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NIH research grant restrictions, a ban on more food dyes

John Wilkerson , 2025-04-22 19:47:00 You’re reading the web edition of D.C. Diagnosis, STAT’s twice-weekly newsletter about the politics and policy of health and medicine. Sign up here to receive it in your inbox on Tuesdays and Thursdays. STAT won its first National Magazine Award for General Excellence. Not bad, huh? Help us keep up the good…

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Wording matters in parental support for adolescent medical services, study finds

, 2025-04-22 19:32:00 Credit: Unsplash/CC0 Public Domain A study by researchers from Emory University’s Rollins School of Public Health and Vanderbilt University Medical Center has found that parental support for adolescent medical consent varied significantly depending on how the question was framed. Tennessee’s Mature Minor Doctrine, which allowed for adolescent medical consent in some instances,…

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Obesity alters the rhythm of liver’s starvation response

, 2025-04-22 19:09:00 Researchers led by Keigo Morita and Shinya Kuroda of the University of Tokyo have revealed a temporal disruption in the metabolism of obese mice when adapting to starvation despite no significant structural disruptions in the molecular network. This is a breakthrough discovery as research including the temporal dimension in biology has been…

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Stop Smoking Now to Protect Your Vision, Experts Warn

, 2025-04-22 12:31:00 TOPLINE: Current smokers faced up to 12-fold higher risk for age-related macular degeneration, a threefold higher risk for primary open-angle glaucoma, and a fourfold higher risk for cataracts. The risk for certain ocular disorders persisted among individuals with a previous history of smoking. METHODOLOGY: Researchers searched PubMed, Scopus, and Web of Science…

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STAT Breakthrough West 2025: A behind-the-scenes look

Matthew Herper , 2025-04-22 18:12:00 A behind-the-scenes look at this year’s agenda Dear readers: You come to STAT for tough, smart journalism that helps you think about big topics like how AI will change medicine and the upheaval enveloping U.S. science. So join us in San Francisco on May 14, when we’ll do it live.  Those…

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Heavy Drinking Tied to Risk for Brain Lesions

, 2025-04-22 12:37:00 TOPLINE: Consuming at least eight alcoholic drinks per week was associated with a 133% higher risk for hyaline arteriosclerosis, a brain lesion associated with memory and thinking problems, than not drinking, new research showed. A history of heavy drinking was linked to an 89% higher risk for these lesions, as well as…

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Biolinq raises $100M for intradermal glucose sensor for type 2 diabetes

, 2025-04-22 15:26:00 Biolinq, a health technology company developing precision multi-analyte wearable biosensors for metabolic health, announced it secured $100 million in Series C funding.  Alpha Wave Ventures led the round with participation from existing investors AXA IM Alts, M Ventures, LifeSci Venture Partners, RiverVest Venture Partners, Hikma Ventures, Taisho Pharmaceutical, Features Capital and Aphelion…

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Predicting how an autistic child will develop cognitively

, 2025-04-22 15:42:00 Combining genetic variants and developmental milestones to predict intellectual disability (ID) in autistic individuals. Credit: JAMA Pediatrics (2025). DOI: 10.1001/jamapediatrics.2025.0205 Will a child who’s evaluated for autism later develop an intellectual disability? Can this be accurately predicted? Early-childhood experts in Quebec say they’ve have come up with a better way to find…

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Sex differences in substance use patterns among individuals with panic disorder

, 2025-04-22 11:57:00 In a comprehensive Genomic Press peer-reviewed research article, researchers have revealed compelling evidence that biological sex significantly influences substance use patterns among individuals with panic disorder, with implications for both clinical assessment and treatment strategies. The noteworthy study, published today in the journal Genomic Psychiatry, examined associations between panic disorder and both…

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TILs Plus Pembro Show Efficacy in GI Cancers

, 2025-04-22 12:44:00 Neoantigen-specific tumor-infiltrating lymphocytes (TILs) plus pembrolizumab demonstrate efficacy against treatment-refractory gastrointestinal (GI) cancers in early results from a phase 2 trial. This is the first clinical trial to show that TILs can deliver responses in patients with metastatic GI cancers, making it a notable advance in the efforts to adapt cellular immunotherapy…

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Mouse study links senescent cells to post-surgical delirium in elderly

, 2025-04-22 14:11:00 Clearing senescent cells reduces orthopedic surgery-induced brain inflammation in aged mice. Credit: Madhurakkat Perikamana et al. A study in mice suggests that senescent cells are at least partially responsible for post-surgical delirium and similar conditions in elderly people—and identifies a combination of drugs that might be able to prevent the complication. Elderly…

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New approach to treating chronic pain without opioids

, 2025-04-22 12:27:00 Chronic pain, a common and debilitating condition, often leads practitioners to prescribe opioids in escalating doses. The prescription of opioids has created a serious nationwide crisis that killed more than 107,000 Americans from December 2020 through December 2021, according to a report by the American Medical Association (“Nation’s opioid-related overdose and death…

