TOPLINE: Overall, patients with solid tumors who receive an investigational cancer drug experience small progression-free survival (PFS) and overall survival benefits but much higher toxicity than those who receive a control intervention. METHODOLOGY: The view that patients with cancer benefit from access to investigational drugs in the clinical trial setting is widely held but does…
To combat impactful challenges such as financial strain, staff burnout, resource scarcity, and other operational inefficiencies, hospitals and health systems need to adopt new methods of optimization. One of the most crucial weapons organizations have in the fight against inefficiency is their own awareness. By elevating their awareness level, hospitals and health systems can not…
Healthcare-focused cybersecurity company Blackwell Security has secured $13 million in a funding round led by General Catalyst and Rally Ventures. The company also hired Geyer Jones as its first chief executive officer. Jones previously served as chief operating officer at healthcare IoT security company Cylera and chief strategy officer at RSA. The Michigan-based company works…
President Joe Biden counts among his accomplishments the record-high number of people, more than 21 million, who enrolled in Obamacare plans this year. Behind the scenes, however, federal regulators are contending with a problem that affects people’s coverage: rogue brokers who have signed people up for Affordable Care Act plans, or switched them into new…
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Top of the morning to you, and a fine one it is. There is nothing like being greeted with clear blue skies and cool breezes upon waking up today on the Pharmalot campus. Birds are chirping, butterflies are flurrying, and official mascots are barking. And we are similarly engaged in early-in-the-day rituals of our own…
Credit: Journal of Clinical Investigation (2024). DOI: 10.1172/JCI170118 B-cells infiltrating the lungs may be responsible for one of the most common complications in lung transplantation, which can lead to rejection, according to a study published in the Journal of Clinical Investigation. Roughly 2,500 people receive lung transplants each year, according to the U.S. Department of…
Sapio ELN release 24.5 features multiple improvements, including enhanced CRISPR design with multiple sequence alignment and integration with small molecule research. Image Credit: Nuttapong Punna/Shutterstock.com BALTIMORE, MD, May 7, 2024 — Sapio Sciences, the science-awareTM lab informatics platform, today announced Sapio ELNSM release 24.5. The latest release of its electronic laboratory notebook software includes an advanced…
Darker skin tones were underrepresented in images on patient-facing online educational material about skin cancer, an analysis of photos from six different federal and organization websites showed. Given the known disparities patients with darker skin tones face in terms of increased skin cancer morbidity and mortality, this lack of representation further disadvantages those patients by…
In his 2015 State of the Union address, President Barack Obama announced a precision medicine initiative that would later be known as the All of Us program. The research, now well underway at the National Institutes of Health, aims to analyze the DNA of at least 1 million people across the United States to build a diverse health database. The key word there is “diverse.” So…
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The presence of H5N1 avian influenza virus, better known as bird flu, among dairy cows in Texas — the second largest producer of dairy cattle — was first confirmed in late March. By then, H5N1 had likely been circulating among dairy cows for months. Six weeks later, the nine states responsible for more than one-quarter…
Credit: Pixabay/CC0 Public Domain Research into how the human brain stores information could lead to treatments for people who struggle with everyday tasks. Professor Jan Buitelaar, an expert in neurodevelopmental illnesses, is intrigued by a possible link between attention deficit hyperactivity disorder—or ADHD—and memory. While genes play a big part in ADHD, Buitelaar thinks the…
In a recent study published in JAMA Network Open, researchers compared the risk of cancer in children born by medically assisted reproduction (MAR) to infants conceived naturally. Study: Medically Assisted Reproduction and Risk of Cancer Among Offspring. Image Credit: Antonio Guillem/Shutterstock.com Background Childhood cancers are a global health problem, with early onset after birth and embryologic traits…
PHOENIX — There is a high prevalence of emotional and physical burden associated with being a Mohs surgeon, particularly among women and younger surgeons, according to new findings. In addition, most surgeons did not feel prepared to manage or prevent these symptoms. “Our study highlights the need to implement ergonomic training and emotion-focused coping skills,…
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Tombs and Bridges have developed a new method that improves on the standard method of differential privacy to allow health care data sharing while maintaining patient privacy. Credit: ORNL, U.S. Dept. of Energy In industries such as health care, where data generation grows by 47% each year, information collected within electronic health records could help…
