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Consultant Physician – General Medicine and Gastroenterology

The Southern Health and Social Care Trust is seeking to recruit a Consultant Physician Gastroenterologist to join the team at Craigavon Area Hospital. The role includes providing inpatient care, outpatient services, and endoscopy services across various hospital settings within the Trust. The successful candidate should have a Subspecialty interest in areas such as ERCP, IBD,…

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Repurposing BCG for Bladder Cancer: How the TB Vaccine Changed the Face of Cancer Treatments

Bacillus Calmette-Guerin (BCG) is a live attenuated vaccine historically used to prevent tuberculosis, but it has been repurposed as an immunotherapy to treat bladder cancer. The vaccine works by stimulating the immune system to recognize and destroy tuberculosis bacteria, and it has been found to have indirect anti-cancer properties. BCG is delivered directly into the…

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State of digital health investment, part 5: HTC Vive

HTC Vive is making strides in healthcare by developing virtual reality headsets and investing in medical extended reality (XR) technologies and companies. They have been active in the healthcare space since 2016, working on training simulation, 3D visualization, and therapeutics. Unlike other companies, HTC Vive prioritizes data privacy and security, having specific certifications for handling…

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Cal/BDP cream preferred over foam formulation among patients with psoriasis

A study compared the satisfaction of patients with psoriasis using Cal/BDP combination cream vs. foam. The cream formulation had higher satisfaction ratings among patients, suggesting it may increase adherence to treatment. Patients preferred the cream over foam for factors such as skin shininess, stickiness, ease of application, moisturization, and overall satisfaction. Although not statistically significant,…

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Trump, Vance, and Harris on mifepristone

The D.C. Diagnosis newsletter discusses Trump’s vague stance on the abortion pill mifepristone, Democrats preparing to reveal Medicare-negotiated drug prices, FDA rejecting MDMA for PTSD treatment, regulators considering new alcohol labels, and a new advocacy group challenging food corporations. The newsletter also highlights a complaint in Texas regarding delayed care due to abortion laws endangering…

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Mayo Clinic pioneers use of pulsed field ablation to treat atrial fibrillation

Mayo Clinic’s Heart Rhythm Clinic is utilizing pulsed field ablation (PFA) to treat atrial fibrillation (AFib), a common heart arrhythmia that can lead to serious complications like stroke. Unlike traditional ablative therapies, PFA uses high-energy bursts to target heart tissue causing AFib, reducing the risk of injury to nearby structures. FDA-approved PFA technology has been…

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Best Glucosamine Sulfate Supplements Of 2024 And Its Benefits

Over 2 million people in the US suffer from osteoarthritis (OA), a common degenerative joint disease affecting weight-bearing joints. Glucosamine sulfate, a natural sugar found in cartilage, is used to manage OA, often in combination with chondroitin. Studies show glucosamine may provide pain relief and support cartilage health by maintaining glycosaminoglycans. Side effects are mild,…

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To Advance Health Equity, We Must Stop Shaming Fax

The healthcare industry is moving towards accelerating data interoperability, with a common goal to “ax the fax.” While many healthcare stakeholders see fax as a barrier to seamless information exchange, it is essential for healthcare organizations like post-acute care facilities and substance use disorder clinics that don’t have access to electronic health records (EHRs). The…

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Aevice Health cementing Japan, Singapore expansion with $7M seed

Singapore-based startup Aevice Health has raised $7 million in an extended seed funding round led by Coronet Ventures, with participation from existing investors and SEEDS Capital. A spinoff from Nanyang Technological University, the company offers a smart wearable stethoscope, AeviceMD, for managing chronic respiratory conditions. The funding will be used for expansion in key markets…

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‘Aggressive’ treatment of GERD improves survival in systemic sclerosis with ILD

Proton pump inhibitors with histamine 2 receptor antagonists have been shown to reduce all-cause mortality in patients with systemic sclerosis and interstitial lung disease. Combination therapy was found to be more effective than single-agent treatment in improving survival. A study conducted by Alannah Quinlivan and colleagues analyzed data from the Australian Scleroderma Cohort Study, including…

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When $5 aspirin is as good as a $300 injection

Researchers were excited to find that aspirin was just as effective as a more expensive injectable blood thinner in preventing life-threatening blood clots after surgery. However, the adoption of aspirin by doctors and hospitals has been slow, with many sticking to hospital policies, habits, and preferences instead of following the latest evidence. The study involved…

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Brain biomarker in blood sample predicts stroke, researchers demonstrate

Researchers at Uppsala University have developed a simple blood test that can predict which individuals with atrial fibrillation are at higher risk of suffering a stroke. By analyzing the protein neurofilament in blood samples, the researchers found that individuals with higher neurofilament levels had a greater risk of experiencing a stroke. Combining neurofilament with standard…

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AlphaFold accelerates discovery of potential antipsychotic drugs by outperforming traditional methods

A study published in Science Advances conducted virtual screens to identify potential TAAR1 agonists for neuropsychiatric conditions using AlphaFold and homology modeling techniques. AlphaFold models outperformed homology models in virtual screening, leading to the discovery of potent TAAR1 agonists. Compound 65 showed high potency, selectivity, and favorable pharmacokinetic properties. However, AlphaFold struggled with larger synthetic…

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Know All About First FDA Approved Nasal Spray To Treat Severe Allergic Reactions

The FDA approved the first epinephrine nasal spray, Neffy, for the emergency treatment of allergic reactions, including anaphylaxis. This needle-free alternative can be used in children and adults weighing at least 66 pounds. Anaphylaxis is a life-threatening allergic reaction that requires immediate medical attention. Neffy provides a simpler alternative to traditional epinephrine injections, with comparable…

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Ascendis Pharma Lands Long-Awaited FDA Drug Approval in Rare Hormone Deficiency

Ascendis Pharma has received FDA approval for its hypoparathyroidism therapy, Yorvipath, providing an alternative to the Takeda Pharmaceutical drug Natpara that is set to be discontinued. Yorvipath aims to bring parathyroid hormone levels within the normal range, addressing the deficiency that causes issues with calcium and phosphate regulation in the body. The drug, a once-daily…

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Exercise Is Key for Parkinson’s Relief. But Bias, Underdiagnosis Hold Black Patients Back.

