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Teladoc acquires UpLift for $30M, releases first quarter results

, 2025-04-30 20:08:00   Editor’s note: This article has been updated to include Teladoc’s first quarter 2025 earning results. New York-based virtual care company Teladoc Health announced it acquired mental health platform UpLift in a deal worth $30 million.  The acquisition reinforces Teladoc’s game plan to increase its leadership position in virtual mental health and…

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100 Days of Health Policy Upheaval

, 2025-05-01 18:40:00 The Host Members of Congress are back in Washington this week, and Republicans are facing hard decisions on how to reduce Medicaid spending, even as new polling shows that would be unpopular among their voters. Meanwhile, with President Donald Trump marking 100 days in office, the Department of Health and Human Services…

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Biotech leaders decry Trump disruptions in health and science

Jonathan Wosen , 2025-05-01 18:45:00 PALO ALTO, Calif. — At an annual meeting usually focused on the industry’s future, life science leaders couldn’t help but grapple — 100 days into President Trump’s second term — with a present clouded by uncertainty. At Stanford’s Drug Discovery Symposium, biotech bigwigs spoke openly this week about how the scientific…

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Kānuka extract shows promise in reducing organ transplant medication’s side effects

, 2025-05-01 18:44:00 Kānuka forest at Ahi-a-Te-Atua, Makarika, Tairāwhiti. Credit: Hikurangi Bioactives Limited Partnership. Researchers have identified a compound in an extract from native kānuka that may have the potential to limit the adverse effects of rapamycin, a drug primarily used as an immune suppressant in kidney transplants. “Our lab studies suggest that when this…

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Are US Cervical Cancer Screening Exit Criteria Failing?

, 2025-05-01 16:09:00 Cervical cancer screening guidelines in the United States have evolved considerably over the past few decades, reflecting advances in understanding how cervical cancer develops, the pivotal role that human papillomavirus (HPV) plays in driving carcinogenesis, and improved screening techniques. Despite these changes, concerns persist about whether current exit criteria — the guidelines…

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Backlash over Government suggestions that alcohol health labels will be delayed

Michael McHale , 2025-05-01 16:24:00 Alcohol Action Ireland describe attempts to link labelling with trading environment as ‘industry red herring’ The Government has been criticised for indicating that the introduction of health labels on alcohol products may be delayed. The new drinks labelling, which once implemented will include information on the harmful effects of alcohol…

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Plenful scores $50M and more funding news

, 2025-05-01 14:51:00 Plenful, a workflow-automation platform for pharmacy and healthcare operations, has secured $50 million in Series B funding, bringing its total raise to $76 million.  Dahner cofounder Mitchell Rales and Arena Holdings co-led the round, with participation from Bessemer Venture Partners, TQ Ventures, Notable Capital, Susa/Kivu Ventures and other investors.  The company will use…

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Madrigal, Biogen, Moderna, Eli Lilly, Novo

Elaine Chen , 2025-05-01 13:40:00 Want to stay on top of the science and politics driving biotech today? Sign up to get our biotech newsletter in your inbox. Good morning. I’m both excited and terrified to report that it’s May! Time flies when we’ve got lots of news. The need-to-know this morning Madrigal Pharmaceuticals reported $137.3 million…

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High fructose diets impair brain function and appetite control, study shows

, 2025-05-01 02:28:00 New research links high-fructose diets, especially from processed foods, to disrupted appetite signals and long-term brain changes, raising concerns for developing brains. Review: Mindful Eating: A Deep Insight Into Fructose Metabolism and Its Effects on Appetite Regulation and Brain Function. Image Credit: Oleksandra Naumenko / Shutterstock A recent review study published in the Journal…

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Expanded Indications for Hodgkin and CLL Drugs in Europe

, 2025-05-01 14:55:00 The European Medicines Agency’s (EMA) committee on human medicines has approved extended indications for two medicines used to treat Hodgkin disease and leukemia, respectively. In Hodgkin disease, Adcetris (brentuximab vedotin, Takeda Pharma A/S) is currently indicated for adult patients with previously untreated CD30+ stage III or IV Hodgkin lymphoma (HL) in combination…

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The ICHRA Moment Is Here — Are You Ready for It?

