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New Acne-Specific Lasers Are Not Identical

, 2025-04-21 12:20:00 ORLANDO, Florida — Two lasers developed specifically to target the sebaceous gland were cleared by the US Food and Drug Administration (FDA) for the treatment of acne vulgaris in 2022, but it is unclear whether there are meaningful clinical differences between them. The good news has been the relatively high rates of…

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Medicare Advantage CEO: My baby is ugly…(video)

Arundhati Parmar , 2025-04-21 16:34:00 Straight talk is what everyone wants but rarely gets. At the Medicarians conference held earlier this month in Las Vegas, I had the opportunity to engage Sachin Jain, CEO of SCAN Health Plan, in a fireside health chat to talk about the current state of Medicare. While he extolled the…

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Researchers uncover genetic link between autism spectrum disorder and myotonic dystrophy type 1

, 2025-04-21 14:09:00 Scientists from The Hospital for Sick Children (SickKids) and University of Las Vegas Nevada (UNLV) have uncovered a genetic link between autism spectrum disorder (ASD) and a rare genetic condition called myotonic dystrophy type 1 (DM1). The study, published today in Nature Neuroscience, suggests that while ASD has previously been characterized by…

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Dramatic Uptake of Tirzepatide Seen for T2D and Weight Loss

, 2025-04-21 14:05:00 New data documented dramatic shifts in prescribing for both type 2 diabetes (T2D) and weight loss, particularly with the uptake of tirzepatide (Lilly) and declines in the use of older agents. Between 2021 and 2023, prescriptions of tirzepatide, semaglutide (Novo Nordisk), and sodium-glucose cotransporter 2 (SGLT2) inhibitors for people with T2D increased…

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Clinician Adoption: How HealthTech Can Overcome Key Barriers

Yegor Tsynkevich , 2025-04-21 14:50:00 Healthcare innovation is frequently accompanied with skepticism and resistance, even when it promises to improve patient outcomes and operational efficiency. Healthtech companies prioritize clinical validation, regulatory approvals, and performance metrics to ensure their technology meets industry standards. However, they often overlook one crucial factor: clinician adoption. Even the most promising…

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Readout Newsletter: Immunovant, Roivant, Sanofi, Regeneron

Meghana Keshavan , 2025-04-21 13:36:00 Want to stay on top of the science and politics driving biotech today? Sign up to get our biotech newsletter in your inbox. Morning. Today, we talk lots about tariffs — how they might impact drugmakers, patients, and even Ireland. Also, Novo Nordisk challenges Medicare over drug differentiation, and more.  Tariffs threaten…

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Saliva test plus AI could flag chemotherapy risk, early study results suggest

, 2025-04-21 13:46:00 Virginia Tech researchers John Janiga, Dzenis Mahmutovic (seated), Katherine Brown, and lead investigator Carla Finkielstein work together in the Molecular Diagnostics Laboratory at the Fralin Biomedical Research Institute at VTC to develop a test that could help doctors identify cancer patients at risk for severe chemotherapy side effects. Credit: Clayton Metz/Virginia Tech…

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White House Announces Drug Policy Priorities

, 2025-04-21 12:22:00 A recently released statement on Trump administration’s drug policy priorities called for a focus on stopping illicit drugs from coming into the United States, prosecuting those responsible for overdose deaths, expanded access to naloxone, and new campaigns “to inform the American people of the dangers of illicit drug use, the hope of…

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NIH grants, Covid guidance, pharma tariffs

Jason Mast , 2025-04-21 13:05:00 Get your daily dose of health and medicine every weekday with STAT’s free newsletter Morning Rounds. Sign up here. Good morning, Jason Mast here filling in for Theresa. The Morning Rounds editor has informed me that she has tired of all this debate over potato chips and the curious case of…

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Merging autonomy with manual control for wheelchair users

, 2025-04-21 12:38:00 The CoNav autonomous wheelchair developed by U-M engineers gives users the option of taking control. Credit: Vineet Kamat, Carol Menassa Autonomous technologies promise passengers travel without concern—the ability to get from Point A to Point B without needing to be engaged in the process. Yet passengers still don’t trust computers the way…

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In Heart Failure, Cellular Therapy Is Active

, 2025-04-21 12:29:00 CHICAGO — For patients with advanced heart failure, an injection of autologous mononuclear cells into damaged myocardia missed the primary endpoint in the sham-controlled, randomized, blinded CardiAMP-HF trial, but there was a strong signal of benefit, supporting further assessment. The study had a hierarchical win-ratio design, and the intervention met two of…

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What Are Health Systems’ Strategic Priorities in 2025?

