, 2025-05-07 20:49:00 The potential mechanism after blocking LSD1 inhibits novel CDK7 phospho-protein networks and STAT3 signaling ultimately promotes CD8+ T cell infiltration and activation by relieving CTLA4-mediated immunosuppression. Credit: Chinese Academy of Sciences Oral squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths, and early detection is key to improving patient outcomes. However,…
, 2025-05-07 22:59:00 Study: A 10 years update of effects of exercise on depression disorders—In otherwise healthy adults: A systematic review of meta-analyses and neurobiological mechanisms. Image Credit: People-Images.com / Yuri A / Shutterstock.com A new PLoS ONE study provides an updated review on how exercise influences depression in otherwise healthy adults. How does physical activity…
, 2025-05-07 12:47:00 TOPLINE: After a median follow-up of 99 months, salvage high-dose chemotherapy and autologous stem cell transplantation (sHDCT/ASCT) showed no survival benefit compared with continuous lenalidomide/dexamethasone in relapsed multiple myeloma. The absence of benefit was consistent across all subgroups, including patients with time to progression after frontline transplant beyond 48 months. METHODOLOGY: Researchers…
Justin Cooper , 2025-05-07 21:05:00 Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process your request. Please try again later….
Isabella Cueto , 2025-05-07 21:55:00 Isabella Cueto covers the leading causes of death and disability: chronic diseases. Her focus includes autoimmune conditions and diseases of the lungs, kidneys, liver (and more). She writes about intriguing research, the promises and pitfalls of treatment, and what can be done about the burden of disease. You can reach…
, 2025-05-07 21:11:00 Illustrations showing the 23 SERPINA1 single nucleotide polymorphisms (23-SNP AAT) assay design. Credit: CHEST Pulmonary (2024). DOI: 10.1016/j.chpulm.2024.100076 National Jewish Health researchers with the Advanced Diagnostic Laboratories have developed a molecular diagnostic test capable of accurately diagnosing a major genetic cause of chronic obstructive pulmonary disease (COPD) known as Alpha-1 Antitrypsin Deficiency…
, 2025-05-07 16:56:00 Medulloblastoma is one of the most common malignant tumors of the central nervous system (CNS) in children and adolescents. It develops in the area of the cerebellum, which is responsible for movement coordination, among other things. Medulloblastomas enlarge rapidly, often grow into surrounding tissue and can also form metastases. The wide variety…
, 2025-05-07 12:51:00 TOPLINE: In a large cohort study, each additional blistering sunburn before the age of 15 years increased melanoma risk by approximately 3%, and the associated risk was not modified by personal sun sensitivity factors, such as eye and hair color. METHODOLOGY: Researchers analyzed data from 44,021 cancer-free non-Hispanic White participants in the…
Joanna Mulvaney PhD , 2025-05-07 20:44:00 If you have been following health news in North America, you may have seen people discussing the US federal government’s Department of Health and Human Services plans to create a database of people who have autism. Understandably, the idea that a bunch of kooks and quacks led by admitted…
, 2025-05-07 19:28:00 Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . ” data-action=subscribe> Subscribe We were unable to process your request. Please try again later. If you continue to have this issue please…
Lev Facher , 2025-05-07 20:46:00 Francis Collins, the former director of the National Institutes of Health, excoriated the Trump administration’s efforts to upend federal scientific agencies on Wednesday, saying the logic behind the moves “escapes any possible explanation.” Speaking on a panel about trust in science and scientific institutions, Collins also expressed a degree of…
, 2025-05-07 20:32:00 CD8+ T cells (yellow) inside mouse lymph nodes. Scientists developed a strategy to boost these cells using mRNA vaccine technology. Credit: WEHI WEHI scientists have uncovered a promising new way to enhance the effectiveness of vaccines by tapping into the potential of a specific type of immune cell, opening the door to…
, 2025-05-07 17:45:00 A landmark study published by scientists at the University of California San Diego is redefining science’s understanding of the way learning takes place. The findings, published in the journal Nature and supported by the National Institutes of Health and U.S. National Science Foundation, provide novel insights on how brain wiring changes during…
, 2025-05-07 12:57:00 A two-part communication strategy that included discussing vaccine concerns with skeptical parents was not effective in boosting immunization among their children, according to a new study published in JAMA Network Open. Researchers tested the combined effects of two techniques to increase vaccine uptake — presumptive language and motivational interviewing — on around…
Matthew Shinkle , 2025-05-07 18:00:00 Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process your request. Please try again later….
