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NICE Approves Dual Immunotherapy for Aggressive Bowel Cancer

, 2025-04-23 09:27:00 The National Institute for Health and Care Excellence (NICE) has recommended  nivolumab (Opdivo) plus ipilimumab (Yervoy) for some people in England with advanced colorectal cancer. The treatment is recommended for adults with untreated, unresectable, or metastatic colorectal cancer that shows high microsatellite instability (MSI-H) or mismatch repair deficiency (dMMR). In final draft…

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Mater Private Network hosts leading cardiologists at annual Heart Summit to shape the future of cardiac care

Editorial Staff , 2025-04-23 07:30:00 This year’s programme included expert-led discussions on emerging treatments and innovative technologies Valentín Fuster and Robert Byrne are pictured at the Mater Private Network’s annual Dublin Heart Summit at the Royal College of Surgeons in Ireland (RCSI), which welcomed over 700 cardiologists, GPs and other healthcare professionals to discuss the…

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Specific patient characteristics might contribute to poor recovery after hip replacement surgery

, 2025-04-23 07:10:00 Credit: RDNE Stock project from Pexels Hip replacement surgery, or total hip arthroplasty (THA), can lessen pain and improve function in individuals with hip osteoarthritis, but some patients continue to experience long-term physical deficits—including muscle weakness, decreased functional mobility, and increased fall risk—after the procedure. New research published in the Journal of…

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Raman spectroscopy in bioprocessing: Principles and benefits

, 2025-04-23 07:52:00 In this interview, Dr. Nimesh Khadka, Senior Product Application Specialist at Thermo Fisher Scientific, explores the role of Raman spectroscopy as a process analytical tool (PAT) in bioprocess monitoring, highlighting its molecular specificity, real-time capabilities, and advantages over traditional analytical methods like ultraviolet-visible (UV-Vis) spectroscopy. Could you explain the principles and functioning of Raman…

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AI Shows Promise for Rapid NSTEMI Diagnosis

, 2025-04-23 07:22:00 CHICAGO — A new artificial intelligence (AI) model performed about as well as high-sensitivity troponin for the detection of non–ST-elevated myocardial infarction (NSTEMI) on an ECG, but better than clinicians. “Essentially, the model has rediscovered features on the ECG that we, as clinicians, already recognize as ischemic, but it qualifies these features…

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Roche, NIH funding ban, Galapagos, Wegovy

Elaine Chen , 2025-04-22 13:12:00 Want to stay on top of the science and politics driving biotech today? Sign up to get our biotech newsletter in your inbox. Good morning, today we look at seemingly conflicting messaging coming out of the NIH, the departure of a key executive at  Galapagos, and more. The need-to-know this morning Roche…

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DNA repair mechanism may hold key to overcoming tumor resistance to radiotherapy

, 2025-04-22 20:26:00 Schematic illustration of ZNF451 regulating DNA damage repair mechanism. Credit: Zhao Guoping A research team has unveiled a crucial mechanism that helps regulate DNA damage repair, with important implications for improving cancer treatment outcomes. The result was published in Cell Death & Differentiation. The team was led by Professor Zhao Guoping at…

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Beckman Coulter Life Sciences transforms purification with the launch of the OptiMATE Gradient Maker

, 2025-04-23 03:41:00 Beckman Coulter Life Sciences, a Danaher company and a global leader in laboratory automation and innovation, announces the launch of the OptiMATE Gradient Maker, a groundbreaking instrument designed to automate the process of density gradient ultracentrifugation (DGUC). The new system accelerates purification processes by up to 75% while improving consistency and reproducibility….

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Hepatitis Testing, Guidance, on Hold as Labs Close

, 2025-04-23 05:59:00 The closure of the Centers for Disease Control and Prevention (CDC)’s Division of Viral Hepatitis in the wake of the administration’s restructuring of the Department of Health and Human Services leaves clinicians and public officials with no resources to process specimens and track outbreaks, according to several experts.  The CDC’s website for…

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What Trump’s AI memos mean for health care

Mario Aguilar , 2025-04-22 16:13:00 You’re reading the web edition of STAT’s Health Tech newsletter, our guide to how technology is transforming the life sciences. Sign up to get it delivered in your inbox every Tuesday and Thursday. In new memos released this month, the Trump administration spelled out its approach to artificial intelligence. At first glance,…

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DASH diet and salt reduction work together to reduce cardiovascular risk

, 2025-04-23 04:07:00 New analysis shows that pairing a low-sodium diet with DASH eating habits reduces cardiovascular risk by over 14%, with the biggest wins for women and Black adults facing high blood pressure. Study: Dietary sodium reduction lowers 10-year atherosclerotic cardiovascular disease risk score: Results from the DASH-sodium trial. Image Credit: New Africa / Shutterstock In…

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What Small Clues Can Teach About Lifesaving Diagnoses

, 2025-04-22 11:19:00 A general practitioner (GP) recently reported that, by chance, he came across a life-threatening diagnosis. He had been chatting with a patient, during which the patient casually mentioned his favorite TV show, “Let’s Dance,” a popular dance competition show in Germany. The patient said that he usually used the commercial breaks to…

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Interferon regulatory factor 8 identified as key driver of liver fat buildup in NAFLD

, 2025-04-23 03:04:00 Non-alcoholic fatty liver disease (NAFLD) is a hepatic metabolic syndrome resulting from lipid metabolic imbalance. Interferon regulatory factor 8 (IRF8) is well known for its roles in immune cell differentiation and tumor pathogenesis; however, its role in regulating glucose homeostasis and lipid metabolism remains unclear. This research, published in the Genes &…

