#medicine

A study found that adding immune checkpoint inhibitors to neoadjuvant chemotherapy improved pathologic complete response and event-free survival in certain patients with early-stage breast cancer. However, there was no benefit observed with adjuvant immune checkpoint inhibitor therapy. The study analyzed nine clinical trials with over 5,000 patients, showing that immune checkpoint inhibitors were particularly beneficial…

Robert F. Kennedy Jr. is poised to join Trump’s team and potentially get a top health care job. However, his history of vaccine skepticism has raised concerns in the industry and among GOP health officials, who fear it could overshadow genuine health care goals. Kennedy’s involvement in choosing leaders for FDA, NIH, and CDC has…

Louisa Polak, a retired general practitioner and visiting researcher at the University of Cambridge, expresses concern about oversimplification of challenges in avoiding unwanted medical treatment in the event of a patient’s death. She questions the effectiveness of proposals such as an enforceable “duty of candour” which may lead to unintended adverse consequences for clinicians. Polak…

A study presented at the Infectious Diseases Society of America’s annual meeting found that vaccination rates for influenza, SARS-CoV-2, and RSV are lower among individuals with higher social vulnerability index (SVI) and Black race. The study examined data from 341,029 patients with acute respiratory infections and discovered that vaccination rates decreased as SVI quartiles increased,…

Waymark published a study in the New England Journal of Medicine evaluating their early intervention model in Medicaid, finding reduced hospital and ER visits and improved care quality. The study involved over 64,000 patients covered by two Medicaid health plans in Washington and Virginia. Waymark’s community-based care teams and technology connect rising-risk patients with preventive…

The FDA has approved foscarbidopa and foslevodopa for 24-hour continuous subcutaneous infusion to treat motor fluctuations in adults with advanced Parkinson’s disease. This new non-surgical regimen provides continuous delivery of levodopa throughout the day. Studies have shown superior improvement in motor fluctuations with the continuous infusion compared to oral medications. The most common adverse reactions…

A recent study suggests that taking short breaks during walks can help burn more calories compared to long, uninterrupted sessions. The study found that short bouts of walking or climbing stairs require more oxygen and energy, leading to 20-60% more oxygen consumption compared to continuous walking. This is due to the increased energy required to…

The healthcare industry is undergoing digital transformation, improving data exchange and providing clinicians with more data through AI tools and advanced analytics. However, this transformation has led to increased risks of patient data exposure. A recent report identified over 14,000 unique IP addresses globally exposing sensitive medical information on the public internet, with open ports…

HSE West and North West are offering three General Practitioner positions in the Aran Islands, Co. Galway. There are two positions available on Inis Mór with a GMS Panel Size of approximately 170, and one position on Inis Óirr / Inis Meáin with a GMS Panel Size of approximately 240. Enhanced terms and conditions apply…

Governor Gavin Newsom of California affirmed abortion access, supported legislation mandating insurance coverage for in vitro fertilization, and signed various health-related bills. He also endorsed the operation of cannabis cafés and rejected some bills citing cost concerns. Newsom approved laws related to health care, medical debt, mental health, abortion, aging, violence prevention, substance use, youth…

Wastewater surveillance can detect the spread of H5 influenza before official confirmation in birds, cows, and humans. Monitoring wastewater may help public health officials respond to outbreaks more quickly. A study presented at IDWeek revealed that detecting H5 viruses in wastewater could have provided early warning of highly pathogenic avian influenza before cases were confirmed…

In 2023, prescription medicines purchased in the U.S. under the 340B Drug Discount Program reached $63 billion, a 23.4% increase from the previous year. This program requires drugmakers to offer discounts of about 25% to 50% (or even higher) off outpatient drugs to hospitals and clinics serving lower-income patients. Over 12,000 entities participate in the…

