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RFK Jr. urged to restore public comment on HHS business

Isabella Cueto , 2025-05-01 17:00:00 Isabella Cueto covers the leading causes of death and disability: chronic diseases. Her focus includes autoimmune conditions and diseases of the lungs, kidneys, liver (and more). She writes about intriguing research, the promises and pitfalls of treatment, and what can be done about the burden of disease. You can reach…

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Study uses artificial intelligence to classify patient pain archetypes after knee replacement

, 2025-05-02 06:03:00 A study using artificial intelligence to classify patient pain archetypes and identify risk for severe pain after knee replacement has earned a Best of Meeting award at the 50th Annual Meeting of the American Society of Regional Anesthesia and Pain Medicine (ASRA). The honor, which recognizes excellence in scientific research, is awarded to…

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Sepsis-Linked Kidney Injury in ICUs Is Common and Lethal

, 2025-05-02 06:30:00 TOPLINE: A retrospective analysis using the updated definition of sepsis-associated acute kidney injury (SA-AKI) reported this condition affects nearly half of patients admitted to the intensive care unit (ICU) with sepsis, with 25% dying during their hospital stay. METHODOLOGY: Sepsis and AKI are complex heterogeneous syndromes. In 2023, the definition of SA-AKI…

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FDA to rehire fired staffers who booked safety inspection trips

Associated Press , 2025-05-01 17:29:00 WASHINGTON — For the second time in recent months, the Food and Drug Administration is bringing back some recently fired employees, including staffers who handle travel bookings for safety inspectors. More than 20 of the agency’s roughly 60 travel staff will be reinstated, according to two FDA staffers notified of the plan this…

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Making AI models more trustworthy for high-stakes contexts, like classifying diseases in medical images

, 2025-05-01 20:27:00 We illustrate the addition of test-time augmentation to conformal calibration in green (left) and provide a snapshot of the improvements it can confer (right). We show results on Imagenet, with a desired coverage of 95%, for the 20 classes with the largest predicted set sizes on average (computed over 10 calibration/test splits)….

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New drug technique targets gut inflammation with precision

, 2025-05-02 05:41:00 A new approach to drug design can deliver medicine directly to the gut in mice at significantly lower doses than current inflammatory bowel disease treatments. The proof-of-concept study, published today in Science, introduced a mechanism called ‘GlycoCaging’ that releases medicine exclusively to the lower gut at doses up to 10 times lower…

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Lower Risk for Type 2 Diabetes in Teens Linked to GLP-1s

, 2025-05-02 04:58:00 Youth with obesity but without type 2 diabetes were 31% less likely to develop type 2 diabetes if they were prescribed a glucagon-like peptide 1 (GLP-1) receptor agonist medication instead of an older-generation obesity medication, according to findings presented at the Pediatric Academic Societies (PAS) 2025 Meeting. “This study offers compelling early…

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Bipartisan support for federal research funding, and Dems sharpen arguments against Medicaid work requirements

John Wilkerson , 2025-05-01 18:08:00 You’re reading the web edition of D.C. Diagnosis, STAT’s twice-weekly newsletter about the politics and policy of health and medicine. Sign up here to receive it in your inbox on Tuesdays and Thursdays. I saw the movie Sinners last weekend. That mystical scene where Preacher Boy’s blues guitar summons the past and…

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Medicaid unwinding disrupted kids’ and young adults’ access to chronic disease medicine, study finds

, 2025-05-02 04:10:00 Credit: Unsplash/CC0 Public Domain Children and young adults with depression, schizophrenia, ADHD, asthma and epilepsy can get great relief from medications to control their symptoms, helping them stay in school or work and prepare for their futures. But they should keep taking those medications regularly to get the best results; interruptions can…

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Gut immune cells linked to worsening rheumatoid arthritis

, 2025-05-02 04:12:00 After spending years tracing the origin and migration pattern of an unusual type of immune cell in mice, researchers have shown in a new study how activity of “good” microbes in the gut is linked to rheumatoid arthritis and, potentially, other autoimmune diseases. Scientists first reported in 2016 that specific gut microbes…

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Prostate Cancer Surgeries Drop for Low-Risk Cases

, 2025-05-01 13:29:00 TOPLINE: From 2010 to 2024, the rate of surgeries declined more than fivefold in patients with pathologic grade group 1 (pGG1) prostate cancer, a cohort study found. The small proportion that were performed increasingly involved patients with higher-risk features.  METHODOLOGY: Overtreatment of prostate cancer, particularly in men with low-risk disease, can result…

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Chimeric brain models can help bridge the gap between animal studies and human neurological disorders

, 2025-05-01 20:35:00 Credit: Pixabay/CC0 Public Domain A specialized model used by researchers is becoming a valuable tool for studying human brain development, diseases and potential treatments, according to a team of scientists at Rutgers University-New Brunswick. Known as chimeric brain models, these laboratory tools provide a unique way to understand human brain functions in…

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Secondary Cancer Risk Rises After Cutaneous B-Cell Lymphoma

, 2025-05-01 13:59:00 TOPLINE:  In a large US cohort study, patients with primary cutaneous B-cell lymphoma (pCBCL) had significantly higher risks of developing hematologic and prostate cancers. METHODOLOGY: Researchers analyzed data from 3757 patients with pCBCL (median age, 62.0 years; 56.7% men) diagnosed between January 2000 and December 2020 using 17 Surveillance, Epidemiology, and End…

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Analysis predicts that reductions in Medicaid access could result in poorer health outcomes, including increased deaths

, 2025-05-01 21:08:00 Credit: Unsplash/CC0 Public Domain A new analysis provides evidence that reductions in access to Medicaid could increase deaths and cause financial hardship to people currently covered under an expansion of Medicaid that was implemented under the Affordable Care Act (ACA). Medicaid is a joint federal and state program that provides health insurance…

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The Hidden Toll of Food Allergies: Bullying in School

, 2025-05-01 14:15:00 Food allergies increased a child’s risk for being bullied, according to a new study published in Pediatric Allergy and Immunology.  Children who said they had been bullied also had a higher prevalence of mental health and allergic conditions such as anxiety and asthma than their peers who had allergies but had not…

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Debunked Episode 15: How Did UnitedHealth Fail to Anticipate a Rise in Medical Utilization Costs?