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Underfunding Halts Malnutrition Treatments in Ethiopia

, 2025-04-22 11:52:00 GENEVA (Reuters) -The World Food Programme suspended malnutrition treatment for 650,000 malnourished women and children in Ethiopia this week due to severe funding shortages, the U.N. agency said, with millions more at risk of losing access to aid. WFP gets financing from 15-20 donors including the United States but many of them…

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Post-Pandemic Surge of Group A Strep Infections in Children

, 2025-04-22 11:54:00 TOPLINE: Data over a 32-year period showed that the incidence of invasive group A streptococcal (iGAS) infections in children remained stable before 2011, increased until 2020, declined during the pandemic, and subsequently sharply rose in 2023, with a notable surge contributed by respiratory tract infections. METHODOLOGY:  Researchers evaluated the incidence and clinical…

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Women’s Health Initiative, known for hormone trials, to lose U.S. funds

Elizabeth Cooney , 2025-04-22 21:24:00 Elizabeth Cooney is a cardiovascular disease reporter at STAT, covering heart, stroke, and metabolic conditions. Federal funding for the Women’s Health Initiative, which as one of the largest research projects in women’s health has shaped treatment of menopause, osteoporosis, and nutrition, will stop in September, the program said Tuesday in…

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Federal COVID websites now promote lab leak theory

, 2025-04-22 23:50:00 by I. Edwards The Trump administration has replaced two major federal websites for COVID information with a new page that promotes the theory that the virus came from a lab in China. COVID.gov and COVIDtests.gov, which once helped people order COVID tests and find public health information, now redirect to a new…

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Both Lifestyle and Mortality Poor in ADHD Patients Post MI

, 2025-04-22 12:00:00 TOPLINE: Adults with myocardial infarction (MI) and attention-deficit/hyperactivity disorder (ADHD) were more likely to smoke, use snus, and have histories of bleeding and chronic obstructive pulmonary disorder (COPD) than those without ADHD. Although ADHD was associated with a higher rate of all-cause mortality, these patients were less likely to participate in follow-up…

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Safer opioid supply improves health outcomes among people at high risk of overdose

, 2025-04-22 22:30:00 Credit: Etatics Inc. from Pexels Research from ICES and Unity Health Toronto shows that safer opioid supply programs and methadone both reduce opioid overdoses, health care utilization, and costs. The work appears in The Lancet Public Health. Safer opioid supply (SOS) programs provide pharmaceutical-grade opioids such as hydromorphone to people struggling with…

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AGA announces $2.4 million in research funding for 74 recipients

, 2025-04-22 19:02:00 The American Gastroenterological Association (AGA) is proud to announce the selection of 74 recipients to receive $2.4 million in research funding through the annual AGA Research Foundation Awards Program. AGA also announces today the addition of 10 pilot grants, totaling $400,000 in funding, to the 2026 awards portfolio to ensure that scientific discovery…

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Severity Increases Hospital Mortality in Hyponatraemia

, 2025-04-22 12:00:00 TOPLINE: Patients with hyponatraemia exhibited higher 30-day mortality rates than those with normal sodium concentrations, and over time, the risk for mortality declined among patients with mild hyponatraemia; however, this trend was less pronounced in those with moderate hyponatraemia and absent in those with severe hyponatraemia. METHODOLOGY: Researchersanalysed the risk for mortality…

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Bristol’s Cobenfy disappoints as supplemental antipsychotic drug

Jason Mast , 2025-04-22 21:36:00 A landmark new treatment for schizophrenia didn’t provide additional benefits to patients when given on top of standard-of-care therapy, Bristol Myers Squibb announced Tuesday. The drug, Cobenfy, was approved last year based on data from three randomized studies comparing the drug to placebo. It was the first new mechanism-of-action approved…

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FDA approved anti-inflammatory drug shows promise for treating alcohol use disorder and pain

, 2025-04-22 19:20:00 A preclinical study from scientists at Scripps Research finds that a drug already FDA-approved for treating inflammatory conditions may help reduce both alcohol intake and pain sensitivity-two issues that commonly co-occur with alcohol use disorder (AUD). The results, published in JCI Insight on April 22, 2025, suggest that the drug apremilast-a phosphodiesterase-4…

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Will These New Drugs Change Your Practice?

, 2025-04-22 12:09:00 A quartet of new medications may improve care of patients with hypertension, urinary tract infections (UTIs), hot flashes, and liver disease, said Gerald W. Smetana, MD, professor of medicine at Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, in a presentation at the American College of Physicians (ACP-IM) Internal Medicine…

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‘I Shudder to Think What Could Have Happened to Me’

, 2025-04-22 20:13:00 Beyoncé‘s mom, Tina Knowles, has opened up about her private battle with breast cancer and shared and urgent message for other women. The author, who recently published her book “Matriarch,” spoke with People about the harrowing time in her life. In the interview, she reveals that she was diagnosed with stage 1…

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Reveleer acquires Novillus to enhance health plan-provider collaboration

, 2025-04-22 17:11:00 California-based healthcare data and analytics company Reveleer has acquired Novillus, which offers a workflow platform for health plans.  Reveleer, formerly Health Data Vision, provides an AI-enabled platform for payers aimed at advancing value-based care. The company offers workflow, data and analytics tools for risk adjustment, quality improvement and member management. It also…

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