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AI model has potential to detect risk of childbirth-related PTSD

Researchers have developed an AI program that can identify signs of childbirth-related post-traumatic stress disorder (CB-PTSD) by analyzing short narratives from patients who have given birth. The program successfully identified a large number of participants likely to have CB-PTSD, indicating the potential for rapid and cost-effective screening for the disorder. Untreated CB-PTSD can have negative…

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Metrion Biosciences enhances High Throughput Screening services with access to Enamine compound libraries

Metrion Biosciences Limited and Enamine Ltd have partnered to enhance Metrion’s High Throughput Screening (HTS) services with access to Enamine’s compound libraries. Enamine’s collection is the largest globally, offering both CNS and ion channel-focused target libraries. These libraries can be split into screening sets for increased flexibility, efficiency, and cost-effectiveness in hit expansion and SAR…

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How Your ‘Sleep Style’ Can Determine Your Long-Term Health

Ryan Wong, a human resources manager, struggled with sleep until he prioritized improving his nighttime routine, leading to better rest. Penn State University research identified four “sleep types,” linking poor sleep to chronic conditions like diabetes and depression. Other studies found sleep issues in middle age can contribute to cognitive decline and brain health problems…

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High-Dose Valproate Linked to Significant Weight Gain

A study found that high-dose valproate is associated with weight gain in psychiatric patients, with the greatest gain reported in those taking ≥ 1300 mg/d. The study included 215 patients with various psychiatric diagnoses. Each 500-mg increase in valproate dose was associated with a weight increase of 0.52% per month over a year. Weight gain…

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Deputy Chief Medical Officer – Department of Health

The Department of Health aims to improve health and wellbeing in Ireland by providing the right care at the right time and place. The Chief Medical Officer offers expert advice on health and wellbeing, bioethics, and health policy development. The Deputy Chief Medical Officer supports these functions and must have registration on the Specialist Register…

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New York Digital Media Campaign Does Not Improve Duration of Untreated Psychosis

A digital media campaign in New York aimed to engage young individuals with early psychosis online, but did not result in significant improvements in treatment initiation or duration of untreated psychosis. The campaign targeted FEP programs and individuals with suspected CHR or psychotic disorders, with 371 individuals proceeding to remote clinical assessment. Despite efforts, there…

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Google Cloud partners with Bayer for AI applications for radiology

Google Cloud and Bayer are collaborating to develop AI applications to reduce radiologist burnout and improve diagnoses. Bayer will use Google Cloud’s technology, including generative AI tools, Vertex AI, BigQuery, Healthcare API, and Chronicle to expand its innovation platform. The aim is to help organizations create scalable and compliant AI-enabled software for medical imaging while…

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Studies show ChatGPT provides reliable information on vaccines, STIs

ChatGPT, a free AI system, has shown potential in healthcare, including providing accurate information on vaccines and STIs. Two studies presented at the ESCMID Global Congress found that ChatGPT could help reduce vaccine hesitancy and increase STI awareness. The system accurately responded to questions about vaccines and sexual health, performing at the level of professional…

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Drug shortages reached a record high as 2023 drew to a close

The U.S. is currently facing 323 ongoing drug shortages, the highest number since tracking began in 2001. These shortages are concerning due to the potential harm to patients. Basic and life-saving medicines like oxytocin, Rho(D) immune globulin, chemotherapy, pain/sedation medications, and ADHD pills are in short supply. The reasons for these shortages are varied and…

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Efficacy of a single low dose of esketamine after childbirth for mothers with symptoms of prenatal depression: randomised clinical trial

This study was a randomised, double blind, placebo controlled trial conducted in five hospitals in China to assess the effects of low dose esketamine on postpartum depression. Pregnant individuals with Edinburgh postnatal depression scale scores of ≥10 were enrolled and administered either esketamine or a placebo. The primary endpoint was the prevalence of major depressive…

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How to Get Your Child Involved

