Alex Young , 2025-04-28 14:24:00
April 28, 2025
1 min read
Key takeaways:
- Inflammation was not significantly different between the dropless regimen and topical regimen.
- Patients in the dropless group reported higher satisfaction.
LOS ANGELES — A dropless regimen for cataract surgery had similar inflammation rates as standard of care, according to a study presented at the American Society of Cataract and Refractive Surgery meeting.
“The purpose of this study was to determine if the administration of intracameral phenylephrine and ketorolac, or Omidria [Rayner], along with subconjunctival triamcinolone and intracameral moxifloxacin results in an equal or lower proportion of patients developing complications than those receiving the standard of care, which would be topical drops,” Cathleen M. McCabe, MD, said.
Image: Eamon N. Dreisbach
In the study, 188 eyes of 94 patients were randomly assigned to receive the dropless regimen or a topical regimen of ketorolac, prednisolone acetate and moxifloxacin drops. The primary endpoint was the proportion of eyes with inflammation on day 8. Key secondary endpoints included proportion of eyes experiencing complications and patient satisfaction.
In their comparison of dropless and topical regimens, McCabe and colleagues found no statistically significant difference in the proportion of eyes experiencing inflammation at any point, including at the primary endpoint of day 8 (8.9% vs. 7.7%, respectively).
Additionally, patient-graded pain was similar in both groups on day 1 and day 8.
McCabe said overall patient satisfaction was the area in which there was a preference for the dropless regimen.
“My patients who had the dropless regimen were just very, very happy with that eye,” she said. “They would tell you at every single visit how that was their better eye. Even if they weren’t really seeing better, they felt better about it and their experience. That score of 10 was a much tighter score than the 7 score in the topical regimen, just meaning patients had variable satisfaction rates. And it costs them more out of pocket as well for the topical regimen, as we would expect.”
Sources/Disclosures
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McCabe CM, et al. Cataract surgery complication rates: Preoperative NSAID, intracameral phenylephrine/ketorolac, and subconjunctival steroid vs. topical drops. Presented at: American Society of Cataract and Refractive Surgery meeting; April 25-28, 2025; Los Angeles.
Disclosures:
Healio could not confirm relevant financial disclosures at the time of publication.
