, 2025-04-30 12:00:00 TOPLINE: More than 90% of patients with inflammatory bowel disease (IBD) accepted the switch from the adalimumab reference product to adalimumab biosimilars, with favourable survival and remission outcomes and a positive patient experience at 12 months. A poor opinion of generic drugs was associated with the refusal to switch. METHODOLOGY: Researchers conducted…
, 2025-05-01 06:05:00 Who has not forgotten a name, occasionally misplaced things, or stumbled over the right word during a conversation? However, with growing awareness about dementia, these occasional memory lapses often leave people wondering if it could be an early sign of dementia. As people get older, you might notice that it takes a…
Justin Cooper , 2025-04-30 14:58:00 April 30, 2025 3 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process…
Katie Palmer , 2025-04-30 08:30:00 Katie Palmer covers telehealth, clinical artificial intelligence, and the health data economy — with an emphasis on the impacts of digital health care for patients, providers, and businesses. You can reach Katie on Signal at palmer.01. It’s been a year since the federal government clarified that technology tools used in…
, 2025-04-30 20:49:00 Credit: CC0 Public Domain Sodium-glucose cotransporter-2 inhibitors (SGLT2i), or gliflozins, are medications used in the treatment of type 2 diabetes mellitus (T2DM). They are designed to lower high blood glucose levels typical in T2DM, and work by inhibiting the sodium-glucose transport protein 2. SGLT2i have also been shown to improve outcomes among…
, 2025-05-01 03:44:00 Difficulty finding words or the habit of substituting them with others that are similar semantically – such as knife and cutter – or phonologically – such as knife and wife – are usually the first symptoms of a type of dementia known as primary progressive aphasia (PPA). Another sign is a subtle…
, 2025-04-30 12:00:00 TOPLINE: Neonates born very preterm receiving 2 hours of immediate skin-to-skin contact (SSC) with their mothers showed no improvement in neurodevelopmental outcomes at 2-3 years of age, according to a Norwegian trial; however, SSC resulted in increased breastfeeding rates at hospital discharge (84% vs 67%; P = .04) and up to the…
Scott Buzby , 2025-04-30 15:00:00 April 30, 2025 3 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process…
Torie Bosch , 2025-04-30 08:30:00 In the 19th century, medical schools were desperate for corpses from which their students could learn. Grave robbers would sell bodies; sometimes, janitors, students, or even instructors would themselves dig up corpses. Today’s medical students don’t have to go into cemeteries themselves, but schools still struggle to find cadavers that…
, 2025-04-30 21:00:00 Credit: Unsplash/CC0 Public Domain Results from the ESSENCE Phase III clinical trial published in the New England Journal of Medicine show treating patients with semaglutide can halt and even reverse liver disease. The placebo-controlled outcome trial of participants with a life-threatening form of liver disease known as metabolic dysfunction associated steatohepatitis (MASH)…
, 2025-05-01 03:57:00 Women who suffer from endometriosis have an increased risk of premature and early menopause, both naturally and surgically, University of Queensland researchers have found. A comprehensive international study found women with endometriosis are at 7 times the risk of surgical menopause (involving the removal of both ovaries) and face a higher risk…
, 2025-04-30 12:01:00 Robert Den, MD, a radiation oncologist in Philadelphia, constantly reminds himself that while he’s in the ‘cancer world’ every minute of the day, his patients aren’t. “As oncologists, we may be meeting with the third patient that day with a newly diagnosed metastatic cancer, but for this individual, this is their first…
Michela Cimberle , 2025-04-30 18:30:00 April 30, 2025 13 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . ” data-action=subscribe> Subscribe We were unable to process your request. Please try again later….
