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Scaling up API processes with Dr. James Mencel’s guidance

In this interview, NewsMed talks to Dr. James Mencel’s Guidance about Scaling Up API Processes. Could you introduce yourself and your experience in the pharmaceutical industry? I obtained a B.S. in Chemistry at Fairfield University in 1979 and a Ph.D. in organic chemistry in 1984 at Yale University and then began my career in cardiovascular…

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7 Most Effective Exercises

There’s no mystery about exercise: You get out of it what you put in. But you don’t have to work out for hours each day. You just need to work smart. Not all exercises are created equal. Some are more efficient than others, whether they target multiple muscle groups, are OK for various fitness levels,…

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Study Identifies Risk Factors for TBI in Elderly

TOPLINE: In older patients with minor head injury, Glasgow Coma Scale (GCS ≤14), high-risk injury, vomiting, and retrograde amnesia are recognized as risk factors for clinically important traumatic brain injury (TBI). METHODOLOGY: In this retrospective study, researchers evaluated 290 patients (≥65 years) with a head injury and GCS score ≥13 presenting to the ED at…

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Rompiendo una promesa: déficit en California podría frenar aumentos a cuidadores de personas con discapacidades

SACRAMENTO, California – Las familias de personas con discapacidades intelectuales y del desarrollo dicen que el gobernador Gavin Newsom no está cumpliendo con un aumento programado para los trabajadores que cuidan de sus seres queridos. Sus defensores advierten sobre posibles demandas contra el estado si los servicios para estas personas se vuelven más difíciles de…

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Study finds that the transport of mRNAs into axons along with lysosomal vesicles prevents axon degeneration

Image of BORCS7-KO i3Neurons stained for various organellar markers. BORCS7-Knockout human i3Neurons show axonal swellings due to accumulation of defective mitochondria-associated autophagosomes. Credit: De Pace et al. RNA granules, sites for the storage, transport, and regulation of RNA molecules within cells, are transported along axons and then translated locally, far from the cell body. Recent…

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Ulcerative Colitis: Social Relationships and Dating

Your friendships enrich your life. They’re good for your health, too. Studies show that people who have good friends and good relationships are healthier, happier and may live longer. That’s why maintaining your social life might be the perfect supplement to your ulcerative colitis care. “Whether you have IBD or not, social isolation is not…

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Substance Abuse and Firearm Injuries Increase Mortality

TOPLINE:  Opioid and substance abuse patients with firearm injuries encounter increased mortality rates and incur higher costs, with limited discharge to outpatient resources, highlighting the urgent need for improved screening and treatment. METHODOLOGY: Researchers investigated the association between substance use disorders (opioid and others) and gun violence in 25,218,381 patients (age, ≥ 18 years) presenting…

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Merck, Pfizer, EyePoint, and more

Want to stay on top of the science and politics driving biotech today? Sign up to get our biotech newsletter in your inbox. Good morning! Today, we learn more about studying tumors at the International Space Station, study the buzzy Amgen weight loss drug MariTide, and find a lawsuit in which a former Spark Therapeutics executive is…

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Personalized screening approach may better predict preeclampsia in the first trimester of pregnancy

A new screening algorithm for preeclampsia combining maternal history, ultrasound data and several tests for blood markers may better predict the majority of preeclampsia cases in the first trimester of pregnancy, when it may still be preventable, according to new research published today in Hypertension, an American Heart Association journal. Preeclampsia is the most dangerous form of high…

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Evidence Builds to Support Colchicine in Treating ASCVD

NEW YORK — New insights into colchicine’s disruption of the pathway that contributes to arterial inflammation and new clinical studies of the drug could pave the way toward greater use of the anti-inflammatory drug in patients with or at risk for atherosclerotic cardiovascular disease (ASCVD), researchers said at the 4th Annual Cardiometabolic Risk in Inflammatory…

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There’s Still Time to Register for MedCity INVEST

Join MedCity News and nearly 300 healthcare investors, startups, and innovative-minded executives in Chicago at the Ritz Carlton on May 21-22 for MedCity INVEST 2024. The conference is the premier boutique healthcare investment event in the U.S.  Equal parts networking and curated panels covering the latest healthcare investment trends, women’s health and AI, as well as…

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Could Better Inhalers Help Patients, and the Planet?

