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Epigenetic signature helps predict risk of metastatic thyroid cancer progression

, 2025-04-25 16:54:00 Model of differentiated thyroid cancer (DTC) metastatic progression. Credit: Thyroid® (2025). DOI: 10.1089/thy.2024.0303 Researchers from the Endocrine Tumors group at the Germans Trias i Pujol Research Institute (IGTP), in collaboration with five university hospitals, have conducted the first comprehensive study of DNA methylation patterns in metastatic differentiated thyroid cancer (DTC). Published in…

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MD Anderson researchers present promising clinical trial results at AACR 2025

, 2025-04-26 05:06:00 Researchers from The University of Texas MD Anderson Cancer Center will present promising results from clinical trials in three minisymposia abstracts at the American Association for Cancer Research (AACR) Annual Meeting 2025. Findings include a personalized vaccine combination therapy for colorectal cancer, the use of radiotherapy to avoid the toxicities of systemic…

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Topaz Technique Effective for Chronic Plantar Fasciopathy

, 2025-04-25 12:00:00 TOPLINE: Radiofrequency microtenotomy using the Topaz technique led to significant pain reduction, functional improvement, and low complication rates in patients with chronic plantar fasciopathy who were unresponsive to conservative treatments. METHODOLOGY: Researchers conducted a systematic review and meta-analysis of 15 studies involving 1576 patients (mean age, 45-55 years) with chronic plantar fasciopathy…

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Radioiodine therapy found to improve relative survival rates of differentiated thyroid cancer patients

, 2025-04-25 16:57:00 Credit: AI-generated image Differentiated thyroid cancer patients who receive radioiodine (RAI) treatment after surgery have increased relative survival rates compared to those who do not receive the treatment. According to new research published in the April issue of The Journal of Nuclear Medicine, the clear trend for a higher long-term survival rate…

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New Medicare changes ease cost burden for cancer drugs

, 2025-04-26 03:24:00 Even for patients covered by Medicare, annual out-of-pocket costs for lifesaving cancer treatments taken in pill form have often exceeded $10,000-until recently. Thanks to changes in Medicare Part D introduced by the Inflation Reduction Act (IRA) that took effect in 2025, annual out-of-pocket drug costs for all beneficiaries are now capped at…

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Noninvasive Spleen Test Predicts Liver Disease Complications

, 2025-04-25 12:26:00 TOPLINE: Spleen stiffness measurement (SSM) demonstrated strong predictive accuracy for liver decompensation in patients with compensated advanced chronic liver disease (cACLD), with an optimal cutoff of 50 kPa. METHODOLOGY:  Portal hypertension is a key prognostic factor in cACLD. Although hepatic venous pressure gradient measurement is the gold standard for assessing it, noninvasive…

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Akeso wins China approval for cancer drug ivonescimab

Jonathan Wosen , 2025-04-25 15:36:00 Akeso, a Chinese biotech that made headlines for beating Merck’s Keytruda in a head-to-head trial, won approval in China this week for the therapy, a company spokesperson confirmed to STAT. New data show early hints of the medicine improving patient survival — the gold standard outcome of any cancer study….

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Novavax COVID vaccine moves closer to full FDA approval

, 2025-04-25 16:58:00 by I. Edwards Novavax’s COVID-19 vaccine could soon receive full approval from the U.S. Food and Drug Administration (FDA), the company said Wednesday. The update sent Novavax’s stock up more than 21% in early trading. It also helped ease fears that the decision had been delayed by the Trump Administration, The Associated…

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Pharmacists Call Off Collective Action After Funding Deal

, 2025-04-25 12:44:00 The National Pharmacy Association (NPA) has stepped back from plans for coordinated action that could have led to high street pharmacies in England limiting their opening hours and cutting services in a dispute over funding.  The decision follows a settlement offer from the government, which the NPA described as a “clear step…

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VIDEO: Nordic, Harrow launch generic Maxitrol

Philip Gioia; Nancy Hemphill, ELS, FAAO , 2025-04-26 01:15:00 LOS ANGELES — Nordic Pharma and Harrow partnered to launch an authorized generic of Maxitrol, Nordic President Philip Gioia said in this Healio Video Perspective from SightLine.Gioia said the neomycin and polymyxin B sulfates and dexamethasone ophthalmic suspension will offer a more cost-effective generic option for…

