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BALTIMORE — An ambitious effort to cure HIV with CRISPR genome editing fell short in an early clinical trial, investigators announced Friday morning. In the study, run by Excision BioTherapeutics, researchers tried to use the gene editing tool to address a chief reason HIV has been so hard to cure. While antiviral drugs can clear…
Shibley Rahman honorary visiting professor, University of Liverpool; honorary research fellow, University College London Rahman S. Caring for a loved one can make you a better clinician BMJ 2024; 385 :q1035 doi:10.1136/bmj.q1035 Source link
Credit: cottonbro studio from Pexels Measuring the total mass of fat in the arms could potentially predict which women and men over 50 are at risk of spinal fracture, according to research presented at the 26th European Congress of Endocrinology, held 11–14 May, in Stockholm. The findings may help identify high-risk individuals with a more…
Heather Crivilare was a month from her due date when she was rushed to an operating room for an emergency cesarean section. The first-time mother, a high school teacher in rural Illinois, had developed high blood pressure, a sometimes life-threatening condition in pregnancy that prompted doctors to hospitalize her. Then Crivilare’s blood pressure spiked, and…
May 10, 2024 – When we’re young, we take our macula for granted. At the center of our retina – the deepest layer of the eye that’s chock-full of photoreceptors and that confers color to our world – the macula is like a high-resolution camera. As light hits our eyes, the retina’s macula recasts our…
A mouth rinse used to identify oral microbiome composition could serve as an early-detection tool for gastric cancer, new evidence suggests. Researchers found distinct bacterial composition differences in patient samples that point to the potential for oral microbial signatures to be used as biomarkers for assessing gastric cancer risk. “Too many patients are being diagnosed…
A new company emerged out of stealth mode this week at the SynBioBeta conference in San Jose. The startup, called CybergenX, is seeking to integrate AI-powered cybergenetic technology into the synthetic biology field. The company, which was born out of the University of Edinburgh, is developing cybergenetic technology to enhance researchers’ understanding of what is…
Novel targeted therapies are transforming patient outcomes, but further research is required to address unmet clinical needs Paolo Ghia, Professor of Medical Oncology at the Università Vita-Salute San Raffaele in Milan, Italy, outlines the changing treatment landscape of chronic lymphocytic leukaemia (CLL). His work has supported many patients worldwide and he continues to teach, research…
The Food and Drug Administration (FDA) has granted Orphan Drug designation to bitopertin for the treatment of erythropoietic protoporphyria (EPP). EPP is a rare, life-threatening disease caused by a deficiency of the enzyme ferrochelatase, which leads to an accumulation of protoporphyrin IX. The disease is characterized by intense pain, edema, burning sensations, and in rare…
GenAI radiology workflow company Rad AI announced it secured $50 million in Series B funding led by Khosla Ventures, bringing the company’s total raise to more than $80 million. WiL (World Innovation Lab) participated in the round, alongside existing investors OCV Partners, Gradient Ventures (Google’s AI-focused fund), Kickstart Fund and ARTIS Ventures. Rad AI offers…
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Hello there and happy Friday from STAT’s London outpost, where the weekend is mere hours away. STAT reporter Andrew Joseph here, filling in for Mr. Pharmalot for the day. Spring has fully sprung here in the U.K., and our weekend plans include plenty of park time, and if we’re being honest, likely some time at…
The world is on track to meet the World Health Organization’s target of a billion people having better health by 2025, the UN agency’s 2023 report has found.1 Improved air quality, access to water and sanitation, and hygiene measures were the biggest drivers of global health improvement, said the report, which covered 174 countries in…
Credit: Unsplash/CC0 Public Domain When it comes to improving the lives of children with genetic conditions, medical research often focuses solely on the children. But there is an equally important population in need of research that a faculty member at the University of Colorado Department of Medicine is highlighting—the caregivers. “We need to think very…
Machine learning enables cheaper and safer low-power magnetic resonance imaging (MRI) without sacrificing accuracy, according to a new study. According to the authors, these advances pave the way for affordable, patient-centric, and deep learning-powered ultra-low-field (ULF) MRI scanners, addressing unmet clinical needs in diverse healthcare settings worldwide. Magnetic Resonance Imaging (MRI) has revolutionized healthcare, offering…
May 10, 2024 — Cow udders have the same receptors for flu viruses as humans and birds, raising concerns that cows could become “mixing vessels” that help the bird flu virus spread between people. That’s according to new research conducted by scientists at the University of Copenhagen and St. Jude Children’s Research Hospital in Memphis and…
NEW ORLEANS — When using tirzepatide (Zepbound, Eli Lilly) to treat obesity, patience may pay off. New post hoc data from Lilly’s SURMOUNT-1 trial of people with overweight or obesity but not diabetes suggest that the drug will almost always produce at least 5% weight loss eventually, even among slow responders. “Some obesity treatment guidelines…
Scientists hope that C100 can be developed into an effective adjuvant for use in cancer therapies A new vaccine ‘booster’ may be able to trigger an immune response in tumours and open the door to the development of new cancer treatments. Scientists from Trinity College Dublin have discovered that a vaccine adjuvant – or ‘booster’…