The EU has updated its air quality standards by merging two directives into one and aligning the limits on harmful pollutants with those recommended by the World Health Organization. The revised Ambient Air Quality Directive, adopted on October 14 by the European Council, imposes stricter limits on pollutants in the air. This move aims to…

A University of Michigan-led study found that 4.22 million U.S. adults had glaucoma in 2022, with 1.49 million experiencing vision impairment. The study, published in JAMA Ophthalmology, revealed demographic and geographic disparities in glaucoma cases, with Black adults showing the highest prevalence at 3.15%. The prevalence of glaucoma increased with age, ranging from 1.11% in…

Researchers led by the Hubrecht Institute and Roche’s Institute of Human Biology have developed strategies to identify regulators of intestinal hormone secretion. These hormones play key roles in digestion and appetite. By studying rare enteroendocrine cells (EECs) in the gut, the team identified new tools to explore potential ‘nutrient sensors’ on these cells and how…

The FDA has approved zolbetuximab for the first-line treatment of locally advanced unresectable or metastatic HER2-negative gastric or gastroesophageal junction adenocarcinoma that is claudin 18.2 positive. This monoclonal antibody targets claudin 18.2 and triggers immune responses that kill cancer cells. Approval was delayed due to manufacturing plant issues but has since been resolved. Zolbetuximab is…

Researchers have found that COVID-19 vaccination is associated with a higher risk of facial palsy, particularly within the first 28 days of receiving the vaccine. Facial palsy, also known as Bell’s palsy, causes temporary weakness or paralysis of the facial muscles. Although the exact cause is unknown, experts believe that viral infections, autoimmune mechanisms, or…

Waymark’s community-based interventions were found to lower hospital and emergency department visits while also improving care quality, according to a study published in the New England Journal of Medicine Catalyst. Waymark works with health plans and providers to support Medicaid patients by connecting them with resources in their community. The study evaluated outcomes for over…

Blackrock Clinic in Europe performed the first procedure using the Varipulse™ Pulsed Field Ablation (PFA) platform for atrial fibrillation treatment. The Varipulse™ platform uses electric voltage instead of thermal energy to combat AF, leading to potentially greater efficiency and safety outcomes. The technology has been approved earlier in the year and has shown positive results…

Residents of Asheville, North Carolina felt safe from climate disasters before Hurricane Helene hit. The storm caused historic flooding, downed trees, and power outages, leading to health risks for those reliant on medical equipment. Over two weeks later, many are still without electricity. The aftermath includes debris, boil-water advisories, and challenges accessing clean water. FEMA…

At the American Academy of Ophthalmology meeting, Jason Betz discussed how preoperative and perioperative variables can predict ocular pain following refractive surgery. Approximately 800,000 refractive procedures are performed each year, with some patients experiencing persistent ocular symptoms like burning, discomfort, dryness, and photophobia. Betz conducted a study with 109 patients who underwent LASIK or PRK…

Have you made recent changes in your team, such as hiring someone new, promoting a rising star, or filling a difficult position? Share the news with us so we can share it with others. Don’t hesitate to let us know who is coming and going. In our latest feature, Aligos Therapeutics has appointed Hardean Achneck…

The BMA’s General Practitioners Committee for the UK has voted to stop hiring physician associates in general practice and phase out existing roles. At a meeting on October 17, a majority of members voted in favor of a motion stating that the role of PAs in general practice was “fundamentally unsafe.” The motion prohibits new…

A study published in the Clinical Kidney Journal found no significant differences in all-cause or cardiovascular mortality between patients undergoing hemodialysis with a prescription of dialysate calcium at 1.50 versus 1.25 mmol/L. The research, which included over 12,000 patients, indicated that while there was a higher unadjusted risk for all-cause mortality with the higher dosage,…

A new study from the Institute of Neurosciences at the University of Barcelona reveals a molecular mechanism affecting RNA processing in Alzheimer’s patients. The RTP801 protein was found to disrupt the activity of the tRNA ligase complex, impacting protein synthesis and neuronal survival. This discovery may lead to new therapies for neurodegenerative diseases by targeting…