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US Preventive Services Task Force recommends counseling to prevent perinatal depression

, 2025-04-25 17:00:00 The U.S. Preventive Services Task Force (USPSTF) recommends counseling for women at increased risk for perinatal depression (PND). This recommendation forms the basis of a draft recommendation statement published online April 22. Researchers from the USPSTF reviewed the benefits and harms of primary care-relevant interventions to prevent PND to update the 2019…

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Rare lung cell found to protect against COVID-19 death

, 2025-04-25 18:46:00 A rare cell type in the lungs is essential to survival from the COVID-19 virus, a new study shows. Experiments in mice infected with the SARS-CoV-2 virus revealed that the immune cell class in question, called nerve and airway-associated interstitial macrophages, or NAMs, may keep the human immune system’s initial counterattack on…

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Childhood Antibiotic Use Linked to Increased Health Risks

, 2025-04-25 12:54:00 TOPLINE: Children who received multiple antibiotic courses between birth and 2 years of age had a higher risk of developing asthma, food allergies, allergic rhinitis, and intellectual disability, according to a new study.  METHODOLOGY: Researchers analyzed data from a large nationally representative population to examine the associations between antibiotic exposure patterns within…

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Researchers pioneer method to measure liver tissue stiffness without damage

, 2025-04-25 18:59:00 Researchers in South Korea have developed an organoid disease model and non-destructive stiffness analysis technology for evaluating the efficacy of new drugs for fatty liver disease. The research team led by Dr. Hyunwoo Kim and Dr. Myungae Bae at the Korea Research Institute of Chemical Technology (KRICT) has developed the nano-probe-based quantitative stiffness…

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NICE Recommends Ribociclib for High-Risk Early Breast Cancer

, 2025-04-25 13:25:00 The National Institute for Health and Care Excellence (NICE) has recommended ribociclib (Kisqali, Novartis) as an adjuvant treatment for early breast cancer in patients at high risk of recurrence.  The recommendation applies to patients in England with HR-positive, HER2-negative early breast cancer. This is the most common breast cancer subtype, accounting for…

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5 Major Trends Emerging in Healthcare Benefits in 2025

Luidgi Faubert , 2025-04-25 14:12:00 Health insurance is rapidly evolving, requiring providers and employers to be adaptable. If you have employees, you must consider what they need from their coverage while considering costs. Here’s a guide on 2025 developments in health care benefits.  What Are the Major Trends Emerging in Health Care Benefits? Understanding recent…

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Researchers discover brain pathway to ease nicotine withdrawal

, 2025-04-25 19:11:00 According to the World Health Organization (WHO), over 22% of the global population smokes, with more than 9 million smoking-related deaths reported annually. Effective treatments to alleviate nicotine withdrawal symptoms caused by smoking cessation are essential for successful smoking cessation. Currently, approved treatments for nicotine withdrawal include Bupropion and Varenicline, but there…

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FDA Approves Penpulimab for Nasopharyngeal Cancer

, 2025-04-25 14:56:00 The US Food and Drug Administration (FDA) has approved penpulimab-kcqx (Akeso Biopharma) in combination with cisplatin or carboplatin and gemcitabine as first-line treatment for adults with certain types of nasopharyngeal carcinoma (NPC), and as a single agent for certain patients with NPC disease progression on or after other treatments. Specifically, the novel…

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New technology to speed up testing of patient tissue samples

Michael McHale , 2025-04-25 07:30:00 Development means that Tallaght laboratory ‘future-proofed’ for expected increases in demand The installation of cutting-edge sample testing technology is set to significantly increase a Dublin hospital’s capacity to test patient samples. The Cellular Pathology Laboratory at Tallaght University Hospital (TUH) recently introduced the Axlab AS-410 M, auto slide preparation system….