Jack Hooper , 2025-05-01 14:37:00 The ICHRA market isn’t just having a moment — it’s gaining maturity.  While new startups and investors are only now waking up to the opportunity, thousands of businesses are already offering flexible, portable health benefits to employees through Individual Coverage Health Reimbursement Arrangements. Forward-thinking employers are turning away from rigid…

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Talkspace, Bark Technologies partner to monitor children’s online activities

, 2025-05-01 14:56:00 Virtual teletherapy company Talkspace is teaming up with online digital safety platform Bark Technologies to offer Talkspace’s mental health offering free of charge to Bark phone and Bark app users.   Bark’s content monitoring platform aims to help families recognize potential dangers in children’s online activities. It provides mental health support by connecting…

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HHS urges therapy for transgender youth, not broader gender-affirming care

Associated Press , 2025-05-01 14:03:00 President Donald Trump’s administration released a lengthy review of transgender health care on Thursday that advocates for a greater reliance on behavioral therapy rather than broad gender-affirming medical care for youths with gender dysphoria. The 409-page Health and Human Services report questions standards for the treatment of transgender youth issued by…

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FDA-designated orphan drug could increase radiation efficacy in lung cancer

, 2025-05-01 14:10:00 Schematic illustrating how LIPT1 deficiency impairs the IR-induced, TIP60-ATM–mediated HR damage repair pathway due to a deficiency in α-KG–dependent demethylation. Credit: Science Advances (2025). DOI: 10.1126/sciadv.adt1241 An FDA-designated orphan drug that can target a key vulnerability in lung cancer shows promise in improving the efficacy of radiation treatments in preclinical models, according…

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Clusterin identified as key marker for aging in blood stem cells

, 2025-05-01 02:29:00 In recent years, there has been a growing trend of an aging patient population and an increasing prevalence of age-associated diseases, underscoring the need for advancing research into the biological mechanisms of aging. Of particular scientific interest are hematopoietic stem cells (HSCs), which undergo profound age-related phenotypic and functional transformations. HSCs, found…

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Another Win for ctDNA-guided Adjuvant Treatment

, 2025-05-01 13:41:00 Circulating tumor DNA (ctDNA) saw more success in guiding adjuvant therapy decisions, in a study presented at the American Association for Cancer Research (AACR) Annual Meeting 2025. The phase 2 trial screened for ctDNA in 174 patients with early-stage mismatch repair–deficient solid tumors — 16 types in all, the majority colorectal cancer…

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Expanding Support for Mail-Based Naloxone Delivery

Suhanee Mitragotri, Kevan Shah and Avik Chatterjee , 2025-05-01 13:25:00 Over a million lives have been lost to drug overdoses since the start of the overdose crisis, with  opioids accounting for 72% of these deaths. In 2023, the FDA approved naloxone (brand name Narcan) for over-the-counter purchase at pharmacies without a prescription. This marked a…

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Proposed bylaw changes aim to modernize the AAOS

Hunter Firment , 2025-05-01 13:05:00 Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process your request. Please try again later….

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Eli Lilly shares fall on earnings report, Novo coverage win

Elaine Chen , 2025-05-01 12:02:00 Shares of Eli Lilly dropped in pre-market trading Thursday, as competitor Novo Nordisk secured a major win on insurance coverage of its obesity drug and as Lilly reported first-quarter earnings that fell short of what investors wanted to see. CVS Caremark, the largest pharmacy benefit manager in the U.S., announced…

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Energy deficiency impacts collegiate running performance

, 2025-05-01 12:09:00 Study design observation occurred across a 10–12 weeks competitive cross country season. Credit: European Journal of Sport Science (2025). DOI: 10.1002/ejsc.12261 Collegiate female endurance runners who experience chronic energy deficiency throughout a competitive season may compromise their performance and training benefits, according to a recent study by researchers in the Penn State Department…

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Study links impaired synaptic pruning to autism

