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Blockbuster Sanofi & Regeneron Drug Dupixent Notches FDA Nod for an Inflammatory Skin Disease

Frank Vinluan , 2025-04-20 18:05:00 Sanofi and Regeneron Pharmaceuticals drug Dupixent has won FDA approval for chronic spontaneous urticaria, introducing a new approach to the treatment of this inflammatory skin disorder. It’s the seventh FDA approved indication for the blockbuster product. The regulatory decision announced Friday covers the treatment of patients age 12 and older…

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The lasting impact of paternal depression on children

, 2025-04-20 17:49:00 In popular culture, dads are stoic, sensitive and strong. So powerful is the mystique of the happy dad that celebrities, joke books – even hard seltzers – carry the label. Real life is different. Fathers get down, sometimes debilitatingly. And as new research from Rutgers Health reveals, when paternal depression goes undiagnosed…

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GOT2 as a metabolic and immunologic target in pancreatic cancer

, 2025-04-20 17:32:00 A new wave of scientific interest is spotlighting GOT2—glutamic-oxaloacetic transaminase 2—as a compelling therapeutic target in the fight against pancreatic cancer, one of the most lethal and treatment-resistant malignancies. This mitochondrial enzyme, deeply embedded in glutamine metabolism, plays a central role in sustaining cancer cell survival and growth. By regulating the malate-aspartate…

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Exploring citrullination as a key regulator of gene expression and disease

, 2025-04-20 17:07:00 Citrullination, a transformative protein post-translational modification, is gaining recognition for its wide-ranging impact on cellular function and human disease. This process, driven by the enzyme family known as peptidyl arginine deiminases (PADs), converts the amino acid arginine into citrulline, neutralizing its charge and fundamentally altering protein structure and behavior. Among its most…

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Redefining cardiovascular medicine through the lens of sncRNAs

, 2025-04-20 16:57:00 In a transformative review, small noncoding RNAs (sncRNAs) have emerged as pivotal regulators in the complex landscape of cardiovascular diseases. These RNA molecules, which do not encode proteins, were long overshadowed by their well-studied counterparts such as microRNAs. However, new insights highlight the substantial biological impact of lesser-known sncRNA subclasses including transfer…

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How Are Hospitals Bracing for Tariffs?

Katie Adams , 2025-04-20 13:44:00 The healthcare industry has faced a flurry of sweeping changes at the federal level since President Donald Trump took office. In recent months, healthcare leaders have scrambled to come up with strategies to address proposed Medicaid cuts, slashed research funding and the dismantling of the country’s public health infrastructure. Now,…

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Drug-Gene Testing: Key to Safer Cancer Treatment

Houda Hachad , 2025-04-20 13:47:00 Genomic medicine leverages an individual’s genetic information to guide healthcare decisions, with drug-gene testing (also known as pharmacogenomics, or PGx) being a key application that personalizes medication needs based on genetics. Although PGx testing offers a more precise, personalized approach to prescribing medications more safely and effectively, benefiting both patients…

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Women’s Health is Having Its Moment – It’s Time for the System to Catch Up

Barbara Levy , 2025-04-20 13:50:00 Women’s health has been historically sidelined – underfunded, underresearched and often misunderstood. While interest and investment around complex women’s health have increased, we’re still a long way away from delivering meaningful outcomes to women at scale.  Case in point: Endometriosis is a debilitating and life-limiting condition that impacts 1 in…

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Why UnitedHealth Group’s Shares Have Taken a Tumble

Marissa Plescia , 2025-04-20 13:13:00 UnitedHealth Group took quite the tumble on Thursday and Medicare Advantage troubles seem to largely be at fault. Its shares fell by over 22% after its first quarter earnings on Thursday. This is the Minnetonka, Minnesota-based company’s largest single-day drop since 1998. The healthcare giant also revised its adjusted earnings…

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Neuroscientists develop AI tool to unlock cerebellum’s secrets

, 2025-04-18 14:50:00 Graphical abstract. Credit: Cell (2025). DOI: 10.1016/j.cell.2025.01.041 Understanding and treating brain disorders such as tremor, imbalance, and speech impairments requires deep knowledge of the cerebellum, a part of the brain that’s crucial for making accurate movements. Scientists have long been able to eavesdrop on and record the electrical signals transmitted by neurons…

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Analysis reveals rise in claim denial rates for cancer-related advanced genetic testing

