Antidepressant medication use is not associated with long-term cognitive decline, brain atrophy, or dementia risk, according to results from a prospective cohort study published in Alzheimer’s and Dementia. Although antidepressants are used widely and have become more frequently used among older adults, the long-term effects of antidepressant use on cognition and dementia remain uncertain. To…
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Non-enzymatic production of diindoles. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-46559-3 Researchers at the University of Toronto have found naturally occurring compounds in the gut that can be harnessed to reduce inflammation and other symptoms of digestive issues. This can be achieved by binding the compounds to an important, but poorly understood, nuclear receptor. The gut…
TOPLINE: iGlarLixi, a fixed-ratio combination of insulin glargine and the glucagon-like peptide-1 receptor agonist (GLP-1 RA) lixisenatide, improves glycemic control, with a low rate of hypoglycemia, in adults with inadequately controlled type 2 diabetes (T2D). METHODOLOGY: The 2022 Consensus Statement from the American Diabetes Association/European Association for the Study of Diabetes suggests that a fixed-ratio…
Hospitals’ operating margins and patient volumes dropped slightly in March, according to a new report from Kaufman Hall. Hospitals’ single-month operating margin index closed out March at 3.4% — a small dip from February’s 3.6%. It’s also worth noting that March ended with a year-to-date operating margin index of 3.9% — which is still significantly…
Therapist burnout negatively affected the delivery of trauma-focused psychotherapies (TFPs) to patients with posttraumatic stress disorder (PTSD), according to study results published in JAMA Network Open. Clinicians who experience burnout have previously reported that their symptoms affect the quality of care they deliver, their communication with patients, and the likelihood of making a medical error….
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Vivien Dugan isn’t getting much sleep these days. The director of the influenza division at the Centers for Disease Control and Prevention, Dugan is leading the team of CDC scientists that is working with partners — in the U.S. Department of Agriculture, the Food and Drug Administration, and state and local health departments — to respond…
Credit: Pixabay/CC0 Public Domain Neuroblastoma is a common pediatric cancer that originates in developing nerve cells outside the brain. While increasingly intensive treatments have improved the survival of patients with high-risk neuroblastoma, currently more than 40% of patients do not survive. New research from the University of Chicago shows the potential for a promising new…
Expanding eligibility criteria is a strategy for improving the inclusion of traditionally underrepresented populations in clinical trials, according to a study. The results were published in NEJM Evidence by Maneet Kaur, PhD, epidemiologist and senior scientist at Flatiron Health, New York, and colleagues. Flatiron Health is an independent member company of the Roche group and…