Stephanie Baum , 2025-04-21 11:30:00 The healthcare investor conference MedCity INVEST, scheduled for May 20-21 at the Willis Tower in Chicago, will spotlight strategic priorities for health systems at a time when many face uncertainty amidst dramatic changes at HHS and with government funding at risk. A panel discussion on the strategic priorities of health…

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Why Cameras Are Popping Up in Eldercare Facilities

Paula Span , 2025-04-21 09:00:00 Paula Span The assisted living facility in Edina, Minnesota, where Jean Peters and her siblings moved their mother in 2011, looked lovely. “But then you start uncovering things,” Peters said. Her mother, Jackie Hourigan, widowed and developing memory problems at 82, too often was still in bed when her children…

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Protein that stops cell division could serve as a biomarker or therapeutic target for liver disease

, 2025-04-21 11:14:00 Credit: The FASEB Journal (2025). DOI: 10.1096/fj.202402942R A protein that stops cells from dividing in response to damage or stress could be a new biomarker or therapeutic target for metabolic dysfunction-associated steatotic liver disease (MASLD), according to research published in The FASEB Journal. The protein, called cyclin-dependent kinase inhibitor 1A (CDKN1A), was…

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California halts medical parole, sends several critically ill patients back to prison

, 2025-04-21 10:46:00 California has halted a court-ordered medical parole program, opting instead to send its most incapacitated prisoners back to state lockups or release them early. The unilateral termination is drawing protests from attorneys representing prisoners and the author of the state’s medical parole legislation, who say it unnecessarily puts this vulnerable population at…

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Computer Prompts Stem Antibiotic Overuse, Study Finds

, 2025-04-21 10:26:00 Despite guidelines stating otherwise, clinicians continue to prescribe inappropriate antibiotics to hospitalized patients with skin and soft tissue infections (SSTIs), raising costs and increasing the risk for drug-resistant organisms. A new study has found that computer-assisted recommendations, coupled with targeted best practices, significantly reduce the use of extended-spectrum antibiotics, all without increasing…

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The Rare Surgery That Saved Their Lives

, 2025-04-21 09:32:00 Born twice? It sounds impossible, but that’s exactly the story of miracle baby Rafferty Isaac in the U.K. At just 20 weeks, he was temporarily removed while in the womb so doctors could perform life-saving surgery on his mother, who had been diagnosed with ovarian cancer. After the complex five-hour procedure, Rafferty…

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California Halts Medical Parole, Sends Several Critically Ill Patients Back to Prison

Don Thompson , 2025-04-21 09:00:00 SACRAMENTO, Calif. — California has halted a court-ordered medical parole program, opting instead to send its most incapacitated prisoners back to state lockups or release them early. The unilateral termination is drawing protests from attorneys representing prisoners and the author of the state’s medical parole legislation, who say it unnecessarily…

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Older adults respond well to immunotherapy despite age-related immune system differences, researchers find

, 2025-04-21 09:00:00 Credit: Unsplash/CC0 Public Domain Older adults with cancer respond just as well as younger patients to immune checkpoint inhibitors despite age-related immune system differences, according to a study by researchers from the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy, and the Johns Hopkins Convergence Institute. Most new…

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Best Insulin Resistance Index for Pediatric Obesity?

, 2025-04-21 09:04:00 TOPLINE: A recent study found that the homeostasis model assessment insulin resistance (HOMA-IR), quantitative insulin-sensitivity check index (QUICKI), and fasting glucose/insulin ratio (FGIR) were stronger predictors of insulin resistance than the triglyceride glucose index (TyG) in children with overweight or obesity. METHODOLOGY: Researchers conducted a single-center retrospective study to establish the correlation…

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Three ways for physicians to become better advocates

Hala Durrah , 2025-04-21 08:30:00 Democrats recently unveiled a campaign to recruit and elect 100 doctors to public office. Democrats hope that by recruiting physicians to public office, they will be able to combat misinformation and restore trust in medicine and science.  Amid a full-blown measles outbreak, the U.S. plan to withdraw from the World…

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Can Viral DNA Inform Outcomes in Nasopharyngeal Cancer?

, 2025-04-21 07:16:00 TOPLINE: In patients with nasopharyngeal carcinoma who received induction-concurrent (chemo)radiotherapy, persistent Epstein-Barr virus (EBV) DNA positivity or its resurgence during treatment was associated with worse survival outcomes, whereas rapid clearance of EBV DNA following induction chemotherapy was associated with better survival. METHODOLOGY: Plasma EBV DNA is the most widely used biomarker for…

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5 Long COVID Predictions for 2025 and Beyond

, 2025-04-21 06:30:00 The Centers for Disease Control and Prevention confirmed its first US case of COVID-19 in early 2020, and 8 months later the World Health Organization described a post-viral condition called long COVID. Since then, millions of Americans, around 8% of those with acute COVID, have also been identified as having long COVID….

