A study published in JAMA Network Open found that the quality of low-carbohydrate diets (LCDs) impacts weight change among U.S. adults. Five LCD indices were examined, and each 1-standard deviation increase in different LCD scores was linked to varying weight changes. Specifically, animal-based and unhealthy LCD scores were associated with greater weight gain, while vegetable-based…
A new research paper was published in Oncotarget’s Volume 14 on December 20, 2023, entitled, “The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies.” The study aimed to summarize current knowledge underlying the mechanism of action (MOA) of GFH009, a…
The market for dietary supplements in the United States is growing rapidly, with consumers spending over $48 billion in 2021 and projected to grow 5% annually. At least half of U.S. adults take dietary supplements. Despite enthusiasm, experts worry about adverse effects and lack of evidence for many supplements. However, supplements like prenatal folic acid…
Regular moderate to vigorous physical activity is associated with larger brain size in key regions, including gray and white matter and the hippocampus, according to new research. The study analyzed MRI brain scans from 10,125 healthy adults and found that increased days of moderate to vigorous activity correlated with larger normalized brain volume in several…
A recent study from the Karolinska Institutet in Stockholm found that the rate of hospitalizations for RSV infection in children is higher than for the omicron strain of SARS-CoV-2 or influenza. RSV causes mild symptoms like a cold, but severe cases can lead to pneumonia and bronchiolitis. The research revealed that hospitalization rates for RSV…
Clear aligners have been found to provide stable positive overbite in patients with anterior open bite. This means that they can effectively correct the alignment of the upper and lower teeth, leading to improved overbite. The use of cookies on the website is also mentioned, indicating that they are used for analytics, advertising, and site…
The FDA has issued a new alert regarding the use of promethazine hydrochloride, an old drug used for allergic reactions, motion sickness, and post-operative nausea and vomiting. The alert specifically covers the administration of the drug as a deep intramuscular injection or a slow intravenous injection, recommending the former to reduce the risk of severe…
The National Perinatal Epidemiology Centre (NPEC) will hold its annual study day on January 19, titled “From pre-pregnancy to postpartum: understanding maternal adverse outcomes”. The event will be a hybrid event held at the Midlands Hotel in Portlaoise, featuring speakers such as Prof Krish Nirantharakumar and Deirdre Daly discussing various research projects. Other speakers include…
The REHAB-HF trial found that a physical intervention produced similar improvements in physical function and health-related quality of life (HR-QOL) among Black and White individuals. The study involved a translational, tailored, progressive, 1-on-1 multidomain physical rehabilitation intervention compared with attention control patients for older individuals hospitalized with acute decompensated heart failure. The intervention resulted in…
Boston-based healthcare company Heranova Lifesciences, focusing on women’s reproductive health, pregnancy, and menopause, has launched with $13.5 million in seed and seed+ funding. The company offers diagnostic testing and therapeutics for endometriosis, bacterial vaginosis, genetic testing, and fertility. They plan to develop non-invasive endometriosis tests and therapeutic programs for bacterial vaginosis and endometriosis with the…
In this content, Dan Weissmann talks about the issue of hospitals suing patients who can’t afford to pay their medical bills. He discusses his conversation with Scott Purcell, CEO of ACA International, on the effects of these lawsuits on patients. The content also covers the findings of investigations into hospital bill lawsuits in Maryland, Wisconsin,…
The study found that contamination of health care environments near patients with C. auris occurs quickly, often within 4 hours of disinfection. Most C. auris carriers were found to be co-colonized with at least one bacterial multidrug-resistant organism. This highlights the need for broadly effective interventions to reduce colonization burden and environmental contamination against multiple…
Conflict zones have caused a high spike in multidrug-resistant infections in Ukraine and Gaza. Historically, conflicts have always created perfect conditions for drug resistance. An increasing historical number of global conflicts signify that the rise of drug-resistant diseases may have been underestimated. The appearance and growth of drug resistance have mainly been driven by the…
Shree Datta, a consultant obstetrician and gynaecologist in London, UK, critiques a study by Muraca and colleagues on trauma during operative vaginal deliveries. She points out that the severity of perineal tears is influenced by ethnicity, specifically South Asian and Black women being at higher risk. Datta also emphasizes the importance of addressing maternal consent…
Scientists at the University of Lausanne have identified Tcf7+ CD8+ T cells as precursors to stem-like central memory T cells (TCM cells) and have tracked their development in response to viral infection. These T cells are essential to the adaptive immune system and play a critical role in generating long-lasting immunity. The identification of TCM…
A study from Harvard T.H. Chan School of Public Health suggests that low-carbohydrate diets with healthy fats and plant-based proteins contribute to slower long-term weight gain in comparison to low-carb diets with unhealthy fats and animal proteins. Using data from over 120,000 participants over a period of 32 years, the study found that low-carb diets…
Sleep deficit is a global problem, with Omagh, Northern Ireland residents being kept awake by a persistent hum and vibration. The Worldwide Hum is only heard by 2-4% of people and is related to low-frequency noise from human or industrial sources such as traffic, ventilation systems, and airplanes. Low-frequency noise disrupts sleep, causing increased light…
In Quebec, wait lists for surgery, including cancer operations and nonelective surgery, are increasing. The number of patients waiting for cancer surgery has risen from 4160 in January to 4401 in October, and elective surgery wait lists have grown by about 2000 patients. This has led to concerns about patients being lost due to long…
Chronic Wasting Disease (CWD), known as “zombie deer disease,” is a fatal neurological infection affecting deer, elk, and moose. It has been reported in 31 U.S. states. CWD is a progressive illness that causes brain and spinal cord damage and is transmitted through body fluids. Although there are no known cases in humans, concern exists…
Bristol Myers Squibb announced plans to acquire RayzeBio for USD 4.1 billion. This move aligns with Bristol Myers Squibb’s strategy to expand its oncology pipeline. RayzeBio’s expertise in targeted radiopharmaceuticals for cancer treatment will complement Bristol Myers Squibb’s existing portfolio. The acquisition is expected to enhance the company’s ability to develop innovative therapies for patients…
The RSNA 109th Scientific Assembly and Annual Meeting in Chicago focused on innovation in radiology, with discussions shaping the future of the field in 2024 and beyond. Major trends highlighted at the conference included the integration of artificial intelligence (AI) in radiology, a renewed focus on health equity, and efforts to enhance the patient experience….