, 2025-04-18 15:00:00 Credit: Unsplash/CC0 Public Domain Both the use of next-generation sequencing (NGS) testing for cancer and the rate of claim denials for such testing increased between 2016 and 2021, despite implementation of a recent Medicare national coverage determination that established coverage standards for NGS testing. The analysis by Georgetown University researchers and colleagues…

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Common antiparasitic drug shows promise in halting growth of aggressive skin cancer

, 2025-04-18 15:55:00 Identifying areas of active gene regulation in IMR90 cells expressing MCPyV T antigens. Credit: Journal of Clinical Investigation (2025). DOI: 10.1172/JCI177724 A common pinworm medication may stop and reverse cancer growth in Merkel cell carcinoma, an aggressive form of skin cancer, according to research led by University of Arizona Cancer Center researchers…

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For advances in treating ACL injuries, look to dogs

, 2025-04-18 15:57:00 Credit: CC0 Public Domain Even after surgery, injuries to the anterior cruciate ligament (ACL) often lead to chronic pain and reduced mobility, with limited options for treatment. New research suggests that advances in knowledge and therapeutics may come from an unlikely source: dogs. In a study published April 18 in the Journal…

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Colder temperatures increase gastroenteritis risk in Rohingya refugee camps, study shows

, 2025-04-18 16:18:00 Kutupalong refugee camp in Cox’s Bazar, Bangladesh. (Photo: Takuya Takata). Credit: Takuya Takata A new study by scientists at Hokkaido University has found that lower temperatures significantly increase the risk of gastroenteritis among Rohingya refugees living in Bangladesh’s Kutupalong and Nayapara camps. Gastroenteritis is a viral or bacterial infection that causes inflammation…

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Global telemedicine therapy for dementia shows benefit in clinical trial

, 2025-04-18 16:19:00 Credit: Tima Miroshnichenko from Pexels For people living with primary progressive aphasia (PPA), a rare, early-onset neurodegenerative dementia that predominantly affects language abilities, something as simple as ordering their favorite meal at a drive-thru can be a deeply meaningful marker of independence. Led by experts at the University of Chicago’s Healthy Aging…

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AI analyzes chest radiographs to quickly shortlist potential matches in forensic cases

, 2025-04-18 16:22:00 Doctoral student Alexis VanBaarle, left, and Dr. Carolyn Isaac, right, discuss chest radiographs. Credit: Michigan State University An interdisciplinary team comprising faculty and doctoral students from the Department of Anthropology and Computer Science and Engineering has found a way to use artificial intelligence (AI) to help forensic anthropologists identify individuals faster and…

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How much protein do I really need?

, 2025-04-18 16:25:00 Every week it seems there’s a new diet or protein-enriched snack to try. UVA nutritionist Melanie Brede offers tips to make sure you meet your nutritional needs. Credit: John DiJulio, University Communications New protein-enriched products are hitting grocery store shelves and being advertised seemingly every day, while diets prioritizing protein make the…

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Study finds women much more likely to be aware of and have good understanding of obesity drugs

, 2025-04-18 16:26:00 Credit: Unsplash/CC0 Public Domain New research being presented at this year’s European Congress on Obesity (ECO 2025, Malaga, Spain, 11–14 May) shows that women are much more aware of and knowledgeable about the obesity drugs GLP-1/GIP receptor agonists (that include semaglutide and tirzepatide). The study is by Nadja Auerbach, Voy, London, UK,…

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Study finds potential link between infant acid-suppressants and celiac disease

, 2025-04-19 13:50:00 Credit: Unsplash/CC0 Public Domain Tel Aviv University-led research has found that infants prescribed acid-suppressive medications during their first six months of life had an increased risk of developing celiac disease autoimmunity under certain study conditions. Associations were present in a cohort study of more than 79,000 children, yet did not appear in…

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Avacopan Safety Described in Pooled Vasculitis Trial Data

, 2025-04-18 07:46:00 TOPLINE: Avacopan treatment for antineutrophil cytoplasmic antibody–associated vasculitis demonstrated lower rates of adverse events, serious adverse events, white blood cell (WBC) count reductions, and infections than standard treatment without avacopan. METHODOLOGY: Researchers pooled data from two phase 2 trials (CLEAR and CLASSIC) and one phase 3 trial (ADVOCATE) that compared avacopan with…

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VR and AR simulations help users practice stress management in realistic scenarios

, 2025-04-19 09:26:00 Anna Fang, a graduate student in the School of Computer Science’s Human-Computer Interaction Institute at Carnegie Mellon, uses a VR headset to practice stress relief strategies. Credit: Carnegie Mellon University Everyday situations can sometimes feel like big stressors, whether it’s delivering an important work presentation, attending a party full of strangers or…

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Racism in Healthcare: Is Finland Truly Egalitarian?

