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Sanofi, Novavax, Maze x Shionogi news

Want to stay on top of the science and politics driving biotech today? Sign up to get our biotech newsletter in your inbox. Hi all. Today we’re talking about improving the global reach of gene therapies, and about why offering access to ancestral populations could be so powerful. We see in a KFF survey that a majority…

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Study Says ‘Double Jointed’ People At Higher Risk Of Long COVID

Individuals with joint hypermobility, commonly termed “double jointed,” are more likely to experience persistent fatigue associated with long COVID. Researchers have found that hypermobile individuals have a 30% higher chance of not fully recovering from COVID-19 and suffering from lingering fatigue. While hypermobility is not proven to be a causal factor of long COVID, the…

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Alnylam, RSV, Genentech, Amgen, FDA latest

Alnylam Pharmaceuticals CEO discussed the expansion of their heart drug vutrisiran, which is effective in treating ATTR cardiomyopathy. The company’s stock reached an all-time high, exceeding $38 billion in market value. Merck’s new data suggests competition for AstraZeneca and Sanofi’s RSV prophylactic Beyfortus. The potential approval of clesrovimab could offer advantages over Beyfortus in preventing…

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Otsuka, Click Therapeutics get FDA clearance for prescription digital therapeutic

Otsuka Pharmaceuticals and Click Therapeutics have received FDA clearance for their smartphone-based prescription digital therapeutic, Rejoyn, for major depressive disorder. The six-week remote treatment program combines cognitive emotional training and therapeutic exercises to improve brain connections involved in depression. Expected to launch in 2024, Rejoyn is designed as a neuromodulatory mechanism to enhance brain function….

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Weight Loss Drugs Could Be A Treatment Option For Osteoarthritis: Says Study

A recent study has found that semaglutide injections, a drug commonly used for weight loss, can significantly reduce osteoarthritis symptoms, cutting pain levels by nearly 50%. Osteoarthritis is a degenerative joint disease that causes chronic pain and affects mobility. Semaglutide, a glucagon-like peptide-1 (GLP-1) drug, is known for weight loss and diabetes treatment but has…

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The rapid rise of the UK’s cancer vaccine trials

The feature article discusses mRNA technology in vaccines, excluding the mention of Provenge as it is not an mRNA vaccine for prostate cancer. The article delves into the advancements of mRNA vaccines, their potential impact on healthcare, and current challenges. Significant progress has been made with mRNA vaccines, especially during the COVID-19 pandemic. The article…

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Ongoing trial will evaluate efficacy of acupuncture as complementary therapy for glaucoma

Researchers are conducting a study to evaluate the efficacy of acupuncture as a complementary treatment for glaucoma. They have recruited 10 patients with glaucoma so far and aim to enroll a total of 50 participants. The study will assess the impact of acupuncture on intraocular pressure, cardiovascular parameters, and daily functionality. Preliminary results are expected…

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Study demonstrates sustained reduction in child mortality following educational interventions in low-resourced countries

A study conducted by Mass General Brigham showed a significant reduction in the mortality rates of intubated pediatric patients in El Salvador after the implementation of a low-cost quality improvement program. The study focused on improving clinical practices in pediatric intensive care units in low and middle-income countries to reduce child mortality rates, which are…

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Pregnancy-related proteins in tumors linked to worse survival in female lung cancer patients

, 2025-04-29 20:30:00 Credit: Unsplash/CC0 Public Domain Lung cancer can co-opt genes that normally help a fetus develop and evade the mother’s immune system. And while these pregnancy-specific glycoproteins (PSGs) can get activated in the cancers of both men and women, female patients had poorer outcomes, a Memorial Sloan Kettering Cancer Center (MSK) research team…

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Eli Lilly, AstraZeneca claim top spots in annual ranking

Matthew Herper , 2025-05-14 17:18:00 A consultancy’s new ranking of drug company R&D shows Eli Lilly has risen to the top of the drug development heap — but when it comes to invention, AstraZeneca, with its wealth of experimental cancer and rare disease therapies, ranks above its peers. The assessment, which is conducted by U.K.-based…

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New light-based 3D printing technique advances tissue engineering

, 2025-05-13 17:08:00 Researchers at the Terasaki Institute for Biomedical Innovation (TIBI) have developed a technique that could help advance treatments in tissue engineering. The study, published in the scientific journal Small, introduces a technique for producing tissues with precise cellular organization designed to mimic the natural structure of human tissue. Using a simple light-based…