The European Medicines Agency has recommended marketing authorization for a new hybrid formulation of buprenorphine for opioid drug dependence treatment. Buprenorphine Neuraxpharm, a sublingual film, is intended for use in adults and adolescents 15 years and older. It should be part of a comprehensive treatment plan. This new hybrid medicine is similar to Subutex but…

A recent study published in the International Journal of Epidemiology suggests that standing for extended periods may not offer long-term cardiovascular benefits and could increase the risk of circulatory issues, such as deep vein thrombosis and varicose veins. The study, which analyzed data from 83,013 UK adults over seven to eight years, found that for…

In the biopharma industry, digital strategy has shifted towards omnichannel engagement due to decreased in-person access to healthcare professionals (HCPs). This transformation aims to create better digital experiences and streamline content creation and approval processes. Companies are now integrating digital tools with modular Digital Experience Platforms (DXPs) to accelerate content creation, ensure compliance, and improve…

Sinn Féin TD Mairead Farrell highlighted Irish Medical Times’ revelation of six HSE construction projects going over budget by €17 million in a Dáil question to Tánaiste Micheál Martin. Farrell criticized the government’s wasteful spending on these projects, emphasizing the importance of delivering necessary health infrastructure within budget. Martin defended the government’s record, citing the…

Lisa Trumble, a patient in Massachusetts, was told by CVS that they would no longer provide the IV nutrition she needs to survive at home. This decision impacted 25,000 patients in the U.S. who rely on parenteral nutrition. The situation was worsened by a hurricane that affected the production of essential fluids. With a lack…

A Breathlessness Clinic that combines pulmonary and palliative care has been found to improve access to treatments for diverse and underserved populations with advanced lung disease. Established by Rebecca Anna Gersten, MD in 2022 at Johns Hopkins Hospital, the clinic aims to provide targeted symptom management and advance care planning. Research presented at the CHEST…

Alex Chern, a researcher and fellow in otology-neurotology at Johns Hopkins University, has a personal connection to hearing loss and music. He started playing the violin as a child, which helped with his hearing loss diagnosis. After a car accident, music became essential to his recovery. Now, Chern studies the link between hearing loss, cognition,…

A woman in her 40s was found to have multi-coloured crystals in the vitreous cavity of her left eye during a routine diabetic screening examination. She had a history of proliferative diabetic retinopathy with recurrent vitreous bleeds but was asymptomatic. The crystals were identified as synchysis scintillans, a rare condition where small, freely moving cholesterol…

A new study has identified four main categories of cancer mutations that cause drug resistance, providing insights for drug development and potential second-line therapies. By using CRISPR gene editing, researchers mapped the genetic landscape of drug resistance in colon, lung, and Ewing sarcoma cancers. The study found that mutations can lead to drug resistance, drug…

New research reveals heightened postprandial glucose and insulin levels in women using androgenic oral contraceptives, posing metabolic risks. A Nutrients study examined the impact of combined OCPs on glycemic response, linking OCP with metabolic syndrome (MetS) rise in women, impacting cardiometabolic health globally. The study gathered young women on monophasic OCPs, highlighting glucose homeostasis disparities…

Students in medical school are increasingly turning to digital study apps to help them absorb and retain complex medical information needed to pass licensing exams. Popular study tools include UWorld, AMBOSS, Sketchy, Boards & Beyond, Pathoma, Anki flashcards, NBME self-assessments, and AMA practice questions. These apps offer a mix of practice questions, videos, interactive review…

Whooping cough cases are increasing in the U.S., reaching the highest levels in a decade, due to the pandemic and waning immunity. The U.S. CDC reports over 10,000 cases annually, five times higher than last year. Symptoms include cold-like symptoms, intense coughing fits, vomiting, fatigue, and difficulty breathing. Vaccination is the best prevention method. The…