, 2025-04-18 09:02:00 Is racism a problem in Finnish healthcare? Finland tends to portray an image of egalitarianism, but there are indications it could be falling short in terms of providing equal healthcare to immigrants and people of color, and even when it comes to the experiences of healthcare professionals in the workplace. A report…

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Visual cortex tunes perception to match current objectives

, 2025-04-19 09:29:00 Early visual areas in the brain adapt their representations of the same visual stimulus depending on what task we’re trying to perform. Credit: Rungratsameetaweemana lab/Columbia Engineering When you see a bag of carrots at the grocery store, does your mind go to potatoes and parsnips or buffalo wings and celery? It depends,…

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What’s Really Behind Those Symptoms

, 2025-04-18 09:10:00 “Defined about 30 years ago, autoimmune pancreatitis [AIP] remains a diagnostic challenge,” said Vinciane Rebours, MD, PhD, professor and head of the Pancreatology and Digestive Oncology Department, Beaujon Hospital in Clichy, France. She spoke at the Francophone Days of Hepatology, Gastroenterology, and Digestive Oncology 2025, held in Paris. The challenge lies in the…

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Human Tissue On-Demand: How 3D Bioprinting Works

, 2025-04-18 10:04:00 We’ve come a long way from the Vacanti mouse. Back in the mid-90s, Charles Vacanti and other researchers experimented with cartilage regeneration and, with the help of a biodegradable mold and bovine cells, grew cartilage the size and shape of a human ear under the skin of a nude mouse, making it…

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Opioid control laws linked to 10% drop in domestic violence cases

, 2025-04-19 09:31:00 Credit: Unsplash/CC0 Public Domain A new study led by the University of South Florida reveals opioid control policies may offer broader public health benefits, including reducing instances of domestic violence. As policymakers continue to grapple with the opioid epidemic, this study highlights the power of research to inform effective public policy. The…

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The Good, the Bad, and the Risky: New Insights on STIs

, 2025-04-18 10:07:00 At European Society of Clinical Microbiology and Infectious Diseases Global 2025, held recently in Vienna, Austria, one of the oral sessions focused on key updates regarding sexually transmitted infections (STIs). Among the presentations, two stood out due to their clinical relevance. The first, titled “Post-Exposure Prophylaxis with Doxycycline (doxy-PEP): Uses and Results…

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Science-backed exercise therapy improves low back pain

, 2025-04-18 16:29:00 Credit: Pixabay/CC0 Public Domain Research supports the effectiveness of a kinesiology-based method to treat lower back pain, say study authors working in collaboration with the National Research Council of Italy, and scientists at the Sbarro Health Research Organization under the leadership of its Founder and President, Antonio Giordano, M.D., Ph.D., Professor at…

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Patient survey reveals cautious support for AI in mammography screening

, 2025-04-18 17:52:00 The results of a large survey from a diverse patient population revealed cautious support for artificial intelligence (AI) implementation in screening mammography, according to a study published today in Radiology: Imaging Cancer, a journal of the Radiological Society of North America (RSNA). Personal medical history and sociodemographic factors influenced respondent’s level of…

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Study Reveals Racial Disparities in IBD Healthcare

, 2025-04-18 11:07:00 TOPLINE: Among individuals with inflammatory bowel disease (IBD), Asian and Hispanic American individuals had lower healthcare utilization than White American individuals, whereas Black American adults aged 65 years or older had higher use of emergency department utilization. METHODOLOGY: Although IBD is more common among White American individuals, Black and Hispanic individuals face…

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Using AI to understand how the brain processes language during real-life conversations

, 2025-04-19 03:04:00 What were you investigating? We investigated how our brains process language during real-life conversations. Specifically, we wanted to understand which brain regions become active when we’re speaking and listening, and how these patterns relate to the specific words and context of the conversation. What methods did you use? We employed artificial intelligence…

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Can a Polygenic Risk Score Help Catch More Prostate Cancers?

, 2025-04-18 11:41:00 Incorporating a polygenic risk score into prostate cancer screening could enhance the detection of clinically significant prostate cancer that conventional screening may miss, according to results of the BARCODE 1 clinical trial conducted in the United Kingdom. The study found that about 72% of participants with high polygenic risk scores were diagnosed…

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