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Eli Lilly sues four telehealth companies for selling copycat drugs

, 2025-04-25 17:29:00 Indianapolis-based pharmaceutical behemoth Eli Lilly has filed lawsuits against four compounders claiming that they sold unapproved products that contain tirzepatide, a key ingredient in the company’s weight-loss and diabetes drugs, including top-seller Mounjaro. The lawsuits against Mochi Health, Fella Health and Delilah, and Henry Meds were filed in the U.S. District Court Northern…

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Six NIH institutes get new acting directors

Jonathan Wosen , 2025-04-25 19:29:00 The National Institutes of Health on Friday announced six acting directors to run institutes, many to fill vacancies created by the ouster of predecessors as part of the Trump administration’s unprecedented reshaping of federal scientific agencies. In an email from the NIH Executive Secretariat obtained by STAT, the agency said…

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Key Blood Proteins Predict MASLD Up to 16 Years in Advance

, 2025-04-25 15:30:00 The presence of five key proteins in the blood was strongly associated with the development of metabolic dysfunction-associated steatotic liver disease (MASLD) as much as 16 years before symptoms appeared, new research showed. “This represents the first high-performance, ultra-early (16 years) predictive model for MASLD,” said first author Shiyi Yu, MD, resident…

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Orchestra BioMed’s Hypertension Device Wins FDA Breakthrough Designation

Katie Adams , 2025-04-25 18:06:00 Orchestra BioMed’s hypertension treatment is the latest medical device to earn the FDA’s breakthrough designation. The device is an atrio-ventricular interval modulation therapy, meaning it uses a pacing algorithm to actively lower blood pressure. By granting Orchestra’s product a breakthrough device status, the FDA is putting it on a fast…

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HeartBeam, AccurKardia partner to speed up cardiac diagnosis

, 2025-04-25 17:51:00 ECG diagnostics software platform AccurKardia and cardiac medical technology company HeartBeam are joining forces to make AccurKardia’s ECG analysis software available on HeartBeam’s devices.  HeartBeam’s cable-free, 12-lead ECG system captures electrical signals from the heart from three directions to assess arrhythmias.  The platform is designed for portable devices so physicians can identify…

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What to know about processed and ultra-processed food

, 2025-04-25 17:04:00 Amy Fletcher, Pilot Plant manager, and Reid Waterman, third-year food science major, start the ice cream maker in the pilot food processing facility on the UC Davis campus. Store-bought ice cream usually falls into the “ultra-processed” food category. Credit: Alysha Beck/UC Davis Take a stroll down the middle aisles of any American…

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Traditional African diet can protect against chronic diseases in just two weeks

, 2025-04-25 17:26:00   A traditional African diet rich in vegetables, fibre, and fermented foods can reverse inflammation and protect against chronic diseases in just two weeks, while Western diets exacerbate these conditions, researchers say. The research, conducted by scientists from Radboud University Medical Centre, in the Netherlands, and KCMC University, in Tanzania, found that even a short-term…

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Popular Diabetes Drugs Linked to Fall Risk in T2D

, 2025-04-25 16:06:00 TOPLINE:  In patients with type 2 diabetes (T2D), sodium-glucose cotransporter 2 (SGLT2) inhibitors significantly increase the risk for falls, and combined use with glucagon-like peptide 1 receptor agonists (GLP-1 RAs) further heightened this risk, emphasizing the need for careful management and support for patients receiving these therapies. METHODOLOGY: The increased risk for…

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Why a Platform Approach Outperforms Point Solutions with Pritesh Patel, COO of Andor Health

, 2025-04-25 15:03:00 As artificial intelligence (AI) continues to reshape industries, healthcare remains pivotal. While many health systems have attempted to implement AI through point solutions—single-use applications that address specific needs—these fragmented tools often fail to deliver lasting value. The real potential of AI lies in a platform approach, where a unified system can repurpose…

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Hard Work, Soft Beds, and No Doctors

Terence Cosgrave , 2025-04-25 07:30:00 The doctors gathered in Killarney for the IMO AGM do not lack passion, writes Terence Cosgrave Once again this weekend, in Killarney — hometown of George McNeice, where the air smells of rain and redemption, the doctors of Ireland gather. The annual assembly of the Irish Medical Organisation (IMO), an…

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