Miguel Divo, a lung specialist at Brigham and Women’s Hospital in Boston, sits in an exam room across from Joel Rubinstein, who has asthma. Rubinstein, a retired psychiatrist, is about to get a checkup and hear a surprising pitch — for the planet, as well as his health. Divo explains that boot-shaped inhalers, which represent…

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Researchers unveil mechanism enhancing cellular fitness against aging and neurodegeneration

Researchers at Duke University Medical Center discover a mechanism to enhance the fitness of cells against aging and neurodegenerative diseases. This finding will pave the way for novel therapeutic approaches in neuroprotection against aging-related disorders and neurodegeneration. Durham, North Carolina; USA; April 30, 2024. A research study by scientists at Duke University Medical Center uncovered…

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Complex Regional Pain Syndrome treatment shows promise for recovery

Complex Regional Pain Syndrome (CRPS) is a chronic and debilitating pain disorder, typically considered lifelong with limited treatment options. Now, groundbreaking research finds that early detection and effective treatment can lead to significant recovery within 18 months, offering hope to millions of people worldwide. Led by NeuRA’s Centre for Pain IMPACT and conducted in partnership with the University of South Australia,…

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Correct Dx of Cancer Treatment Skin Effects Evaluated

SAN DIEGO — Compared with medical oncologists, dermatologists were more likely to correctly classify and grade dermatologic adverse events from cancer therapies, results from a multicenter survey showed. “New cancer therapies have brought a diversity of treatment-related dermatologic adverse events (dAEs) beyond those experienced with conventional chemotherapy, which has demanded an evolving assessment of toxicities,”…

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Review Addresses Skin Manifestations of Cystic Fibrosis

TOPLINE: Cutaneous manifestations of cystic fibrosis (CF) include palmar wrinkling, nutrient deficiency dermatitis, vascular disorders, and reactions to CF treatments. METHODOLOGY: Patients with CF, caused by a mutation in the CF Transmembrane Conductance Regulator (CFTR) gene, can develop a variety of diverse dermatologic manifestations. Researchers reviewed the literature and provided their own clinical experience regarding…

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Omega-6 fatty acids could reduce the risk of bipolar disorder

Omega-6 fatty acids, commonly found in eggs, poultry, and seafood, could reduce the risk of bipolar disorder, according to a world-first study from the University of South Australia. Using Mendelian randomization, a powerful causal inference method, researchers tested 913 metabolites across 14,296 Europeans, finding 33 (mostly lipids) were associated with risk of bipolar disorder. Bipolar disorder is a debilitating mood disorder characterized…

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WHI reports key findings on postmenopausal women’s health

Researchers from the Brigham and colleagues report on the long-term follow-up of the largest study of women’s health in the U.S., shedding light on the role of menopausal hormone therapy, calcium and vitamin D supplementation, and a low-fat dietary pattern among postmenopausal women. More than 1.1 billion women worldwide are postmenopausal. A newly published review paper…

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Strategies for future pandemic response based on mpox experience

Targeted support for marginalized communities, strong public messaging and a properly coordinated Government approach led by Ministers are amongst the recommendations contained in a new evidence-based article examining how the UK should respond to future pandemics. A new article published by Policy@Manchester examines how the UK can learn the lessons of mpox to respond to…

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Revolutionizing treatment for neurological conditions with 3D printed surgical implants

Clever bio-inks that sit inside the human body and restore damaged neurons could cure a whole swathe of diseases in the next 20 years: conditions that have baffled scientists and clinicians for centuries. Think blindness, deafness, chronic pain, epilepsy, motor neurone disease, and Parkinson’s disease. According to University of South Australia materials engineer Associate Professor Matthew Griffith, these…

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Janssen-Cilag seeks European approval for guselkumab in ulcerative colitis and Crohn’s disease treatment

Janssen-Cilag International NV, a Johnson & Johnson company, today announced it has submitted applications to the European Medicines Agency (EMA) seeking to expand the Marketing Authorization Application for TREMFYA® (guselkumab) to include the treatment of adult patients with moderately to severely active ulcerative colitis and moderately to severely active Crohn’s disease. The submission included data from…