Talayeh Razzaghi, an assistant professor of industrial and systems engineering at the University of Oklahoma, has been awarded a Faculty Early Career Development Program award from the National Science Foundation for her work titled “Personalized Maternal Care Decision Support System for Underserved Populations.” Known as a CAREER award, Razzaghi was awarded $496,732 to research machine…
Extreme heat, wildfires, and particulate matter not from wildfires were the most studied climate issues in conjunction with increased respiratory care, based on data from more than 60 studies. Previous research has shown that fossil fuel combustion and climate change are threats to respiratory health, but the direct impact of climate on respiratory healthcare has…
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Credit: Pixabay/CC0 Public Domain The brain circuits that underlie alcohol craving and heavy drinking share some similarities between men and women, but also some key differences, a new Yale study reveals. Using functional magnetic resonance imaging (fMRI), Yale researchers have observed that after viewing stress– or alcohol-related images (as opposed to “neutral” images), the brains…
A new imaging technique tested in patients could improve the evaluation of cardiac conditions and undiagnosed chest pain. Researchers from Imperial College London’s Department of Bioengineering and Faculty of Medicine worked alongside academics from UCL to produce sub-millimeter resolution images of cardiac micro-vessels. The non-invasive new imaging technique was tested on four human patients. Existing…
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“No use of substances” sign. Credit: Journal of Studies on Alcohol and Drugs Teenagers are less likely to drink, smoke or use drugs when their parents keep tabs on their activities—but not necessarily because kids are more likely to be punished for substance use, suggests a new study in the Journal of Studies on Alcohol…
Qi “Tony” Zhou, a researcher in Purdue University’s College of Pharmacy has received a $2.4 million grant from the National Institutes of Health to fight lung infections that have established a resistance to antimicrobial drugs. Zhou is an associate professor in the Department of Industrial and Molecular Pharmaceutics, a Faculty Scholar and a faculty…
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In 1682 children followed up from age 11 to 24 years, increased sedentariness from childhood through young adulthood caused excessive heart enlargement, irrespective of obesity or hypertensive category. Light physical activity effectively reversed the risk of premature heart damage. Credit: Andrew Agbaje. An increase in sedentary time from childhood causes progressing heart enlargement, a new…
In a groundbreaking advancement in gastrointestinal health, researchers from Johns Hopkins University have developed the Multifunctional Ablative Gastrointestinal Imaging Capsule (MAGIC) – a game-changer in esophagus surveillance and interventions. MAGIC combines the latest optical coherence tomography (OCT) technology with an ultracompact endoscope camera and an ablation laser, offering unprecedented capabilities in esophageal imaging and potential…
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Credit: Pixabay/CC0 Public Domain On behalf of the Swedish Gender Equality Agency, researchers Lena Dahlberg and Mariam Kirvalidze have done a scoping review of informal caregiving and loneliness. More specifically, the report examines loneliness in spousal caregivers aged 65 years and older, the factors that increase the risk of loneliness in this group, the consequences…
In a recent study published in the journal Science Advances, researchers investigated the impact of early-life tobacco exposure on aging-related diseases. They found that in-utero tobacco exposure is associated with increases in the rate of biological aging. Their findings indicate that reducing early-life tobacco exposure is crucial for improving healthy aging, as it significantly influences…
TOPLINE: Higher levels of physical activity are associated with a decreased risk of developing inflammatory bowel disease (IBD), particularly Crohn’s disease (CD). METHODOLOGY: Because previous observational studies on the association between physical activity and IBD risk have yielded a wide range of results and conclusions, researchers conducted a systematic review and meta-analysis to estimate the…
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Credit: Pixabay/CC0 Public Domain Gallstones are hardened deposits of digestive fluid, called bile, in your gallbladder. They range in size from as small as a grain of sand to as large as a golf ball. Dr. Irving Jorge, a Mayo Clinic general surgeon, says people who experience pain and other symptoms from gallstones usually require…
In a recent study published in the journal Psychiatry Research Case Reports, researchers present the case of a 27-year-old African American woman with a history of schizoaffective disorder suffering from fibromyalgia, a neurological condition characterized by chronic pain. The woman reported self-medicating with potent, dispensary-procured cannabis in gradually increasing dosages to suppress her pain, but…
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Credit: Unsplash/CC0 Public Domain Investigators at Dana-Farber Cancer Institute have examined the historical evolution of Community Outreach and Engagement initiatives at both the National Cancer Institute (NCI) and National Cancer Institute-Designated Cancer Centers (NCI-DCCs). The team’s assessment of these activities and recommendations for future efforts were recently published in CA: A Cancer Journal for Clinicians….