, 2025-05-01 02:33:00 Autism spectrum disorder (ASD) is a complex neurodevelopmental condition in which affected individuals experience difficulties in social communication and exhibit restricted, repetitive patterns of behavior or interests. A growing body of research suggests that neurobiological changes, particularly abnormalities in dendritic spines, tiny protrusions on nerve cells where synapses form, may be a…

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Oral, Injected Semaglutide May Pose Distinct Eye Risks

, 2025-05-01 12:00:00 TOPLINE:  An analysis of data from the US Food and Drug Administration Adverse Event Reporting System (FAERS) database revealed differences in patterns of ocular events associated with oral and injectable formulations of semaglutide, with injectable formulations linked to a higher frequency of retinal complications. METHODOLOGY: The FDA has approved semaglutide as both…

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M&A is back, but nothing in biotech is neat or simple

Adam Feuerstein , 2025-05-01 10:30:00 Adam Feuerstein is a senior writer and biotech columnist, reporting on the crossroads of drug development, business, Wall Street, and biotechnology. He is also a co-host of the weekly biotech podcast The Readout Loud and author of the newsletter Adam’s Biotech Scorecard. You can reach Adam on Signal at stataf.54….

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Brain-computer interface allows paralyzed users to customize their sense of touch

, 2025-05-01 09:00:00 Credit: Pixabay/CC0 Public Domain University of Pittsburgh School of Medicine scientists are one step closer to developing a brain-computer interface, or BCI, that allows people with tetraplegia to restore their lost sense of touch. While exploring a digitally represented object through their artificially created sense of touch, users described the warm fur…

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Researchers identify blood biomarkers linked to Long COVID symptoms

, 2025-05-01 02:59:00 Researchers at Karolinska Institutet have identified biomarkers in the blood associated with symptoms of long COVID, particularly severe respiratory disorders. The discovery can pave the way for future diagnosis and treatment. The results are published in the top-ranking scientific journal Nature Immunology. Long COVID, also known as Post COVID, is a condition…

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Can Immunotherapy Replace Surgery in Some Solid Tumors?

, 2025-04-30 11:41:00 Neoadjuvant treatment with a programmed cell death 1 (PD-1) inhibitor induces clinical complete response and leads to organ preservation in a high proportion of patients with early-stage, mismatch repair–deficient (MMRd) solid tumors — regardless of tumor type, new data from a phase 2 study showed. Six months of treatment with dostarlimab led…

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Can Immunotherapy Replace Surgery in Some Solid Tumors?

, 2025-04-30 11:41:00 Neoadjuvant treatment with a programmed cell death 1 (PD-1) inhibitor induces clinical complete response and leads to organ preservation in a high proportion of patients with early-stage, mismatch repair–deficient (MMRd) solid tumors — regardless of tumor type, new data from a phase 2 study showed. Six months of treatment with dostarlimab led…

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Existing therapies may help control chronic muscle inflammation in Duchenne muscular dystrophy

, 2025-05-01 03:01:00 A new study led by researchers at Hospital for Special Surgery (HSS) suggests that currently available therapies may help control chronic muscle inflammation in Duchenne muscular dystrophy (DMD), a severe condition that leads to muscle weakness and premature death. The study, published in PNAS, identifies new mechanisms that drive chronic muscle inflammation…

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Vitamins B6, B2 Rise After Exercise in Severe MS

, 2025-04-30 12:00:00 TOPLINE: In patients with multiple sclerosis (MS), higher disability scores were associated with lower levels of vitamin B6; however, endurance exercise resulted in an increase in levels of vitamins B6 and B2 in patients with greater disability, a secondary analysis of a new trial showed. METHODOLOGY: A total of 106 individuals with…

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TDP-43 dysfunction in brain blood vessels may drive Alzheimer’s and ALS progression

, 2025-05-01 03:23:00 Reduced levels of a critical protein are linked to devastating brain diseases like Alzheimer’s, frontotemporal dementia, and amyotrophic lateral sclerosis (ALS). Surprisingly, the protein shortage primarily affects the brain’s blood vessels. University of Connecticut researchers report in the April 16 issue of Science Advances that mutations in the TARDBP gene that reduce TDP-43 protein levels also…

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