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Peanut Challenge May Reveal No Need for OIT After All

, 2025-04-22 13:09:00 TOPLINE: Nearly 70% of children with low-risk peanut allergy tolerated a peanut oral food challenge, negating the need for allergy treatment, data from one center showed. METHODOLOGY: Researchers sought to determine how many children with a previously diagnosed low-risk peanut allergy could tolerate a full peanut oral food challenge during initial dose…

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Cancer death rates higher for children in neighborhoods with persistent poverty, study finds

, 2025-04-22 12:00:00 The risk for cancer death is higher among children diagnosed in neighborhoods marked by persistent poverty, according to a study published online April 21 in Pediatrics. Emma Hymel, M.P.H., from the University of Nebraska Medical Center in Omaha, and colleagues used Surveillance, Epidemiology, and End Results-22 Registries Incidence Data with Census Tract…

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Long-Term Cognitive Outcomes in Moderately Preterm Birth

, 2025-04-22 12:00:00 TOPLINE: Moderately preterm birth independently predicted lower cognitive scores in late childhood. METHODOLOGY: This cross-sectional study analysed how gestational age affects cognition in children aged 9-10 years by using polygenic scores to separate biological from environmental influences. The study population included 5946 children (mean age, 9.9 years; 51.8% boys) who were stratified…

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AI-driven ADHD screening using eye images developed in Korea

, 2025-04-22 10:22:00 A new study from South Korea has demonstrated the use of AI models to possibly diagnose and stratify attention deficit hyperactivity disorder by analysing eye images. FINDINGS Researchers from Yonsei University Health System have used four machine learning models and the AutoMorph deep learning pipeline to analyse approximately 1,108 retinal fundus photographs…

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Six reasons for employers to waive preventive care out-of-pocket costs

Jeff Levin-Scherz , 2025-04-22 08:30:00 On Tuesday, the Supreme Court heard oral arguments in Kennedy v. Braidwood Management, a case in which an employer is arguing that the formation of the U.S. Preventive Services Task Force (USPSTF) violates the Constitution’s appointments clause. The Affordable Care Act (ACA) regulations require that employer-sponsored health plans cover USPSTF-approved…

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Study highlights struggles of GPs in deprived neighborhoods

, 2025-04-22 10:35:00 Credit: MART PRODUCTION from Pexels English GPs in areas of socioeconomic deprivation endure increased job pressures related to managing complex patients, insufficient resources, and difficulty in finding locum cover, an analysis by University of Manchester researchers has shown. The researchers suggest that policymakers should increase funding so that deprivation is taken into…

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How to Make the Most of It

, 2025-04-22 09:56:00 The clinical training part of medical school means you finally get to put all the book learning, lectures, laboratories, and other preliminary lessons into practice. But it’s more than just the application of recently acquired knowledge. Rotations not only give you a chance to develop skills and care directly for patients but…

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New Ultrasound Protocols to Detect Atherosclerosis Early

, 2025-04-22 07:39:00 Clinical ultrasound is invaluable for detecting atherosclerosis. However, methods to assess vascular areas with atheromatous plaques and their extent remain inconsistent and lack standardisation. To address this, the Spanish Society of Internal Medicine and the Spanish Society of Hypertension and Vascular Risk published two protocols for vascular risk assessment: VAScular UltraSound (VASUS)…

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Mistrust in science and medicine

Leonard H. Calabrese, DO , 2025-04-21 13:41:00 April 21, 2025 2 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable…

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Basal cell carcinoma’s low immunogenicity linked to suppression of antigen presentation from its cell of origin

, 2025-04-22 06:55:00 Basal cell carcinoma has low immunogenicity. Tumor cells express Foxc1 protein (red), which suppresses HLA class I (green) in the tumor cells. Credit: Shawn Demehri, Massachusetts General Hospital Compromised antigen presentation ranks among the top mechanisms that render cancers non-immunogenic (non-responsive to immune-based therapies). Despite harboring the highest tumor mutational burden of…

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Psilocybin use surges across all age groups since 2019

, 2025-04-22 03:29:00 Use of psilocybin, the hallucinogenic chemical found in what is known as “magic mushrooms,” has increased significantly nationwide since 2019, according to a new study led by researchers at the University of Colorado Anschutz Medical Campus and Rocky Mountain Poison and Drug Safety. The study was published today in the Annals of…

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Pricey New Hemophilia A Drug Shows Limited Value

, 2025-04-22 06:32:00 TOPLINE: Prophylaxis with efanesoctocog alfa, while reducing annualized bleeding rate by 77% compared with standard-care factor VIII in severe hemophilia A, is not cost-effective at current US pricing, requiring a > 47% price reduction to meet cost-effectiveness thresholds. METHODOLOGY: A Markov cohort model was constructed using data from the XTEND-1 study, which…

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