Ed Silverman , 2025-04-30 12:01:00 Ed Silverman, a senior writer and Pharmalot columnist at STAT, has been covering the pharmaceutical industry for nearly three decades. In a significant move, the National Institutes for Health said it would reduce its reliance on animals in federally funded research and instead prioritize investment in human-based alternatives, the second…
, 2025-04-30 21:00:00 Credit: Pixabay/CC0 Public Domain An investigational gene therapy has successfully restored immune function in all nine children treated with the rare and life-threatening immune disorder called severe leukocyte adhesion deficiency-I, or LAD-I, in an international clinical trial co-led by UCLA. LAD-I is a genetic condition that affects approximately one in a million…
, 2025-05-01 02:58:00 Children with low vitamin D levels face a greater risk of early heart disease, according to a decades-long Finnish study. Could early supplementation shift the tide on cardiovascular prevention? Childhood 25-OH-vitamin D Levels Predict Early Cardiovascular Outcomes in Adulthood: The Cardiovascular Risk in Young Finns Study. Image Credit: Ekaterina Markelova / Shutterstock In a…
, 2025-04-30 12:30:00 MANCHESTER, England — Febuxostat (Uloric) did not appear to increase the risk for major adverse cardiovascular (CV) events (MACEs) when compared with no urate-lowering therapy (ULT) in people with gout, according to findings from a real-world, retrospective cohort study reported at the British Society for Rheumatology (BSR) 2025 Annual Meeting. Using data…
Marissa Plescia , 2025-04-30 22:42:00 Ask a provider what’s causing tension in their relationship with insurers and many will point to prior authorization, arguing that the practice creates administrative burdens and delays in patient care. In an effort to improve prior authorization, many insurers and states have introduced gold carding programs, in which providers with…
Justin Cooper , 2025-04-30 19:44:00 April 30, 2025 2 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process…
Jason Mast , 2025-04-30 12:26:00 Novartis said Wednesday it would buy Regulus Therapeutics and its experimental kidney drug for $800 million upfront. The immediate payout is more than triple Regulus’ current market cap. Novartis could pay another $900 million depending on whether the drug achieves an unspecified regulatory milestone. The deal could provide a bit…
, 2025-04-30 22:30:00 Credit: Unsplash/CC0 Public Domain ‘No-touch’ vein harvesting significantly reduces the risk of graft failure up to three years after coronary artery bypass surgery compared with conventionally harvested vein grafts, finds a study from China published by The BMJ. The no-touch technique also translates into meaningful clinical benefits for patients, such as lower…
, 2025-05-01 00:55:00 Cataracts are a prevalent ocular condition characterized by a progressive decline in vision, ultimately leading to blindness. Epithelial-to-mesenchymal transition and the subsequent migration of lens epithelial cells are major contributors to cataracts formation. Nonetheless, the mechanisms underlying this transition remain largely unknown. In a recent study published in the Genes & Diseases…
, 2025-04-30 12:34:00 A novel topical formulation of a BRAF inhibitor significantly reduced acneiform rash associated with anti–epidermal growth factor receptor (EGFR) therapies in patients with colorectal cancer, a new study found. This gel could improve treatment adherence, said Anisha B. Patel, MD, lead author of the phase 2 clinical trial, during her presentation of…
Katie Adams , 2025-05-01 00:14:00 This roundup is published monthly. It is meant to highlight some of healthcare’s recent hiring news and is not intended to be comprehensive. If you have news about an executive appointment, resignation or layoff that you would like to share for this roundup, please reach out to [email protected]. Hires Morgan…
Caitlyn Stulpin , 2025-04-30 20:58:00 April 30, 2025 2 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process…
Ismael M. Belkoura — Medill News Service , 2025-04-30 22:43:00 WASHINGTON — The Trump administration has cancelled federal participation in Safe to Sleep, a 30-year campaign to prevent babies from dying in their sleep, STAT and the Medill News Service have learned. The elimination of the National Institutes of Health’s role in the program, which…
, 2025-04-30 22:30:00 Credit: CC0 Public Domain Treatment with gabapentinoids—drugs such as gabapentin and pregabalin—is not directly associated with an increased risk of self-harm, finds a UK study published by The BMJ. However, rates of self-harm were higher before and shortly after treatment, highlighting the need for close monitoring of patients throughout their treatment journey,…
, 2025-04-30 23:19:00 A new review reveals how folic acid can act as both a friend and foe in breast cancer, protecting at moderate doses, but potentially fueling tumor growth when intake is excessive or genes go awry. Review: The Role of Folic Acid in DNA Methylation and Breast Cancer. Image Credit: Prostock-studio / Shutterstock A review…
, 2025-04-30 12:47:00 TOPLINE: In children with septic shock without known cardiac dysfunction, initial treatment with norepinephrine was associated with a lower 30-day mortality but similar rates of major adverse kidney events by 30 days (MAKE30) compared with epinephrine, a study reported. METHODOLOGY: Researchers conducted a single-center, retrospective cohort study of 231 patient encounters (median…
Frank Vinluan , 2025-04-30 22:51:00 Novartis has made kidney disorders an area of focus, and it’s now adding a new drug prospect through a deal to acquire Regulus Therapeutics, a biotech with a drug ready for pivotal testing in a rare renal disease that has limited treatment options. The Swiss pharmaceutical giant on Wednesday said…
Stephen I. Feller , 2025-04-30 21:27:00 April 30, 2025 2 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to…
Ed Silverman , 2025-04-30 22:30:00 Only 6.9% of people with drug-resistant infections in eight large, low- and middle-income countries received an appropriate antibiotic in 2019 and the lack of access was largely attributed to insufficient care, according to a new analysis. The researchers examined several antibiotics that were suitable to treat nearly 1.5 million cases…