A study published in JAMA Neurology found that children with Multiple Sclerosis (MS) are less likely to experience progression independent of relapse activity (PIRA) or relapse-associated worsening over a decade of follow-up compared to individuals with adult- or late-onset MS. However, PIRA increases rapidly in this patient population beginning in young adulthood. The study included…
Executives in the digital health space shared the most significant events in healthcare in 2023, including the rise of generative AI, the impact of ChatGPT, the fall of Silicon Valley Bank, and Medicaid disenrollment. The launch of generative AI, particularly ChatGPT, and the release of Apple Vision Pro were unexpected and are poised to fundamentally…
Healio’s coverage of research on ultraprocessed foods covers the significant impact these foods have on nutrition and health. Studies have shown a link between ultraprocessed foods and conditions like obesity, cardiovascular disease, depression, and mortality. However, some experts argue that there is not yet enough evidence to support policies against their consumption. The top ultraprocessed…
Apple Watches were facing a sales ban due to a feature similar to Masimo’s pulse oximeter. The ITC had issued the import ban in October, which went into effect on Tuesday after President Biden declined to veto it. However, the U.S. Court of Appeals approved Apple’s request to continue selling the devices while reviewing the…
Walking wasn’t a popular pastime until the late 1700s. The term “pedestrianism” originally had a sporting connotation. It became a leisure activity in the 1780s, popularized by famous walkers such as Charles Dickens and the Lake poets. City streets during the 1800s were dirty and unsanitary, creating jobs for street sweepers and pure finders. These…
Researchers discuss using the gut microbiome in personalized medicine. Personalized medicine based on an individual’s gut microflora can overcome limitations of current approaches and provide more accurate diagnostics and treatments. Microbiome analysis has shown promise in diagnostics and treatment of diseases, and AI and machine learning can be used to analyze and predict patient responses…
Ulcerative colitis (UC) is a long-term illness characterized by unpredictable symptoms that come and go over time. Around half of Americans with UC are in remission, with three types of remission – clinical, endoscopic, and deep. Deep remission does not mean you are cured, and there is still a chance of future flare-ups. It is…
The FDA has approved an expanded label for the Barostim neuromodulation system for patients with heart failure, based on longer-term clinical data from the BeAT-HF trial. The system is indicated for patients with class III or II heart failure with certain criteria. The device stimulates carotid baroreceptors and is implanted below the collarbone. The FDA’s…
As we approach the end of 2023, it’s important to reflect on the past year and set achievable goals for a better and healthier 2024. Many people make New Year’s resolutions, but most fail within weeks due to unrealistic goal setting. It’s important to set specific, achievable, and measurable goals. For a healthier New Year,…
Unbound bilirubin levels can predict the likelihood of acute bilirubin encephalopathy in infants. This suggests that monitoring unbound bilirubin may help identify infants at risk for this serious condition. The article also mentions the use of cookies for analytics, advertising and site improvement, and directs readers to their Cookie Policy and Settings for more information….