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What does Carequality investigation of Epic v. Particle dispute show

Carequality released new information about the dispute between Epic Systems and Particle Health, which has escalated into an antitrust lawsuit. Epic accused Particle of violating rules by sharing health data with customers. In response, Particle accused Epic of trying to destroy its business unfairly. The lawsuit claimed that Epic influenced Carequality’s adjudication process. Carequality, a…

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MaxCyte celebrates 25 years of innovation driving cell engineering-based therapeutics

MaxCyte, a cell-engineering company, celebrates its 25th anniversary, focusing on providing enabling technologies for cell therapeutics development. The company offers Flow Electroporation technology, part of their proprietary ExPERT platform, to support biomedical innovations in human health. MaxCyte has signed 29 Strategic Platform License agreements with cell therapy developers, including the development of the FDA-approved CASGEVY®…

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Seven Trends to Watch in Healthtech AI

In 2024, the healthcare industry is closely watching the evolving role of AI. Seven key trends to watch this year include EHR integration, the use of imaging in radiology, flexibility with data, the impact of AI on prior authorization rules, the need to avoid volatility with AI implementations, the importance of thinking three steps ahead,…

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Survey of US adults reveals common cognitive symptoms in post-COVID-19 patients, linked to impaired daily functioning and depression

A study published in JAMA Network Open evaluated cognitive symptoms in individuals with post-COVID-19 condition compared to those who had recovered from SARS-CoV-2 infections. The study found a high prevalence of cognitive symptoms in those with long COVID, which was associated with functional impairments and lower likelihood of full-time employment. There was also a greater…

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OxygenCare announces new partnership to improve access to life-saving defibrillators in Ireland

Cardiovascular disease is a leading cause of death in Ireland, with 9,000 deaths and 25,000 hospital admissions annually. OxygenCare partners with Defibtech to improve access to life-saving defibrillators in Ireland. Defibtech, a trusted American manufacturer, aims to provide reliable and affordable resuscitation devices globally. The partnership aims to ensure that defibrillators are available and functional…

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Details From Head-to-Head Phase 3 Test Give Fuller Picture of Zepbound’s Edge Over Wegovy

Frank Vinluan , 2025-05-12 17:50:00 Eli Lilly already posted preliminary data showing its obesity drug, Zepbound topped Novo Nordisk’s Wegovy on measures of weight loss in a head-to-head clinical trial. More detailed results, including key secondary measures of the Phase 3 study, give greater insight into the comparison, including a key measure that analysts say…

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Exploring the role of chemokines in atrial fibrillation development

A new article in Cardiovascular Innovations and Applications journal discusses the role of chemokines in atrial fibrillation (AF), the most common cardiac rhythm condition. Levels of chemokines like CXCL8, CXCR2, CXCL12, and CXCR4 have been linked to AF development and progression, suggesting a potential role in atrial remodeling. The CXCL12/CXCR4 axis is particularly elevated in…

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7 Study Apps Help Med Students Prep for Exams

Students in medical school are increasingly turning to digital study apps to help them absorb and retain complex medical information needed to pass licensing exams. Popular study tools include UWorld, AMBOSS, Sketchy, Boards & Beyond, Pathoma, Anki flashcards, NBME self-assessments, and AMA practice questions. These apps offer a mix of practice questions, videos, interactive review…

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Five year hypertension study provides further evidence of the benefits of fruit and vegetable consumption

Doctors recommend incorporating fruits and vegetables into the treatment of patients with hypertension as they can lower blood pressure, reduce cardiovascular risk, and improve kidney health. A study published in The American Journal of Medicine found that the DASH diet, rich in fruits and vegetables, can be an effective first-line treatment for hypertension. The study…

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FDA Approves Iloperidone for Bipolar Disorder

The FDA has approved iloperidone tablets for the treatment of manic or mixed episodes associated with bipolar I disorder in adults. Iloperidone is an atypical antipsychotic that acts as a dopamine D2/serotonin 5-HT2A receptor antagonist. The approval was based on a phase 3 trial showing significant improvement in symptoms with iloperidone compared to placebo. The…

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AI aids analysis of lifetime environmental exposures

Credit: CC0 Public Domain The idea that biology is not destiny is hardly new. Studies in twins have shown that even among identical pairs—those sharing 100% of their DNA—the same disease genes do not turn into full-blown illness in both individuals. Most human diseases are fueled by both genetic and environmental factors. Genes account for…