Ed Silverman , 2025-05-07 18:58:00 Four years ago, an ambitious pharmaceutical industry venture to tackle antibiotic resistance launched to acquire or invest in small companies that can develop two to four novel antibiotics by 2030 — and replenish the global supply chain with needed treatments. The effort began with $1 billion in backing from several large…
, 2025-05-07 19:14:00 Credit: Unsplash/CC0 Public Domain Tens of millions of people in Africa are infected by parasitic worms that cause lymphatic filariasis (also called elephantiasis), a disease that leads to severe swelling and deformities of the limbs and genitals. Despite widespread treatment programs that have successfully reduced the risk of contracting lymphatic filariasis, hundreds…
, 2025-05-07 17:51:00 Motor vehicle crashes are the leading cause of death for U.S. teens. Newer vehicles and driver assistance technologies show promise in reducing crashes and injury severities. Researchers at Nationwide Children’s Hospital reviewed national fatal crash data (2016-2021) and examined the vehicle age and driver assistance technologies of vehicles driven by teen and…
, 2025-05-07 13:05:00 TOPLINE: Long-acting antiretroviral therapy (LA-ART) maintained high viral suppression for 48 weeks in patients with HIV regardless of initial viremia. METHODOLOGY: Researchers examined viral suppression for 48 weeks following the initiation of LA-ART — a cabotegravir plus rilpivirine regimen — in patients with HIV comparing those with viremia (≥ 30 copies/mL of…
Julian Herbert , 2025-05-07 13:40:00 Patient intake is time consuming and costly for medical practices and irritating for patients. Most of the time is spent on insurance matters — specifically, confirming that a person still has insurance, and which plan. But for the practice, the work doesn’t end there. While patients are generally able to…
, 2025-05-07 18:05:00 Curai Health, an AI-powered virtual clinic, is partnering with Rula Health, a behavioral health provider, to give Curai patients access to Rula’s network of licensed therapists and psychiatric providers. Curai patients will be referred to Rula’s network of more than 15,000 licensed mental health providers, including more than 100 clinical specialties in…
Stephen I. Feller , 2025-05-07 17:39:00 Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process your request. Please try again…
Adam Feuerstein , 2025-05-07 16:29:00 Adam Feuerstein is a senior writer and biotech columnist, reporting on the crossroads of drug development, business, Wall Street, and biotechnology. He is also a co-host of the weekly biotech podcast The Readout Loud and author of the newsletter Adam’s Biotech Scorecard. You can reach Adam on Signal at stataf.54….
