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First person to receive a genetically modified pig kidney transplant dies nearly 2 months later

Melissa Mattola-Kiatos, RN, nursing practice specialist, removes the pig kidney from its box to prepare for transplantation at Massachusetts General Hospital, March 16, 2024, in Boston. Richard “Rick” Slayman, the first recipient of a genetically modified pig kidney transplant, has died nearly two months after he underwent the procedure, his family and the hospital that…

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The Challenges of Parenting a Child With Eczema

A loving mother wants, above all else, good health for her child. Imagine, then, the emotional impact of discovering that your baby has eczema, of wishing more than anything to take away the itching and irritation. And imagine the worry when a woman with eczema becomes pregnant. The what-ifs are huge. Fortunately, there is excellent…

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How the brain is flexible enough for a complex world, without being thrown into chaos

Delineating pure, linear mixed, and nonlinear mixed selectivity using a context-dependent task. Credit: Neuron (2024). DOI: 10.1016/j.neuron.2024.04.017 Every day our brains strive to optimize a tradeoff: With lots of things happening around us even as we also harbor many internal drives and memories, somehow our thoughts must be flexible yet focused enough to guide everything…

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Smoking, dupilumab, life expectancy, more

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How herpes hijacks a ride into cells

Herpes simplex virus. Credit: CDC Northwestern Medicine scientists have discovered how herpes viruses hijack cellular transport processes to infiltrate the nervous system, as described in a study published in the Proceedings of the National Academy of Sciences. It’s estimated that 3.7 billion people globally are infected by herpes simplex virus type 1 (HSV-1), the main…

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Can pickleball, tennis and other racket sports really help you live longer?

Research suggests that picking up a racquet might be among the best decisions a person can make for their health. Credit: Matthew Modoono/Northeastern University Racket sports such as pickleball—often referred to as America’s fastest-growing sport—are clearly having a moment. New pickleball partnerships, leagues and playing courts are springing up everywhere. And on top of that,…

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Race and sex play a role, study finds

Credit: Pixabay/CC0 Public Domain Melanoma, an aggressive form of skin cancer that accounts for 75% of all skin-cancer-related deaths, is often detected later in people with darker skin complexions—and the consequences can be devastating, a Mayo Clinic study reveals. While melanoma may be found less frequently in people with darker complexions than fair ones, this…

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EU researchers are taking fresh approaches to understanding immune-system disorders for more effective treatments

Credit: Lisa Fotios from Pexels In mid-2015 and early 2016 in Finland, a group of scientists became interested in inspecting doormats. The pursuit, while seemingly unusual, had a serious aim: to determine whether a higher mix of microbes typically found in rural environments might protect against the development of type 1 diabetes, an immune-system disorder….

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Researchers show impact of insomnia and depression on asthma control

Credit: Unsplash/CC0 Public Domain Researchers at National Jewish Health have shown that underlying mood and sleep disorders negatively impact asthma control. Data reveal a considerable interaction between insomnia, depression and obstructive sleep apnea in people with asthma. The study was published in the Journal of Asthma. “Asthma control, sleep quality and mood are all critical…

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How incentives could better treat stimulant use disorder

Credit: Unsplash/CC0 Public Domain Are gift cards and cash one way to help ease the drug overdose crisis? The number of overdose deaths in the United States has doubled since 2015, exceeding 106,000 deaths in 2023. Although the overdose crisis is commonly referred to as the “opioid” overdose crisis, by 2021 approximately 50% of overdose-death…

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How long is long enough?

