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Top-Line Results Positive for Lilly’s Oral Orforglipron

, 2025-04-18 11:59:00 Orforglipron, Eli Lilly’s investigational oral glucagon-like peptide 1 receptor agonist (GLP-1 RA), achieved positive phase 3 results for both A1c and weight loss, according to top-line data released by the company. The findings came from Lilly’s ACHIEVE-1, the first of seven phase 3 trials examining the safety and efficacy of orforglipron in…

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My rare disease doesn’t even have a single name

Taylor Coffman , 2025-04-18 08:30:00 In 2022, I gave birth to a healthy baby girl and triggered a wildly violent chain of events: multiple organ failure, hemorrhaging, blood clots in many of my major organs, and a rattled medical team working tirelessly to keep me alive. For five weeks, I rotated in and out of…

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Opioid control policies linked to drop in domestic violence

, 2025-04-19 03:15:00 A new study led by the University of South Florida reveals opioid control policies may offer broader public health benefits, including reducing instances of domestic violence. As policymakers continue to grapple with the opioid epidemic, this study highlights the power of research to inform effective public policy. The research conducted by USF…

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Lack of Bladder Control Tied to Emotional Health in Kids

, 2025-04-18 12:00:00 TOPLINE: According to a new study, children with urinary incontinence (UI) had worsening emotional problems over time, and changes in emotional problems predicted the risk for UI in the future. METHODOLOGY: Researchers analysed data of 8188 children aged 6.5 to 9 years (50.7% girls) from the ALSPAC study to assess the potential…

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Non-Enhanced CT Rarely Aids Haemorrhage Detection

, 2025-04-18 12:00:00 TOPLINE: Non-enhanced CT scans were deemed helpful in only 4% of haemorrhage cases, primarily in gastrointestinal bleeding, while contributing substantially to the overall radiation exposure. An analysis of 75 patients revealed that non-enhanced CT series accounted for more than 37% of the total radiation dose. METHODOLOGY: Researchers conducted a retrospective analysis of…

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Discovery shows potential for brain aging and disease therapies

, 2025-04-18 17:16:00 Neural stem cells can develop into various types of neurons and non-neuronal cells but with aging they don’t differentiate as easily. Credit: Matthew Modoono/Northeastern University Northeastern University scientists have discovered that a protein in the human brain could potentially be used to grow new neurons in the lab and enhance brain processes…

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The dual role of microRNAs in lung cancer progression and suppression

, 2025-04-18 18:48:00 Lung cancer (LC) is a major global health issue, with high mortality rates and limited therapeutic options. It is primarily categorized into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Despite significant advancements in diagnostic techniques, LC remains highly lethal, largely due to late-stage diagnosis and aggressive metastasis. Recent…

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Appendix Removal With Therapy May Help Maintain UC Remission

, 2025-04-18 12:00:00 TOPLINE: Among patients with ulcerative colitis in remission who had been treated for a disease relapse, those who underwent laparoscopic appendicectomy combined with standard medical therapy had lower relapse rates at 1 year than those who received standard treatment alone. METHODOLOGY: Researchers conducted a pragmatic randomised controlled superiority trial (2012-2022) at 22…

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NIH discontent, hearing loss, dementia, AI

Theresa Gaffney , 2025-04-18 12:52:00 Get your daily dose of health and medicine every weekday with STAT’s free newsletter Morning Rounds. Sign up here.Good morning, and happy Friday! Today’s the last day you’ll hear from me for a couple weeks. I’m taking off on a big trip with some of my best friends. But don’t worry,…

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Evaluating hydronidone for the treatment of chronic hepatitis B-associated liver fibrosis

, 2025-04-18 18:57:00 Background and aims Liver fibrosis is a key process in the progression of chronic liver diseases. However, there are currently no drugs specifically designed to treat liver fibrosis. Our Phase 2 trial of hydronidone for the treatment of chronic hepatitis B (CHB)-associated liver fibrosis showed that adding hydronidone to entecavir resulted in…

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New FMF Recommendations Tackle Drug Resistance and Fertility

, 2025-04-18 12:10:00 A multidisciplinary team has released new evidence-based recommendations for the management of familial Mediterranean fever (FMF). Jointly endorsed by the European Alliance of Associations for Rheumatology (EULAR) and the Pediatric Rheumatology European Society, the recommendations are the first update to the 2016 EULAR guidelines. Although rare, FMF is the most common monogenic…

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Low-income patients with diabetes are more likely to experience insurance instability, researchers find

, 2025-04-18 17:35:00 Credit: Pixabay/CC0 Public Domain An Oregon Health & Science University-led study reveals that low-income adults with diabetes are more likely to go in and out of health insurance, and that insurance instability is even worse for those with complex needs. Published in the Journal of American Family Medicine, the study examined electronic…

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Lower temperatures increase the risk of gastroenteritis among Rohingya refugees in Bangladesh

