine (Ach) plays important roles in various aspects of cell biology and homeostasis outside the neural system. Keratinocytes has a functional cholinergic mechanism, suggesting that they respond to Ach. However, the…