Stephanie Baum , 2025-05-01 21:01:00 For 17 years, UnitedHealthcare built a solid track record of always meeting or surpassing earnings expectations. Until now, that is. Last month, the national health insurer disclosed it was $2 billion off its projected revenue. MedCity News Editor-in-Chief Arundhati Parmar and Samir Batra, managing partner of HIP (Health Innovation Pitch) observed…

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How much ultra-processed food is too much? This study has the answer

, 2025-05-01 23:55:00 A global study links ultra-processed foods to tens of thousands of preventable deaths annually, especially in countries like the U.S. and the U.K. with high consumption rates, prompting urgent calls for dietary reform and public health intervention. Study: Premature Mortality Attributable to Ultraprocessed Food Consumption in 8 Countries. Image Credit: Tatjana Baibakova /…

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AI Tool for Skin Cancer Triage Gets Conditional NHS Approval

, 2025-05-01 14:34:00 An artificial intelligence (AI) system for assessing suspicious skin lesions has been conditionally recommended by the National Institute for Health and Care Excellence (NICE) for NHS use in England. The tool, called Deep Ensemble for Recognition of Malignancy (DERM), can be used while further evidence is gathered. NICE said that the aim…

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FDA fast tracks urcosimod for neuropathic corneal pain

Anthony DeFino , 2025-05-01 19:53:00 Patients in pain do not care about our clinical findings. They do not care about the pathophysiology underlying their pain. They do not care about the mechanism of action of the treatments we suggest. They do not care whether a treatment addresses the underlying cause(s) of their pain. They just…

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Monoclonal antibody provides strong real-world protection against severe RSV in infants, suggests meta-analysis

, 2025-05-01 22:30:00 Credit: Pixabay/CC0 Public Domain Nirsevimab, a monoclonal antibody, is highly effective in real-world conditions at preventing severe respiratory syncytial virus (RSV) infections in infants, suggests a meta-analysis published in The Lancet Child & Adolescent Health journal. RSV is a leading cause of serious respiratory illness in young children, particularly in the first…

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Canada Aims to Lure US Doctors North Amid Trump Turmoil

, 2025-05-01 20:52:00 John Philpott has helped physicians move between the United States and Canada for nearly three decades, mostly arranging for Canadian doctors to emigrate to the US for training or jobs.  Now, his phone is ringing off the hook from US physicians looking to move north, said the CEO of CanAM Physician Recruiting. …

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New Drug Prevents Severe RSV in Infants

Joanna Mulvaney PhD , 2025-05-01 14:24:00 A study published this morning in the Lancet Child and Adolescent Health, announces that the monoclonal antibody, nirsevimab, prevents severe respiratory syncytial virus infections in infants. In a huge review of the published evidence, epidemiologists from University of Toronto and York University, Toronto, tracked how effective nirsevimab was when…

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EHR companies push deregulation, Microsoft pushes back

STAT Staff and Mario Aguilar , 2025-05-01 20:52:00 You’re reading the web edition of STAT’s Health Tech newsletter, our guide to how technology is transforming the life sciences. Sign up to get it delivered in your inbox every Tuesday and Thursday. Last week, I flagged a proposal for “Smart Deregulation” by the EHRA, which represents medical record…

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NHS First in Europe to Offer New Subcutaneous Cancer Jab

, 2025-05-01 14:54:00 The Medicines and Healthcare products Regulatory Agency (MHRA) has approved a subcutaneous injectable version of the cancer drug nivolumab (Opdivo, Bristol Myers Squibb).  NHS England said it would be the first health service in Europe to offer this therapy. The injection takes just 3-5 min to administer, compared with 30-60 min for…

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Teladoc acquires UpLift for $30M, releases first quarter results

, 2025-04-30 20:08:00   Editor’s note: This article has been updated to include Teladoc’s first quarter 2025 earning results. New York-based virtual care company Teladoc Health announced it acquired mental health platform UpLift in a deal worth $30 million.  The acquisition reinforces Teladoc’s game plan to increase its leadership position in virtual mental health and…

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100 Days of Health Policy Upheaval

, 2025-05-01 18:40:00 The Host Members of Congress are back in Washington this week, and Republicans are facing hard decisions on how to reduce Medicaid spending, even as new polling shows that would be unpopular among their voters. Meanwhile, with President Donald Trump marking 100 days in office, the Department of Health and Human Services…

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Biotech leaders decry Trump disruptions in health and science

Jonathan Wosen , 2025-05-01 18:45:00 PALO ALTO, Calif. — At an annual meeting usually focused on the industry’s future, life science leaders couldn’t help but grapple — 100 days into President Trump’s second term — with a present clouded by uncertainty. At Stanford’s Drug Discovery Symposium, biotech bigwigs spoke openly this week about how the scientific…

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Kānuka extract shows promise in reducing organ transplant medication’s side effects

, 2025-05-01 18:44:00 Kānuka forest at Ahi-a-Te-Atua, Makarika, Tairāwhiti. Credit: Hikurangi Bioactives Limited Partnership. Researchers have identified a compound in an extract from native kānuka that may have the potential to limit the adverse effects of rapamycin, a drug primarily used as an immune suppressant in kidney transplants. “Our lab studies suggest that when this…

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