, 2025-04-18 19:08:00 Colder temperatures are linked with increased risk of diarrhea among Rohingya refugees in Bangladesh, emphasizing the need for climate-sensitive health strategies in refugee settings. A new study by scientists at Hokkaido University has found that lower temperatures significantly increase the risk of gastroenteritis among Rohingya refugees living in Bangladesh’s Kutupalong and Nayapara…

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Weight Stigma Remains a Barrier to Patient Care

, 2025-04-18 12:35:00 Obesity has historically been regarded as a moral failing, and people with obesity describe being seen as deficient, lazy, and/or undeserving of respect, lacking willpower and self-discipline, and gluttonous. Negative judgments about obesity persist not only in society at large but also in healthcare settings, despite the American Medical Association’s declaration of…

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On Autism, Kennedy Turns Against Science and Reality

Tarena Lofton , 2025-04-18 22:00:00 During his first news conference as Health and Human Services secretary, Robert F. Kennedy Jr. on April 16 ticked off things he thinks kids with autism will never do, including paying taxes, holding a job, and going on a date. Kennedy’s comments go against science and reality.  This slide presentation…

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NIH halts new grant awards to universities with frozen funds

Anil Oza and Megan Molteni , 2025-04-18 21:24:00 Megan Molteni reports on discoveries from the frontiers of genomic medicine, neuroscience, and reproductive tech. She joined STAT in 2021 after covering health and science at WIRED. You can reach Megan on Signal at mmolteni.13. Embattled universities whose funding from the National Institutes of Health has been…

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Research identifies new cut-off points for overweight and obesity in male athletes

, 2025-04-18 22:10:00 Credit: Unsplash/CC0 Public Domain New research presented at this year’s European Congress on Obesity (ECO 2025, Malaga, Spain, 11–14 May) shows that the internationally recognized body mass index (BMI) cut-off points greatly overestimate overweight and obesity in male athletes. The study, from Italy, also proposes new cut-off points for overweight and obesity…

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Zinc found in glassware may impair embryo development in IVF

, 2025-04-18 19:17:00 1. Overview The research team discovered that glassware used to manipulate and culture fertilized eggs in the fields of assisted reproductive technology (ART), livestock farming, and basic research contains toxic substances that interfere with the development of fertilized eggs (embryos). The team also identified the toxic substance as zinc, and developed a…

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Complexities of Vitamin D in CKD Require Individualization

, 2025-04-18 12:57:00 When it comes to issues of vitamin D in chronic kidney disease (CKD), core certainties include that most patients with CKD have dysregulated 25-hydroxy vitamin D (25[OH]D) and nutritional supplementation can increase those levels. Beyond that, complexities abound, with evidence fraught with confounders regarding who may or may not benefit from supplementation….

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‘Usually Only Seen in Elite Bodybuilders’

, 2025-04-18 15:20:00 A TikTok video featuring a ChatGPT response has gone viral after it declared President Donald Trump‘s reported physical results “virtually impossible,” and compared them to those of elite-level bodybuilders. In a viral TikTok video posted by @coughbuddy, ChatGPT is shown analyzing Trump’s alleged physical stats—specifically, a 215-pound weight at 6’3″—and responding that…

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HealthMed, Podimetrics partner to help high-risk patients with diabetes

, 2025-04-18 17:47:00 Podimetrics, a company that helps patients with diabetes prevent serious complications, is teaming up with HealthMed, an employee health and wellness platform. HealthMed aims to integrate Podimetrics’ SmartMat technology into its portfolio of benefits intended for large employers, hospitals and municipalities. The company also provides employee wellness and mental health programs. Podimetrics’ SmartMat…

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‘Tell That to a Diabetic’

, 2025-04-18 19:37:00 As Dr. Mehmet Oz was sworn in as head of the Medicare and Medicaid Services, he encouraged Americans to reduce drug spending by simply staying healthy. “It is your patriotic duty — I’ll say it again — the patriotic duty of all Americans to take care of themselves,” Oz said during the…

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Why One Healthcare Founder Never Took Venture Capital

Katie Adams , 2025-04-18 19:20:00 The digital health funding market has been way up and way down over the past five years. As this roller coaster starts to settle down, one thing is clear to Randy Bolyga: that the industry is shifting toward prioritizing profitability over aggressive expansion. Bolyga is the CEO of medical software…

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GLP-1 therapies show potential for treating rare genetic disorder Bardet-Biedl syndrome

, 2025-04-18 17:35:00 Credit: Monell Chemical Senses Center A Monell Chemical Senses Center study published this week in the Journal of Clinical Investigation offers renewed hope for individuals living with Bardet-Biedl Syndrome (BBS), a rare genetic disorder characterized by early-onset obesity, compulsive eating, and cognitive impairments. The Monell team and colleagues identified that GLP-1 receptor…

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Neural fingerprints reveal how teamwork and deep focus interact

, 2025-04-18 17:26:00 Summary: A collaborative study by researchers from Toyohashi University of Technology and California Institute of Technology (Caltech) introduces a groundbreaking algorithm that maps individual brain activity in a multi-dimensional space. This “neural fingerprint” reveals stable, long-term neural traits that interplay with transient brain states during social interactions. The study demonstrates that individuals…

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