Parents understand that regular house cleaning helps prevent illnesses in children. Older children can start helping with chores, but parents should be honest and use logic rather than commands. Turning chores into a game can motivate younger children, but parents should avoid pitting siblings against each other. Rewards for helping with chores should be promised…

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Substantial Triglyceride Reduction With Plozasiran

Plozasiran, an investigational drug, significantly reduced triglyceride levels in patients at risk for pancreatitis. In the phase 2 SHASTA-2 study, most patients saw their levels fall below the pancreatitis risk threshold after receiving plozasiran injections. The drug’s safety profile was generally favorable, but it did lead to increased LDL cholesterol and a temporary decline in…

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Trials of Psychological Interventions for Depression Rarely Assess Suicidality

A systematic review and meta-analysis published in The Lancet Psychiatry found that clinical trials of psychological interventions for depression often do not assess suicidality, despite the known association between depression and suicide risk. Most trials did not include assessments for suicide, with only a small number reporting on suicidal thoughts and behaviors as adverse events….

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Attack of the Medicare Machines

In this episode of “An Arm and a Leg,” host Dan Weissmann explores the dark side of the American health care system, focusing on Medicare Advantage plans using an algorithm owned by UnitedHealth Group to make decisions about patient care. This algorithm has caused people to be prematurely discharged from nursing homes, leading to adverse…

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Medical cannabis use decreased in states where recreational use is legalized, study shows

Enrollment in medical cannabis programs increased by 33% from 2020 to 2022, but decreased in states where nonmedical adult use was legalized. The prevalence of medical cannabis use among U.S. citizens has increased significantly in the past decade. A study found that patient enrollment dropped dramatically in some states following the legalization of nonmedical adult-use…

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Vertex to buy Alpine Immune Sciences for $4.9 billion

Vertex Pharmaceuticals is acquiring Alpine Immune Sciences for $4.9 billion, marking its largest acquisition to date. The deal includes a promising drug called povetacicept, which is designed to treat IgA nephropathy (IgAN), a kidney autoimmune disorder affecting 130,000 people in the U.S. The drug will enter Phase 3 clinical development later this year. This acquisition…

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Research highlights STON2 variations involved in synaptic dysfunction and schizophrenia-like behaviors

The study focused on STON2 variations related to synaptic dysfunction and schizophrenia-like behaviors. The C-C (307Pro-851Ala) haplotype of STON2 was found to increase susceptibility to schizophrenia in the Chinese Han population. This variation leads to deficits in synaptic transmission, short-term plasticity, and schizophrenia-like behaviors in mice. Pharmacogenomic data showed that patients with this haplotype responded…

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Systematic reviews find inadequate evidence on the use of puberty blockers and hormones for gender distress

Two systematic reviews found that evidence on the use of puberty blockers and hormones for children and young people with gender-related distress is inadequate, leading to uncertainty about their effectiveness and impact on health. The studies showed limited quality and inconsistent evidence on key outcomes. Clinical guidelines are often not evidence-based, and the need for…

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Have Health Questions? Ask S.A.R.A.H., an AI Health Assistant

S.A.R.A.H. is an interactive artificial intelligence resource developed by the World Health Organization to provide information on health topics such as eating right, stress management, smoking cessation, mental health, and various diseases. S.A.R.A.H. is designed to be culturally sensitive and free of bias, speaking eight languages and providing personalized responses. The technology, powered by Open…

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Liquid Biopsy Shows Promise in Detecting Pancreatic Cancer

A new liquid biopsy assay combining a microRNA signature and a pancreatic cancer biomarker has shown 97% accuracy in detecting stage I/II pancreatic ductal adenocarcinoma. Developed by Ajay Goel and colleagues, the test was tested in Japan, China, South Korea, and the US, with promising results. Adding the biomarker carbohydrate antigen 19-9 increased accuracy to…

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Beta-blocker use after MI and preserved ejection fraction offers no benefit: REDUCE-AMI trial

