medresearch: Research Paves Way for Novel Therapy to Treat…


Research Paves Way
for Novel Therapy to Treat Osteoporosis, Atherosclerosis

Researchers at the University of Arkansas for Medical
(UAMS) and University of California San Diego, using a mouse model,
have shown that a type of blood protein, or antibodies, that everyone has
protects against osteoporosis and atherosclerosis. The researchers found that these
antibodies protect against bone loss, as well as cardiovascular disease induced
by a high-fat diet.

“Together, the two studies provide proof of principle for a
new therapy for two very common diseases, osteoporosis and atherosclerosis,
simultaneously,” says Elena Ambrogini, MD, PhD, an assistant professor in the
Division of Endocrinology and Metabolism, part of the Department of Internal
Medicine in the UAMS College of Medicine, and a staff physician at Central
Arkansas Veterans Healthcare System.  “In
the case of osteoporosis, this would be a new anabolic therapy, meaning that it
can build new bone as opposed to only preventing the loss of old bone.”


Funding: Osteoporosis
Center’s National Institutes of Health program project; CAVHS; the Arkansas
Biosciences Institute; the UAMS Translational Research Institute; and the
College of Medicine’s Barton Endowment and Initiative for Bone and Joint

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