The Food and Drug Administration (FDA) has accepted the Biologics License Application (BLA) for a proposed biosimilar to denosumab. Denosumab is a RANK ligand inhibitor that is approved under the brand name Prolia for the treatment of postmenopausal women with osteoporosis at high risk for fracture; to increase bone mass in men with osteoporosis at…
A study performed by Google Research in collaboration with Google DeepMind reveals the tech giant expanded the capabilities of its AI models for Med-Gemini-2D, Med-Gemini-3D and Med-Gemini Polygenic. Google said it fine-tuned Med-Gemini capabilities using histopathology, dermatology, 2D and 3D radiology, genomic and ophthalmology data. The company’s Med-Gemini-2 was trained on conventional medical images encoded…
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WASHINGTON — The federal government will provide livestock farms as much as $28,000 apiece to bolster protective measures and testing for the avian flu virus spreading among dairy cows, officials said Friday. The Agriculture Department also allotted $98 million to aid states restricting the interstate movement of affected cattle, and health officials announced they would…
Jeffrey K Aronson Centre for Evidence Based Medicine, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK Follow Jeffrey on X (formerly Twitter): @JKAronson The term “generic” derives from an IndoEuropean linguistic root, GN, which implies both knowing and begetting, and comes down to us via the Latin noun genus, a class…
Credit: Cancer Cell (2024). DOI: 10.1016/j.ccell.2023.12.015 A study appearing in Cancer Cell uncovers the evolutionary dynamics of glioblastoma recurrence through proteogenomic analysis, offering potential therapeutic avenues. The research team, led by Professor Jason K. Sa from Korea University College of Medicine’s Department of Biomedical Informatics and Professor Jong Bae Park from the National Cancer Center,…
A new study released to mark the 70th anniversary of Sir Roger Bannister’s sub-four-minute mile record has revealed the first 200 runners to follow in his footsteps also share another remarkable trait. The study from investigators in Australia and Canada found the 200 elite runners live on average almost five years longer than the general…
NEW ORLEANS — Teprotumumab (Tepezza) works equally well in both older and younger patients with thyroid eye disease (TED) and regardless of TED duration, new data suggest. TED is an autoimmune disease characterized by orbital inflammation and expansion of fat and muscles around the eyes, resulting in proptosis, diplopia, pain, redness, and swelling. Many of…
Clinical trials today require more patient involvement than ever before. Yet longer, more frequent site visits or participation that requires extensive travel can impact a patient’s willingness to participate in and remain in a clinical trial over the long term. As a result, patient recruitment and retention can be a challenge for sites and pharmaceutical…
Emergency facilities in Ennis and Nenagh closed 15 years ago Health authorities will determine if a second emergency department is required in the Mid-West after the Minister for Health announced a review into emergency care capacity in the region. The HIQA assessment will consider the case for a second ED for the region in light…
Treatment with tirzepatide was associated with significant weight loss in obese and overweight adults, according to phase 3 data. Tirzepatide is an investigational once-weekly, dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that integrates the actions of both incretins into a single molecule. GIP is believed to complement the effects of GLP-1…
GenAI radiology workflow company Rad AI announced it secured $50 million in Series B funding led by Khosla Ventures, bringing the company’s total raise to more than $80 million. WiL (World Innovation Lab) participated in the round alongside existing investors OCV Partners, Gradient Ventures (Google’s AI-focused fund), Kickstart Fund and ARTIS Ventures. Rad AI offers…
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The result is the most-detailed digital map, or “connectome,” of the human brain ever created. On Thursday, Lichtman and his partners unveiled the results of their efforts in the prestigious journal Science, and also posted to the internet renderings of the human brain unlike any ever seen. They came complete with a program that allows viewers to move through…
The UK National Screening Committee has recommended including a test for Edwards’ syndrome as part of the fetal anomaly screening programme for women who miss, or do not complete, the first trimester combined test.1 The committee agreed that the quadruple test is accurate enough to be added to the antenatal screening pathway for Edwards’ syndrome…
Credit: Unsplash/CC0 Public Domain Picture two people, both suffering from a serious mental illness requiring hospital admission. One was born in Australia, the other in Asia. Hopefully, both could be treated on a voluntary basis, taking into account their individual needs, preferences and capacity to consent. If not, you might imagine they should be equally…
What does it take to help a parent avoid and manage burnout? Experts at Ohio State University came together to design a study on triggers of parental burnout and reported the results of their survey in a report published online. They offer methods and solutions that could help connect struggling parents and outline ways to…
Cognitive behavioral therapy (CBT) is superior to mindfulness-based cognitive therapy (CT) for reducing symptom severity in patients with prolonged grief disorder, results from a randomized trial showed. While patients receiving grief-focused CBT had a superior response compared with those receiving MT, participants in both groups experienced a significant reduction in symptoms 6 months after treatment….