In a recent study published in The Lancet, researchers examined the public health impact of the World Health Organization’s Expanded Program on Immunization (EPI). The World Health Assembly established the EPI in 1974, marking a significant commitment to extend the benefits of vaccination to all. The WHO launched the initiative to initially vaccinate children against…
TOPLINE: Clip-assisted anchoring lowers the migration rate of fully covered self-expandable metal stents (FCSEMS) in patients with biliary strictures undergoing endoscopic retrograde cholangiopancreatography (ERCP), with no increase in procedure-related adverse events. METHODOLOGY: FCSEMS are widely used in patients with malignant biliary strictures; however, a significant drawback is the occurrence of proximal or distal migration, with…
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Study reveals VR’s potential in revolutionizing depression treatment, offering hope to millions worldwide. Credit: JMIR Publications/Creative Commons Attribution (CC-BY) A recent study published in JMIR Mental Health sheds light on the promising role of virtual reality (VR) in treating major depressive disorder (MDD). Titled “Examining the Efficacy of Extended Reality–Enhanced Behavioral Activation for Adults With…
In a recent study published in the journal Nature, researchers clarified how the body-brain axis, via specific neural circuits, senses and regulates inflammatory responses, possibly providing new approaches to treating immune disorders. Study: A body–brain circuit that regulates body inflammatory responses. Image Credit: Kampan / Shutterstock Background Maintaining a balanced immune response is vital for an organism’s…
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Credit: CC0 Public Domain Researchers at Bar-Ilan University have unveiled a technology that promises to improve cancer treatment decisions based on a patient’s biopsy. The pioneering biological research and development measures changes in immune system cells adjacent to cancer cells, providing crucial insights into the patient’s immune response and potentially enhancing the effectiveness of immunotherapy….
Smoldering multiple myeloma (SMM), a potential precursor to multiple myeloma (MM), has become a controversial topic. Some people diagnosed with SMM will live their whole lives without ever developing MM, while others will develop it quickly. My approach to treating SMM takes into account what its history can teach us about 1) how advancements in…
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Credit: Pixabay/CC0 Public Domain Epilepsy is a neurological condition characterized by recurrent seizures, which can lead to various psychological problems. While most cases are idiopathic, some may result from brain injury, stroke, or genetic mutations. In children, seizures can have different origins and sensitivity to drugs, requiring careful consideration by doctors. Symptoms range from mild…
In a recent study published in Microorganisms, researchers discuss current evidence on Candida auris, an emerging multidrug-resistant yeast. Study: Candida auris Outbreaks: Current Status and Future Perspectives. Image Credit: Kateryna Kon / Shutterstock.com What is C. auris? On October 25, 2022, the World Health Organization (WHO) published a list of nineteen priority fungal pathogens that pose significant clinical…
Attention-deficit/hyperactivity disorder (ADHD) in adults is independently associated with an increased risk for dementia with Lewy bodies (DLB), dementia, and nonamnestic mild cognitive impairment (naMCI), results of a new study showed. “Determining whether there is an association between ADHD and subsequent conversion to a specific type of dementia is important. This information could generate opportunities…
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