Surgical resection of ripple onset predicts outcome in pediatric epilepsy.
Ann Neurol. 2018 Jul 18;:
Authors: Tamilia E, Park EH, Percivati S, Bolton J, Taffoni F, Peters JM, Grant PE, Pearl PL, Madsen JR, Papadelis C
OBJECTIVE: In patients with medically refractory epilepsy (MRE), interictal ripples (80-250 Hz) are seen in large brain areas whose resection may be unnecessary for seizure-freedom. This limits their utility as epilepsy biomarkers for surgery. We assessed the spatiotemporal propagation of interictal ripples on intracranial electroencephalography (iEEG) in children with MRE, compared it with the propagation of spikes, identified ripples that initiated propagation (onset-ripples), and evaluated their clinical value as epilepsy biomarkers.
METHODS: Twenty-seven children who underwent epilepsy surgery were studied. We identified propagation sequences of ripples and spikes across multiple iEEG contacts and calculated each ripple or spike latency from the propagation onset. We classified ripples and spikes into categories (i.e. onset, spread, and isolated) based on their spatiotemporal characteristics, and correlated their mean rate inside and outside resection with outcome (good-outcome: Engel 1 vs. poor-outcome: Engel≥2). We determined as onset-zone, spread-zone and isolated-zone, the areas generating the corresponding ripple or spike category, and evaluated the predictive value of their resection.
RESULTS: We observed ripple propagation in all patients and spike propagation in 25 patients. The mean rate of onset-ripples inside resection predicted the outcome (odds-ratio=5.37, p=0.02) and correlated with Engel class (rho=-0.55, p=0.003). Resection of the onset-ripple-zone was associated with good-outcome (p=0.047). No association was found for the spread-ripple-zone, isolated-ripple-zone, or any spike-zone.
INTERPRETATION: Interictal ripples propagate across iEEG contacts in children with MRE. The association between the onset-ripple-zone resection and good-outcome indicates that onset-ripples are promising epilepsy biomarkers, which estimate the epileptogenic tissue better than spread-ripples or onset-spikes. This article is protected by copyright. All rights reserved.
PMID: 30022519 [PubMed – as supplied by publisher]