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New vaccine could protect against coronaviruses that haven’t even emerged yet

Comparison of immunization with Mosaic or Quartet Nanocages. Credit: Nature Nanotechnology (2024). DOI: 10.1038/s41565-024-01655-9 The rapid development of vaccines that protect against COVID was a remarkable scientific achievement that saved millions of lives. The vaccines have demonstrated substantial success in reducing death and serious illness after COVID infection. Despite this success, the effects of the…

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Scripps Research professor emeritus John Johnson selected as member of the National Academy of Sciences

Scripps Research professor emeritus John Johnson, PhD, has been elected to the National Academy of Sciences—one of the highest honors given to scientists. According to the Academy, members are selected “in recognition of their distinguished and continuing achievements in original research.” John Johnson, PhD. Image Credit: Scripps Research “Becoming a member of the Academy is a…

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Partner talks in their sleep? Here’s how to slumber soundly

Credit: CC0 Public Domain Parasomnia—it’s a blanket term for pesky behaviors that wreak havoc on your sleep. A third of U.S. adults get less than the recommended amount of shut-eye, a nationwide struggle linked to chronic diseases ranging from depression to Type 2 diabetes. Some parasomnias, however, don’t affect just the sleeper; they can affect…

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Early feasibility studies on climate-friendly albuterol inhaler completed

DevPro Biopharma and Bespak have announced the completion of early feasibility studies on DP007, a new formulation of albuterol in a pressurized metered dose inhaler (pMDI) which shows comparable performance to Ventolin® HFA but with a significant reduction in greenhouse gas emissions. This breakthrough pMDI is being developed by DevPro Biopharma, a respiratory-focused clinical development…

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Bolstering global mental health by prioritizing prevention

Credit: Pixabay/CC0 Public Domain Pamela Collins’ journey to global mental health started on a bus in Haiti in 1987. Working for the first time in a predominantly Black country, the young medical student sometimes took public transportation and enjoyed blending into the majority. “What really struck me that summer was how important social context is…

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Study links organization of neurotypical brains to genes involved in autism and schizophrenia

Three patterns of gene expression each align with distinct features of known neurobiology: C1 aligns with functional connectivity strength, C2 with brain oscillations in the theta-band range, and C3 with adolescent brain plasticity. Below, we show heatmaps (corrected for multiple comparisons) of the convergent associations between the three patterns C1-C3 and three mental health conditions…

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New partnership addresses key challenges for regulating digital mental health technologies

An MHRA and NICE partnership, funded by Wellcome, is addressing key challenges for regulating and evaluating digital mental health technologies (DMHTs) with input from patients, the public and mental health professionals.​ The long-term objective of this three-year project, which began in 2023, is to formulate guidance and other sources of information for developers, healthcare professionals,…

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NHS still faces waiting list challenges

Commenting on the publication today of the NHS monthly performance statistics, Tim Gardner, Assistant Director of Policy at the Health Foundation, said:  ‘While the pressure of winter has eased, today’s data shows urgent and emergency care is still feeling the strain. Over 42,000 patients spent more than 12 hours in A&E before being admitted to a…

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Kids and Anti-Obesity Meds: Real-World Challenges

DENVER — The ability to provide adolescents with highly effective anti-obesity medications that now carry approvals from the US Food and Drug Administration (FDA) and support in guidelines offers reassurance of their use; however, a reality check often awaits for clinicians in terms of challenges ranging from accessing and affording the medications to managing real…

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Salt Meter Could Improve Compliance With Low-Sodium Diet

Using a salt meter or sensor in food itself, in conjunction with other measures, can help reduce sodium intake by improving control of arterial hypertension at the community level, according to a Thai study. The results were described at the World Congress of Nephrology. “It is very important for people to reduce salt intake,” Surasak…

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Commentary: It’s in your DNA

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bDMARDs Prevent ESRD in Most Patients With AA Amyloidosis

TOPLINE: Treatment with biologic disease-modifying antirheumatic drugs (bDMARDs), particularly tocilizumab, can suppress inflammation and preserve renal function in a majority of patients with chronic inflammatory disorders who develop serum amyloid alpha (SAA) amyloidosis. METHODOLOGY: AA amyloidosis, characterized by the misfolding of the SAA protein, is observed in patients with inflammatory diseases and can lead to…

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