, 2025-04-30 22:00:00 Credit: CC0 Public Domain A new, non-invasive breath test has emerged as a potential breakthrough for rapidly diagnosing bacterial infections and tracking treatment effectiveness. Developed by researchers from the University of California, San Francisco (UCSF) and St. Jude Children’s Research Hospital, the test leverages pathogen-specific metabolic tracers and a laser-based detection platform…
, 2025-04-30 17:37:00 Despite steady increases in rates of immediate breast reconstruction (IBR) after mastectomy, racial disparities in IBR have persisted in the years since implementation of the Affordable Care Act (ACA), reports a study in the May issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS). The journal is published…
, 2025-04-30 12:50:00 Graduating med students, ready to put med school in their rearview mirror figuratively and literally — in a car perhaps packed with clothes, books, an Ikea shelf, and a devoted beagle — also have no shortage of logistical challenges ahead of them. Finding a place to live and moving in, learning a…
, 2025-04-30 20:08:00 New York-based virtual care company Teladoc Health announced it acquired mental health platform UpLift in a deal worth $30 million. The acquisition reinforces Teladoc’s game plan to increase its leadership position in virtual mental health and the ability for consumers served by the company’s BetterHelp segment to get benefits coverage for mental…
Stephen I. Feller , 2025-04-30 21:17:00 April 30, 2025 2 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to…
Elaine Chen , 2025-04-30 13:27:00 Want to stay on top of the science and politics driving biotech today? Sign up to get our biotech newsletter in your inbox. Good morning, let’s get into all the updates from a busy earnings season so far. The need-to-know this morning GSK and United Therapeutics reported earnings. Novartis is acquiring Regulus…
, 2025-04-30 20:42:00 A new study details a novel rat model that closely replicates the pathological features and physiological changes associated with human chronic obstructive pulmonary disease (COPD)-associated cor pulmonale. This graphical abstract depicts the development and characterization of the model. Credit: American Journal Of Pathology (2025). DOI: 10.1016/j.ajpath.2025.01.003 Researchers have developed a novel rat…
, 2025-04-30 19:36:00 The use of nicotine pouches – small, easily concealed sachets of nicotine and additives that are placed between the gum and lip – nearly doubled among U.S. high school students between 2023 and 2024, according to a new USC study. The research, involving surveys of more than 10,000 teens from around the…
, 2025-04-30 20:11:00 The US Food and Drug Administration (FDA) has approved nipocalimab-aahu (Imaavy, Johnson & Johnson) for the treatment of generalized myasthenia gravis (gMG) in adults and adolescents 12 years of age and older, the company announced in a statement. The drug is the “first and only” human Fc receptor (FcRn)-blocking monoclonal antibody approved…
Luidgi Faubert , 2025-04-30 13:31:00 Diagnosing conditions requires accurate information. Patients get the best care and better outcomes with services like diagnostic imaging. Financial standing shouldn’t prevent people from accessing the imaging necessary to create a treatment plan. Health care leaders can explore the best options for diagnostic imaging covered by Medicare so every patient…
, 2025-04-30 18:58:00 Direct-to-consumer virtual care company Hims & Hers is partnering with Novo Nordisk to allow Americans to access a bundled offering that includes the pharma giant’s obesity drug Wegovy and a Hims & Hers membership starting at $599 per month. Hims & Hers members will have direct access to NovoCare Pharmacy, an offering…
Beth Malow, MD, MS; Robert Herpen, MA , 2025-04-30 18:30:00 April 30, 2025 3 min watch Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . ” data-action=subscribe> Subscribe We were unable to process your…
Ed Silverman , 2025-04-30 13:55:00 Hello, everyone, and how are you today? We are doing just fine, thank you, especially since the middle of the week is upon us. After all, we have made it this far so we are determined to hang on for another couple of days. And why not? The alternatives —…
, 2025-04-30 18:40:00 A close-up view illustrates the tracking of a study participant’s pupil and face. Credit: Mass Eye and Ear Researchers at Mass General Brigham have identified new biomarkers for tinnitus by measuring pupil dilation and subtle facial movements that correlate with the level of distress caused by the disorder. Published in Science Translational…
, 2025-04-30 17:41:00 Researchers from the University of California San Diego have found that Mindfulness-Oriented Recovery Enhancement (MORE) can help rewire the brain’s response to natural healthy pleasure, leading to improved mood, greater attention to positive experiences and reduced opioid cravings. The findings, published on April 30, 2025 in the Journal of the American Medical…
, 2025-04-30 15:00:00 TOPLINE: Ivarmacitinib, a selective oral Janus kinase 1 inhibitor, significantly improved signs and symptoms in patients with moderate to severe atopic dermatitis (AD) and showed a favorable safety profile in a phase 3 trial. METHODOLOGY: Researchers conducted a multicenter, double-blind, placebo-controlled phase 3 randomized trial of 336 patients aged 12-75 years (mean…
Nathan Price , 2025-04-30 13:47:00 Current medicine deploys an outdated “find it, then fix it” approach in which disease is diagnosed only after the onset of clinical symptoms, with treatments that merely ameliorate symptoms rather than addressing root causes. This begs the question: What if we could extend healthspan and prevent disease before it starts?…
, 2025-04-30 17:21:00 Healthcare software company Commure entered into a strategic partnership with virtual healthcare provider HealthTap to combine its EHR integrations, AI-enabled tools and care coordination abilities with HealthTap’s clinician network and virtual care delivery services. The companies say the alliance will allow health systems and other practices to provide expanded services, such as…