Safety evaluation of simultaneous resection of colorectal primary tumor and liver metastasis after neoadjuvant therapy: A propensity score matching analysis.
Am J Surg. 2018 Sep 21;:
Authors: Wu Y, Liu F, Song W, Liang F, Wang L, Xu Y
BACKGROUND: Considering the surgical safety and perioperative complications, simultaneous resection after neoadjuvant therapy is not commonly recommended.
METHODS: A total of 253 patients were included in study. Comparison of the short-term outcomes was performed after propensity score adjustment in Group A (n = 96) and Group B (neoadjuvant therapy, n = 96).
RESULTS: There was no postoperative mortality. After matching, the differences from surgical confounders were well-balanced. Morbidity (15.6% vs. 15.6%, p = 0.981), and Clavien-Dindo grade of complications (p = 0.710) were similar. No difference was found when the complications were divided according to the origin (general, colorectal and hepatic). Length of the hospital stays also did not differ between the groups (p = 0.482). More importantly, there was no increase in the number of patients with delayed adjuvant treatment after surgery in Group B.
CONCLUSIONS: Neoadjuvant treatment did not increase morbidity, length of hospital stays and influence adjuvant treatment after simultaneous resection.
PMID: 30268420 [PubMed – as supplied by publisher]