, 2025-05-07 17:20:00 by I. Edwards The official in charge of federal food and drug safety inspections will retire May 14. Michael Rogers, associate commissioner for inspections and investigations at the U.S. Food and Drug Administration (FDA), announced his decision Monday in an email to colleagues. “I have decided to retire. It was my decision,…
, 2025-05-07 17:00:00 Our attraction to sugar has grown to an unhealthy level. The average person in the United States now consumes more than 100 pounds of the sweet stuff every year, up from 18 pounds in 1800. With new research published May 7, in Cell, Columbia University scientists have taken a major step toward…
, 2025-05-07 13:25:00 TOPLINE: Carpal tunnel syndrome (CTS) appeared more than twice as frequently in patients before rheumatoid arthritis (RA) diagnosis than in those without RA, suggesting that CTS could serve as an early indicator for RA risk. METHODOLOGY: Researchers conducted a population-based study using the Rochester Epidemiology Project, which provides comprehensive longitudinal health information…
Luidgi Faubert , 2025-05-07 14:00:00 The health care industry is a critical sector that helps save people’s lives. Sometimes, medical professionals and patients have communication barriers that can hinder that process. However, the great news is that many talented individuals and innovative technologies are ready to help you. Check out what companies provide medical interpretation…
Dr Ray O’Connor , 2025-05-07 07:30:00 Dr Ray O’Connor takes a look at the latest clinical articles on the importance of lifestyle advice in doctor-patient consultations Lifestyle Update (Part 1)I have a long-standing belief that we should include some lifestyle advice in most consultations. Over the last few months some interesting papers have been published…
, 2025-05-07 14:32:00 AI-enabled clinical data abstraction company Carta Healthcare scored $18.25 million in Series B1 financing led by UPMC Enterprises. New investors MemorialCare Innovation Fund, Tampa General Hospital Ventures and Rex Health Ventures (UNC Health’s investment fund) participated in the round, alongside existing investors Memorial Hermann Health System, Paramark Ventures, Storm Ventures, Mass General Brigham…
Sara Kellner; Bryanna Moore, PhD , 2025-05-07 15:02:00 Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process your request. Please…
Elizabeth Cooney , 2025-05-07 15:29:00 Innovation in cancer detection, treatment, and prevention is stirring excitement today, accelerated by advances in artificial intelligence and other technological tools wielded by scientists, physicians, and even patients. Still, serious gaps remain between theory and reality, experts said Tuesday. There’s a gap in access. There’s a gap between clinical guidance…
, 2025-05-07 15:00:00 Neuronal activity traces reveal how brain circuits evolve as mice learn a motor task. Left: example field of view recorded during behavior; each color marks a different neuron. Right: activity traces from selected neurons. Credit: Komiyama Lab, UC San Diego A study published by scientists at the University of California San Diego…
, 2025-05-07 14:55:00 More people are landing in the hospital with cannabis-related problems-and for many, a mental health condition is the primary issue, according to a new study published in the Journal of Studies on Alcohol and Drugs. The study, conducted in Arizona, found that between 2016 and 2021, cannabis-related hospital visits across the state…
, 2025-05-07 13:25:00 TOPLINE: Sarcopenia, a hallmark of cancer cachexia, is associated with poor outcomes in chimeric antigen receptor (CAR) T-cell therapy, which can exacerbate muscle loss through inflammatory responses. The relationship between CAR T-cell therapy, sarcopenia, and metabolism requires further investigation to improve patient outcomes. METHODOLOGY: Researchers measured skeletal muscle index from clinical images…
Nicole Clark , 2025-05-07 14:11:00 A comprehensive autism diagnostic evaluation (CDE) is a critical step in accurately identifying Autism Spectrum Disorder (ASD). It is required by Medicaid and most other insurances to qualify for certain therapies such as Applied Behavioral Analysis (ABA) therapy or access disability services. Pediatricians routinely perform autism screenings at 18- and…
Michael McHale , 2025-05-07 07:30:00 MPS said that AI must be integrated in health systems in a ‘useful and safe’ way for both patients and clinicians Guidelines for the use of artificial intelligence in healthcare should ensure that clinicians don’t become ‘liability sinks’ where they end up being held responsible for AI-influenced decisions, even when…