An experimental drug from Cytokinetics has shown promising Phase 3 results in improving heart function during exercise for patients with obstructive hypertrophic cardiomyopathy (oHCM), a rare cardiovascular disease. The drug, aficamten, demonstrated a significant increase in peak oxygen uptake compared to a placebo and had a consistent treatment effect across patient subgroups. The drug works…
The study published in JAMA Cardiology found that patients receiving the Ross procedure for aortic valve disease had excellent survival rates after 30 years, similar to that of the general population. The study included 108 patients in the UK who underwent the procedure between 1994 and 2001. The primary outcome was survival relative to the…
President Biden declined to veto a product ban that prevents Apple from selling its newest smartwatches, the Series 9 and Ultra 2, in the U.S. This ban was implemented by the ITC to protect medtech company Masimo, which accused Apple of stealing trade secrets related to blood oxygen level measurement technology. Apple has filed an…
Robert F. Kennedy Jr.’s presidential campaign is built on conspiracy theories and anti-vaccine sentiments. He has obtained significant financial backing and support based on these theories, although they have been proven to be false. Kennedy comes from an elite background, with a history of environmental advocacy before becoming focused on vaccines. His efforts to legitimize…
The results from a phase 3 trial showed that lonapegsomatropin, a once-weekly human growth hormone therapy, led to greater reduction in trunk fat mass and increase in total body lean mass compared to placebo. In a comparison with a once-daily therapy, lonapegsomatropin also provided similar body composition benefits. The therapy also had similar safety and…
Cytokinetics announced that their experimental drug, aficamten, significantly improved exercise capacity for patients with obstructive hypertrophic cardiomyopathy (HCM). The study enrolled 300 patients, and after 24 weeks of treatment, those receiving aficamten showed significant improvements in peak oxygen uptake and met the study’s primary goal. The trial also met all 10 of its secondary endpoints….
Researchers have uncovered a fundamental mechanism that lets neurons know when and how to form complex connections between and among brain cells, contributing to normal brain development. The transcription factor CREB is required for the brain to learn and form memories, and its interaction with CBP stimulates gene expression during brain development. Neuronal activity increases…
A study of two large cohorts of 600,000 participants in the US and UK showed that the presence of amyloid deposits in the cerebral blood vessels, known as cerebral amyloid angiopathy (CAA), is linked to isolated nontraumatic subdural hemorrhages. The study should lead to a better understanding of both conditions and suggests that subdural hemorrhage…
The newest treatments for relapsed/refractory multiple myeloma are discussed in the content. It is likely to cover the latest advancements in medical treatments for this condition, potentially including new drugs, therapies, or clinical trials. This information could be beneficial for patients, caregivers, or healthcare professionals seeking the most up-to-date options for managing relapsed or refractory…
The European Union is implementing stricter regulations for the use of artificial intelligence. The proposed AI Act aims to ensure AI safety while respecting basic rights and democracy. The legislation will apply to large AI companies and includes protective measures, restrictions on biometric identification systems, and bans on social scoring and certain AI technologies. There…
Research has found that the timing of meals can significantly impact heart health. The study recommends eating an early breakfast before 8 a.m. and having dinner before 8 p.m. to reduce the risk of cardiovascular disease. Analyzing data from over 100,000 participants, the study found that eating breakfast later in the day and having dinner…
The Medical Bulletin from 27 December 2023 states that the website uses cookies for analytics, advertising, and site improvement. By continuing to use the site, users agree to the use of cookies. More information can be found in the Cookie Policy and Cookie Settings. Source link
AstraZeneca has acquired Gracell Biotechnologies for $1 billion, with the potential for additional payments based on regulatory milestones. This acquisition will help AstraZeneca address the challenges of cell therapy manufacturing in cancer treatment and expand into autoimmune diseases. Gracell has developed technologies to shorten manufacturing times and improve the effectiveness of cell therapies, including a…
A study published in Pediatrics found that hybrid immunity, from previous COVID-19 infection and recent vaccination with a third mRNA dose, is the most protective against infection for students in middle and high school. The study analyzed data from students in Utah, with a median age of 16, and found that two and three doses…
Carrum Health has collaborated with Florida Cancer Specialists & Research Institute to provide employers in Florida with breast cancer care services. The San Francisco-based company offers a digital platform for self-funded employers to purchase specialty care, focusing on surgical and cancer care. Through their Center of Excellence network, Carrum highlights high-quality surgical centers across the…
The top cornea-related articles on Healio in 2023 featured the FDA approval of Vevye for dry eye disease and the efficacy of azithromycin in treating meibomian gland dysfunction. Other articles included the approval of Vyznova cell therapy for bullous keratopathy and tips for navigating secondary dry eye disease. Additionally, a video perspective discussed the importance…
Food-as-medicine programs that address food insecurity and diet-related chronic diseases are gaining attention, but there is little evidence of their effectiveness. A clinical trial was conducted on a program that prescribes healthy food to food-insecure patients with uncontrolled type 2 diabetes. The results showed high engagement in the program, improvement in self-reported diet, and a…
Painful periods are common, and digestive changes are often experienced around this time. There are many treatments for period pain, but researchers are learning more about the role of food in influencing inflammation in the body. Foods that may relieve period pain include those high in omega-3 fatty acids, vitamin D, and vitamin E. However,…
A study from Hebrew University’s Hadassah Medical School introduces a new model suggesting that disrupted RNA editing in pancreatic beta cells may trigger an inflammatory response similar to early-stage type 1 diabetes. This challenges the long-held belief of viral involvement and could have implications for T1D treatments and cures. This perspective offers a new insight…