A study called REDUCE-AMI found that using beta-blockers after a heart attack with preserved ejection fraction does not offer any benefits. This trial suggests that continuing to use beta-blockers in this specific situation may not be necessary. The study emphasizes the importance of personalized medicine and tailoring treatment plans to individual patients. The results of…

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Three Key Challenges for Healthcare CISOs

As hospitals face increasing cyberattacks, Chief Information Security Officers (CISOs) in healthcare must navigate challenges including keeping up with technological advancements, making impactful IT investments, and championing cybersecurity practices across the organization. Balancing innovation with security is crucial, as CISOs work to streamline processes, demonstrate the value of IT investments, and educate staff on security…

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The NIH Hopes To Make TMJ ‘Bearable.’ It Has a Long Way To Go.

The National Institutes of Health is increasing funding for research on TMJ disorders, which affect millions of Americans, mostly women. Despite its prevalence, TMJ remains under-researched and ineffective treatments are common. The NIH recently doubled annual funding for TMJ research and funded a new collaborative effort in 2023. The lack of proven treatments for TMJ…

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AI partners with liquid biopsy for ‘robust’ identification of women with ovarian cancer

Researchers presented results at the American Association for Cancer Research Annual Meeting showing that an artificial intelligence-driven algorithm using a liquid biopsy assay can differentiate women with ovarian cancer from healthy patients. The study found sensitivity rates ranging from 69% to 100% for different stages of ovarian cancer. The algorithm also had high specificity for…

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Study highlights impact of aldehydes on DNA damage and aging

A study by researchers at Nagoya University in Japan reveals that aldehydes are metabolic byproducts linked to premature aging, with implications for aging diseases and potential ways to combat aging by controlling exposure to aldehyde-inducing substances like alcohol, pollution, and smoke. Aldehydes damage DNA and proteins by forming DNA-protein crosslinks, leading to cellular processes malfunctioning…

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Congress likely to kick the can on covid-era telehealth policies

Rep. Brad Wenstrup urged federal lawmakers to continue telehealth payment changes past year-end deadline, highlighting benefits of virtual care. Congress faces decision on allowing telehealth services to remain accessible, impacting Medicare and private insurance plans. Telehealth surged during the pandemic, with Medicare and Medicaid enrollees using it the most. Lawmakers and policymakers are considering temporary…

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Expert Q&A With John Whyte, MD

Dr. John Whyte, WebMD’s chief medical officer, addresses access to health care issues for older adults, including cost, transportation, and quality of care. He emphasizes the importance of technology, such as sensors, trackers, and virtual reality tools, in managing health conditions. COVID-19 has shifted doctor-patient interactions towards virtual visits, highlighting the need for persistence when…

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New Tool Could Help Screen Patients for Zoom Dysmorphia

Zoom dysmorphia is a negative perception of one’s body image exacerbated by frequent video calls, causing anxiety, self-esteem issues, and a desire for cosmetic procedures. Dr. George Kroumpouzos and colleagues proposed a screening tool to identify zoom dysmorphia, as no diagnostic criteria exist. The tool includes open-ended questions and specific inquiries related to concerns about…

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How Can Healthcare Ensure Responsible AI Use?

Healthcare leaders worldwide are discussing the responsible integration of AI into clinical care, lacking a shared framework to govern its development and deployment. Collaboration among healthcare organizations is essential to establish guidelines for ethical AI use. Start with low-risk, high-reward use cases for generative AI models, such as nurse handoffs or medical research search tools….

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Cognitive Impairment in Treatment-Naive Patients With First Episode Psychosis

Individuals with first episode psychosis (FEP) exhibit cognitive impairment across all domains before receiving antipsychotic treatment, as shown in a systematic review and meta-analysis. This emphasizes the importance of identifying patients with severe cognitive challenges who may benefit from cognitive remediation. Cognitive deficits were observed in FEP patients compared to healthy controls, with the largest…

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