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Intensive Therapy Beneficial in T2D and Early Hypertension

TOPLINE: Women with type 2 diabetes (T2D) whose hypertension was diagnosed earlier in life are at a greater risk for cardiovascular diseases (CVDs) and may benefit from intensive antihypertensive therapy. METHODOLOGY: Age-related elevation in blood pressure begins earlier in life and faster in women than in men, particularly in the presence of cardiometabolic risk factors…

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New influenza vaccine strategies aim to enhance protection with T-cell responses

In a recent review published in the journal Nature Reviews Immunology, researchers discussed the limitations of current influenza vaccines and the potential for future vaccines to induce both T-cell responses and antibodies for enhanced protection. They examined the strategies to develop influenza vaccines with broad strain specificity and long-term efficacy, covering protection requirements, immune response…

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Many Patients With Advanced MCC Not Receiving Immunotherapy

PHOENIX — Immunotherapy has revolutionized outcomes for patients with metastatic Merkel cell carcinoma (MCC). However, findings from a new study suggest that many patients who are eligible for immunotherapy are not receiving this treatment, despite guideline recommendations, and survival outcomes are better at high-volume centers. The study has important implications, commented study author Shayan Cheraghlou,…

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Raw meat-based diet for pets linked to drug-resistant bacteria, prompting concerns over public health risks

In a recent study published in the journal Eurosurveillance, researchers investigated the potential role of the increasingly popular ‘raw meat-based diets (RMBDs)’ as reservoirs and human and pet infection risks for bacteria such as Salmonella sp. and pathogenic Escherichia coli. Unlike conventionally processed pet food, the majority of which undergoes various stages of heat or…

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Evaluating ChatGPT for structured data extraction from clinical notes

In a recent study published in npj Digital Medicine, researchers evaluated ChatGPT’s ability to extract structured data from unstructured clinical notes. Study: A critical assessment of using ChatGPT for extracting structured data from clinical notes. Image Credit: TippaPatt / Shutterstock.com AI in medicine Large-language-based models (LLMs), including Generative Pre-trained Transformer (GPT) artificial intelligence (AI) models like…

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Study finds no fetal growth benefits from LPG cooking in resource-limited settings

In a recent study published in The Lancet Global Health, researchers investigate whether using liquefied petroleum gas (LPG) to limit human exposure to home air pollution during pregnancy affects fetal growth. Study: Cooking with liquefied petroleum gas or biomass and fetal growth outcomes: a multi-country randomised controlled trial. Image Credit: Irina Gutyryak / Shutterstock.com The influence…

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Pickleball injuries and prevention

Credit: Pixabay/CC0 Public Domain The popularity of pickleball has exploded in the last few years, and according to a recent report, so have injuries attributed to the relatively new sport. Dr. Sanj Kakar, a Mayo Clinic orthopedic surgeon who specializes in hand and wrist disorders, says there are two main injuries he sees due to…

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Consultmed moving its e-referral software to InterSystems’s IRIS for Health and more briefs

Consultmed to replatform to InterSystems’ IRIS for Health Consultmed is moving its referral management software to InterSystems IRIS for Health data platform.  The move comes as the health IT provider looks to “do integrations at scale.” Hosted on Microsoft Azure, Consultmed enables referral management, virtual triage, Advice & Guidance, secure messaging, digital patient forms, requests…

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Dentists warn of growing trend in e-scooter accidents

A recent study published in the British Dental Journal reports an overall increase in electric scooter-related dental injuries in the United Kingdom between 2020 and 2022. Study: E-scooter-related dental injuries: a two-year retrospective review. Image Credit: Skylines / Shutterstock.com Dental injuries and electric scooters Traumatic dental injuries account for about 5% of all bodily injuries. In addition…

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Long-term impact of COVID-19 on body composition explored

Following the coronavirus disease 2019 (COVID-19) pandemic, which was caused by the emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), many survivors have experienced long-term symptoms collectively referred to as long COVID or post-acute sequelae of SARS-CoV-2 (PASC). Long COVID symptoms may include but are not limited to, fatigue, neurological symptoms, alterations in…

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