A team of researchers at Rice University led by Anna-Karin Gustavsson has developed the soTILT3D imaging platform for nanoscale cellular structure analysis. It improves super-resolution microscopy by allowing fast and precise 3D imaging of multiple cellular structures with controlled extracellular environments. Traditional microscopy is limited by light diffraction, while existing super-resolution techniques face challenges like high background fluorescence and slow imaging speeds. The soTILT3D platform addresses these issues by using an angled light sheet, a custom microfluidic system, and computational tools. It offers enhanced precision and speed, helping researchers study cellular interactions at the nanoscale more clearly and efficiently.
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Nanoscale cellular interactions unveiled by the SoTILT3D imaging platform