Organizers of a large exercise program for Parkinson’s disease realized that most participants were white, leading to efforts to diversify through hiring instructors who speak Spanish or Mandarin. However, recruiting Black participants remains a challenge due to lack of awareness about the disease and potential bias in diagnosis. Exercise is vital for Parkinson’s treatment, with…

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STAT+: Pharmalittle: We’re reading about FDA rejecting MDMA; a nasal spray for allergic reactions, and more

The FDA rejected MDMA as a treatment for PTSD, despite positive Phase 3 trial results, due to concerns about missing adverse event data and research bias. The agency requested another trial from Lykos Therapeutics to further study safety and efficacy. In a related development, the journal Psychopharmacology retracted three papers about MDMA-assisted psychotherapy. Many authors…

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US approves first nasal spray for anaphylaxis

The FDA has approved Neffy, the first adrenaline nasal spray for treating allergic reactions in adults and children over 30 kg. It is a single dose administered into one nostril. Neffy offers a non-invasive alternative to traditional adrenaline injections for emergency situations, including life-threatening reactions. Source link

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FDA OKs New Drug for Treating Hypoparathyroidism

The FDA has approved a new drug called palopegteriparatide (Yorvipath) for the treatment of hypoparathyroidism in adults. This condition occurs when there are insufficient levels of parathyroid hormone, leading to complications such as neuromuscular irritability and kidney issues. The drug is designed to provide stable PTH levels over a 24-hour period, unlike traditional treatments that…

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Beacon Hospital Autumn GP Study Morning

Beacon Hospital will host an Autumn GP Study Morning on September 28 at UCD’s O’Reilly Hall. The event starts at 8:30 am and will be available for in-person attendance or online streaming. Participants can earn 6 CPD points/1 Day GMS Study Leave. Registration is now open on the GP section of BeaconHospital.ie. Source link

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A statutory public inquiry is not always the most effective vehicle for learning lessons in the NHS

The article discusses the statutory public inquiry chaired by Kathryn Thirlwall into the murder and attempted murder of babies by former neonatal nurse Lucy Letby at the Countess of Chester Hospital Foundation Trust. It highlights the common themes in NHS inquiries, where concerns raised by staff are ignored, leading to inquiries years later. The article…

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How can we address the nexus of climate change, migration and infectious diseases?

A recent study explores the connection between climate change, migration, and infectious diseases, highlighting the impact of these interrelated issues on global health and vulnerability. High-income countries contribute more to global emissions but have lower infectious disease burdens, while low- and middle-income countries in Africa and Asia face the greatest burden and vulnerability. The study…

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Study reveals high undiagnosed rates of mild cognitive impairment in rural West Michigan

Corewell Health and Michigan State University researchers conducted a study using de-identified electronic health records of 1.5 million patients in West Michigan to analyze mild cognitive impairment (MCI) incidence rates and risk factors. Results indicated potential underdiagnosis of MCI in rural areas. The study also found a significant number of patients who went directly from…

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Organ Damage More Common in Early Stages of Lupus

A study on systemic lupus erythematosus (SLE) found that the first year after diagnosis is crucial, with 20% of patients experiencing new organ damage. Cardiovascular issues were the second most common form of damage after musculoskeletal issues in both early and later stages of SLE. The research, involving 4219 SLE patients, highlighted the importance of…

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MiRus receives FDA breakthrough device designation for posterior cervical spine system

MiRus has received FDA breakthrough device designation for its Europa posterior cervical system, designed for patients undergoing cervical and upper thoracic spinal fusion. The system features a smaller-diameter alloy rod for minimally invasive surgery. This designation is aimed at reducing the rates of spine implant failures and revision surgeries. Jordan Bauman, vice president of quality…

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MDMA papers retracted over data

The journal Psychopharmacology retracted three papers on MDMA-assisted psychotherapy due to ethical violations, including a case of sexual assault by an unlicensed therapist. Authors affiliated with MAPS and Lykos Therapeutics did not disclose these violations. The FDA rejected the treatment for PTSD, citing concerns about data integrity. Lykos disputes the retraction and has filed a…

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Brain circuits connecting stress to gut bacteria reveal new pathways for immune regulation

A recent study published in Cell revealed that stress-sensitive neural circuits can alter the gut microbiome by influencing duodenal glands. The study showed that the brain’s impact on mucosal secretion plays a key role in regulating the gut microbiome, particularly by promoting the growth of beneficial bacteria like Lactobacilli. The researchers found that stress-induced changes…

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Gut Flora Predicts Postoperative Crohn’s Disease Recurrence

A study published in Clinical Gastroenterology and Hepatology found distinct microbial signatures in mucosa-associated microbiota from ileal and colonic specimens that predict Crohn’s disease recurrence after surgery. Researchers analyzed biopsy samples from 262 patients with Crohn’s disease, finding lower diversity and specific microbial changes in patients who developed recurrence. By including microbiome data, the prediction…

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