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Rosacea, melanoma linked in white patients

A study found that patients with rosacea are at an increased risk for malignant melanoma, joint problems, metabolic disease, and visual disturbances. The study used the TriNetX platform to analyze real-world patient data and found a strong association between rosacea and skin cancer. The risk of melanoma was notably higher in patients with rosacea compared…

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Trump-ordered NIH contract terminations cut deep

Megan Molteni and Jason Mast , 2025-05-09 08:30:00 Jay Tischfield prides himself on his long track record of cellular custodianship. As the founding director of the Human Genetics Institute of New Jersey at Rutgers University, he maintains one of the largest university-based DNA banks in the world — much of it, on behalf of the…

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Ending nuclear weapons, before they end us

Kamran Abbasi, Parveen Ali, Virginia Barbour, Marion Birch, Inga Blum, Peter Doherty, Andy Haines, Ira Helfand, Richard Horton, Kati Juva, Jose F Lapena, Jr, Robert Mash, Olga Mironova, Arun Mitra, Carlos Monteiro, Elena N Naumova, David Onazi, Tilman Ruff, Peush Sahni, James Tumwine, Carlos Umana, Paul Yonga, Chris Zielinski , 2025-05-13 13:46:00 In May 2025…

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LG launches Primefocus Health for providers to deliver home healthcare

LG Electronics has launched Primefocus Health, a new venture that will develop a healthcare delivery platform for providers. This platform will use technologies and therapies for remote patient monitoring and providing access to new therapies through technology applications. Providers will be able to collect patient data, communicate with patients, track progress, and intervene when necessary….

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General Catalyst leads in-home care provider HarmonyCares $200M round

HarmonyCares, a physician-led primary care provider, secured $200 million in funding led by General Catalyst, with participation from other investors. The company specializes in treating older adults with serious health conditions in their homes, offering a team of primary care providers, pharmacists, social workers, and nurse case managers. They provide 24/7 on-call support and partner…

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What’s keeping the US from allowing better sunscreens?

When dermatologist Adewole “Ade” Adamson sees people spritzing sunscreen as if it’s cologne at the pool where he lives in Austin, Texas, he wants to intervene. “My wife says I shouldn’t,” he said, “even though most people rarely use enough sunscreen.” At issue is not just whether people are using enough sunscreen, but what ingredients…

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GoodRx Expands Women’s Health Options with New Birth Control and Menopause Offerings

GoodRx, a prescription savings platform, launched its new e-commerce solution with over-the-counter birth control pill Opill as its partner, offering delivery services. Opill, the first OTC birth control pill in the U.S., aims to expand access to contraception. GoodRx also introduced affordability programs for menopause hormone therapies from Pfizer, providing lower prices for drugs like…

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Health Catalyst acquires Lumeon | MobiHealthNews

Health Catalyst acquired Lumeon, a care management automation startup, to enhance revenue and reduce staff workload. Health Catalyst plans to integrate Lumeon’s Care Orchestration technology into their AI and analytics platform. The acquisition will also allow Health Catalyst to expand into the UK market. In addition, Health Catalyst has announced partnerships with Contexture and South…

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Adaptimmune’s FDA Approval Marks the First for an Engineered Cell Therapy for Solid Tumors

Adaptimmune Therapeutics has received FDA approval for its engineered cell therapy, Tecelra, to treat synovial sarcoma, a rare solid tumor. Tecelra, which targets the MAGE-A4 antigen, showed promising results in a Phase 2 clinical trial with a 43% overall response rate. The therapy comes with potential side effects such as cytokine release syndrome and neurotoxicity….

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More African nations focus on HPV vaccination against cervical cancer, but hesitancy remains

African countries are working to vaccinate more young girls against the human papillomavirus (HPV) to reduce rates of cervical cancer, which is high in the region. However, misinformation and vaccine hesitancy, fueled by rumors and religious beliefs, pose challenges. Despite efforts by health workers, only a few countries have reached the 90% coverage goal. Limited…

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Single-cell profiling methods compared for gut biopsy analysis

, 2025-04-15 09:39:00 Credit: Cellular and Molecular Gastroenterology and Hepatology (2025). DOI: 10.1016/j.jcmgh.2025.101503 Research on gastrointestinal diseases, especially cancer, has mainly focused on epithelial cells, which line the surfaces of organs, are important for various functions, and are believed to be the cells that go awry to cause these diseases. However, studying these cells using…

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