CVS Health has expanded beyond being just a retail pharmacy, acquiring Aetna, Signify Health, and Oak Street Health in recent years. The company also owns CVS Caremark, one of the largest pharmacy benefit managers in the country. However, CVS is facing challenges in profitability, particularly in its Medicare Advantage business. The company’s decision to focus…

HSE West and North West is currently seeking 5 General Practitioners for a position in Strokestown, Co. Roscommon. The GMS Panel Size is approximately 1,350, and the closing date for applications is Monday, 4th November, 2024. Interviews will be held on Wednesday 13th November, 2024. For more information and to apply for these positions, interested…

A report from the Urban Institute suggests that living in a community with consolidated hospitals could increase the likelihood of individuals incurring medical debt, as hospitals often raise prices when they gain market power. Factors such as uninsured residents and chronic illnesses also contribute to medical debt. While the American Hospital Association criticized the report…

Alex Lopez of Ace Vision Group discusses laser scleral microporation for presbyopia in a Healio Video Perspective from Eyecelerator@AAO. The GenII device aims to improve near vision without affecting distance vision in patients with presbyopia. The company plans to conduct a study in the U.S. in 2026, with potential commercial availability in 2027. Lopez believes…

A coalition of unions, consumer groups, and public interest organizations are urging the Federal Trade Commission to challenge a $16.5 billion deal where Novo Nordisk’s parent foundation would acquire Catalent, a leading contract drug manufacturer. The coalition is concerned that the acquisition may harm competition and reduce patient access to popular diabetes and weight loss…

The government and Eli Lilly are partnering to conduct a five-year real-world trial called Surmount-Real UK to evaluate the weight loss drug tirzepatide’s impact on health outcomes and employment status. The study will focus on weight loss, prevention of obesity-related complications, quality of life, and changes in employment status and sick days. The trial will…

A recent multi-state study published in The Lancet analyzed real-world data on the effectiveness of the RSV vaccine in older adults. The research showed that the vaccine provided approximately 80% protection against severe respiratory illness, hospitalization, and death in adults aged 60 and older. The study, conducted by the CDC’s VISION Network, used electronic medical…

A recent study published in BMC Public Health found that 65.8% of diabetic men suffer from erectile dysfunction, highlighting the need for early detection and better diabetes control. This condition can have physical, mental, and emotional impacts on men and is associated with conditions like cardiovascular disease and depression. Diabetes causes nerve damage and affects…

In a recent letter to users of MiniMed 600 and 700 series insulin pumps, the company recommends carrying backup batteries and replacing them promptly when the “low battery pump” alert is displayed. This precaution is crucial for ensuring continuous and reliable insulin delivery. It is important for patients to be prepared with spare batteries to…

Under-eye patches are a popular solution for treating concerns such as dark circles and puffiness by delivering active ingredients directly to the skin beneath the eyes. These gel or fabric-based treatments are infused with beneficial components like hyaluronic acid and collagen, offering hydration, firmness, and a refreshed appearance. Designed for all skin types, under-eye patches…

The 2024 presidential election is approaching, bringing potential changes to the U.S. healthcare system regardless of whether Kamala Harris or Donald Trump wins. During a recent webinar, experts discussed how a Harris presidency would focus on antitrust enforcement and healthcare fraud, while a Trump presidency would likely offer more regulatory flexibility. Harris is likely to…

HSE West and North West have 5 General Practitioner positions available, including one in Keadue, Co. Roscommon. The GMS Panel Size for this position is approximately 360. The closing date for applications is Monday, 4th November, 2024 at 4pm, with interviews scheduled for Wednesday 13th November, 2024. For more information and to apply, interested candidates…

A new study shows that a doctor’s empathy can significantly reduce a patient’s experience of pain. The research, published in the Proceedings of the National Academy of Sciences of the United States of America, used brain imaging to observe the impact of empathetic connections between chronic pain patients and clinicians. The study found that patients…