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A horse therapy program in Namibia brings joy to children with learning disabilities

, 2025-04-21 06:21:00 Immanuel Hoxobeb assists Alicia who participates in the “Enabling Through the Horse,” therapy program outside Windhoek, Namibia, on Feb. 18, 2025. Credit: AP Photo/Dirk Heinrich Susan de Meyer’s horses have different effects on different children. Hyperactive kids learn to be a little quieter around them while nonverbal children are moved to communicate…

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Skin Diseases Among Top Global Causes of Disability

, 2025-04-21 05:33:00 TOPLINE: The Global Burden of Disease (GBD) Study 2021 reported 44.84 million disability-adjusted life years (DALYs) because of skin and subcutaneous diseases. METHODOLOGY: Researchers utilized data from the GBD Study 2021 to examine incidence, prevalence, and DALYs for 371 diseases and injuries across 204 countries and territories from 1990 to 2021. Skin…

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Is the 7/7 Hospitalist Shift Right for You?

, 2025-04-21 05:13:00 Right after residency, Maryland-based hospitalist Anisha Bassi, MD, took on a 7 days on/7 days off shift. She worked 12-hour days, and if she wanted to boost her income, she would add in an overnight, or a 4 AM to noon. It was tiring, she said, but she was young, and it…

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Tusi (a mixture of ketamine and other drugs) is on the rise among NYC nightclub attendees, study suggests

, 2025-04-21 04:10:00 Credit: Pixabay/CC0 Public Domain “Tusi,” also known as “tucibí” or “pink cocaine,” is a drug concoction that emerged in Latin America and Europe within the past decade and is becoming increasingly popular in the U.S. A study published in Addiction estimates that in 2024, 2.7% of electronic dance music nightclub-attending adults in…

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Dermatologists Recommend 23 Key Skincare Ingredients

, 2025-04-21 02:50:00 TOPLINE: A panel of dermatologists reached a consensus on 23 topical ingredients that they considered useful for seven common skin concerns, with retinoids recommended for five of those conditions. METHODOLOGY: A literature review (1990-2020) identified 318 discrete cosmetic ingredients, which were then evaluated by 17 expert dermatologists who were either program directors…

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Unmasking Nrf2 as a key driver of treatment resistance in osteosarcoma

, 2025-04-20 16:47:00 A deeper understanding of osteosarcoma, the most common primary malignant bone tumor affecting children and adolescents, is reshaping strategies for overcoming treatment resistance. Central to this breakthrough is Nuclear factor E2-related factor 2 (Nrf2), a transcription factor now recognized as a pivotal player in chemoradiotherapy resistance. Traditionally acknowledged for its role in…

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Lipid metabolism as a driver of therapy resistance in triple negative breast cancer

, 2025-04-20 17:04:00 Lipid metabolism has emerged as a central player in the progression and therapy resistance of breast cancer, particularly the aggressive subtype known as triple-negative breast cancer (TNBC). This review article highlights how disruptions in lipid regulation can significantly influence the behavior of breast cancer cells, impacting their growth, metastasis, and response to…

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Reversing adipose tissue fibrosis through targeted microRNA therapies

, 2025-04-20 17:19:00 A new review published in Genes & Diseases highlights the transformative role of microRNAs (miRNAs) in regulating and potentially reversing adipose tissue fibrosis, a condition closely linked to obesity, diabetes, and cardiovascular disease. Fibrosis, driven by abnormal extracellular matrix (ECM) accumulation, disrupts normal adipose tissue function and contributes to broader organ dysfunction….

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What to know if your child takes a blow to the head

, 2025-04-20 18:49:00 by Jeffrey Lo, MD, Attending Physician, Orthopedics and Sports Medicine Department, Boston Children’s Hospital When a child tumbles to the floor from a blow to the head, a parent’s inner alarms should sound. The child may have a brain injury. Here’s what parents need to know: What is a concussion? A concussion…

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Molecular drivers and emerging treatments in anaplastic thyroid cancer

, 2025-04-20 17:36:00 Anaplastic thyroid cancer (ATC), a rare yet highly aggressive malignancy, continues to represent a major clinical challenge. A recent review published in Genes & Diseases offers a comprehensive overview of the molecular mechanisms, diagnostic approaches, and therapeutic strategies driving current and future management of this lethal disease. ATC, accounting for a small…

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New therapeutic frontiers in the management of achondroplasia

, 2025-04-20 17:42:00 A recent publication in Genes & Diseases has delivered a compelling synthesis of the latest insights into the cellular mechanisms and therapeutic interventions for achondroplasia, the most common form of genetic dwarfism. This disorder stems primarily from gain-of-function mutations in the fibroblast growth factor receptor 3 (FGFR3) gene, which exerts widespread effects…

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