Terence Cosgrave is not the Messiah – he’s a very naughty boy My Messiah complex has not been well of late. My experiences of the last month have led me to a place where I can well understand (and sympathise with) the frustration of previous incarnations of (obviously false) ‘Messiahs’. The first complaint would be…
HealthDay News — Fasting during pregnancy is associated with lower birth weight; however, dietary composition outside of fasting hours modifies this association, according to the results of a study published online Feb. 15 in PLOS ONE. Fabienne Pradella, PhD, from Johannes Gutenberg-University in Mainz, Germany, and colleagues surveyed 326 Muslim patients who delivered their babies in Mainz….
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Hired someone new and exciting? Promoted a rising star? Finally solved that hard-to-fill spot? Share the news with us, and we’ll share it with others. That’s right. Send us your changes, and we’ll find a home for them. Don’t be shy. Everyone wants to know who is coming and going. And here is our regular feature in which…
There is only limited evidence that the current approach to continuous observation of patients at risk of harming themselves when on hospital wards is effective, an investigation has concluded.1 The report from the Health Services Safety Investigations Body (HSSIB) said that sometimes healthcare providers get false reassurance from a patient being on continuous observation, believing…
Credit: Sơn Bờm from Pexels The largest-ever trial of a psychological intervention for patients with motor neuron disease (MND), conducted by researchers at the University of Sheffield and UCL, found that acceptance and commitment therapy (ACT) improves overall quality of life, when integrated alongside existing care. MND is a progressive, neurodegenerative disease with no cure….
The World Health Organization (WHO) publishes the first global guidelines to prevent the occurrence of bloodstream and other infections caused by use of catheters placed in minor blood vessels during medical procedures. Poor practices in the insertion, maintenance, and removal of these catheters carry a high risk of introducing germs directly to the bloodstream, which…
Targeted video games could help reduce symptoms of attention-deficit/hyperactivity disorder (ADHD) and depression in children and adolescents, results of a new review and meta-analysis suggested. Although the video game–based or “gamified” digital mental health interventions (DMHIs) were associated with modest improvements in ADHD symptoms and depression, investigators found no significant benefit in the treatment of…
Navigation challenges are the top reason consumers stop seeing healthcare providers, while experience issues are the main reason consumers leave their health insurer, a new survey found. The Accenture report, released last week, surveyed more than 9,700 insured consumers and 8,000 consumers who sought or received care in the prior year. The survey is a…
In this article, tailored specifically for Medical Consultants, we delve into the unique financial considerations you face, and the expert solutions provided by Biograph Wealth Advisors Through a real-life case study and comprehensive insights, we explore mortgage options, including incorporating private income, leveraging contract changes like Sláintecare, maximising overpayment benefits, and the advantages of partnering…
HealthDay News — Transcendental Meditation is a viable and effective intervention to decrease burnout and depression among academic physicians, according to results of a study published online January 26 in the Journal of Continuing Education in the Health Professions. Marie Loiselle, PhD, from Maharishi International University in Fairfield, Iowa, and colleagues studied the effects of the…
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WASHINGTON — The Centers for Disease Control and Prevention recommended this week that dairy and poultry farms with infected animals supply protective gear to workers in a bid to stave off human transmission of the H5N1 virus. The challenge now is making it happen. The CDC has no legal authority to order those protective measures,…