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Sarilumab allows steroid taper ‘more frequently’ vs methotrexate in polymyalgia rheumatica

Patients with polymyalgia rheumatica were more likely to discontinue steroids after treatment with sarilumab compared to methotrexate, according to data presented at ACR Convergence 2024. A study analyzed commercial claims data from Komodo HealthMap and found that 59% of patients using sarilumab were able to discontinue glucocorticoids within 6 months, compared to 35% for methotrexate. Patients on sarilumab required fewer days on steroids and a lower cumulative dose compared to methotrexate. This study provides evidence that sarilumab is an effective steroid-sparing agent for patients with polymyalgia rheumatica, offering rheumatologists a new treatment option to consider.

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