Stephanie Armour , 2025-05-07 09:00:00 In his March address to Congress, President Donald Trump honored a Texas boy diagnosed with brain cancer. Amid bipartisan applause, he vowed to drive down childhood cancer rates through his “Make America Healthy Again” initiative. A few days later, the administration quietly dropped a lawsuit to cut emissions from a…
Erik Swain , 2025-05-07 13:13:00 Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . ” data-action=subscribe> Subscribe We were unable to process your request. Please try again later. If you continue to have this…
Theresa Gaffney , 2025-05-07 13:09:00 Get your daily dose of health and medicine every weekday with STAT’s free newsletter Morning Rounds. Sign up here. Good morning, and happy Wednesday. I’m seeing Japanese Breakfast perform in Boston tonight. (Michelle Zauner, the band’s frontwoman, is actually Korean-American, not Japanese. I highly recommend her memoir, “Crying in H Mart.”)…
, 2025-05-07 13:00:00 Credit: Unsplash/CC0 Public Domain A drug that gained international attention for its controversial off-label use during the COVID-19 pandemic could soon be available in North Carolina without a prescription. House Bill 618, titled the “Ivermectin Access Act,” would require the state to issue a standing order by Oct. 1 allowing licensed pharmacists…
, 2025-05-07 12:44:00 A major study of around 260,000 women shows that taking the progesterone-only contraceptive pill can increase asthma attacks in some women. The research, published in ERJ Open Research, shows an increase in asthma attacks in women with asthma who are taking the progesterone-only pill and either aged under 35, or using fewer…
, 2025-05-07 12:25:00 TOPLINE: A study of 162,500 patients with uterine cancer found that survival rates varied significantly by race and geographic location, with Black patients experiencing the worst survival outcomes in areas with high and low overall diversity. METHODOLOGY: Despite known racial and ethnic disparities in uterine cancer survival in the United States, data…
Stephanie Baum , 2025-05-07 11:30:00 It is a challenging time to be an early stage medtech or biopharma company. With the federal government funding cutbacks, entrepreneurs have to be resourceful and disciplined to support their strategy and reach their goals. A webinar sponsored by Mercury on Thursday, May 8 starting at 1 pm ET will…
Dr Leslie O’Looney , 2025-05-07 07:30:00 Welcome to this week’s issue of The Week in Medicine – a round-up of all the happenings in the world of Irish medicine The Medical Protection Society have issued a statement on Artificial Intelligence (AI) stating that AI must be usable, useful and safe – not just for the…
Bram Sable-Smith , 2025-05-07 09:00:00 CRESTWOOD, Mo. — The prospect of sweeping federal cuts to Medicaid is alarming to some Missourians who remember the last time the public medical insurance program for those with low incomes or disabilities was pressed for cash in the state. In 2005, Missouri adopted some of the strictest eligibility standards…
Alex Young; Eamon N. Dreisbach; Anthony DeFino , 2025-05-06 13:28:00 Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process your…
Allison DeAngelis , 2025-05-07 11:00:00 Allison DeAngelis is the East Coast biotech and venture capital reporter at STAT, reporting where scientific ideas and money meet. She is also co-host of the weekly biotech podcast, The Readout Loud. You can reach Allison on Signal at AllisonDeAngelis.01. In January, San Francisco’s Union Square was bustling with hordes…
, 2025-05-07 10:55:00 Young adults assigned male at birth were nearly three times as likely to be diagnosed with high blood pressure if they’d been exposed to conversion therapy, a discredited practice that attempts to alter a person’s sexual orientation or gender identity, researchers report in JAMA Network Open. These young adults also had higher…
, 2025-05-07 06:20:00 A recent study conducted by researchers from Universidad San Francisco de Quito and Johns Hopkins University has revealed critical insights into the mental health of healthcare providers in Ecuador during the COVID-19 pandemic. Published in journal Disaster Medicine and Public Health Preparedness, this research examines the balance between compassion satisfaction, burnout, and…
, 2025-05-07 10:18:00 OnabotulinumtoxinA (Botox) injection and midurethral sling surgery yielded comparable symptom improvement in women with mixed stress-urgency urinary incontinence (MUI) at 6 months, a multicenter randomized study found. Surgery led to insignificantly better outcomes in the Mid-urethral Sling vs Botox A (MUSA) trial conducted by Heidi Harvie, MD, MBA, MSCE, associate professor of…