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Feds threaten Sanofi over proposed 340B changes

The U.S. government agency Health Resources & Services Administration warned Sanofi about facing sanctions for changing payment methods in the 340B Drug Discount Program. The agency stated that Sanofi could be terminated from the program if it proceeds with the changes without approval from the Department of Health and Human Services. Sanofi planned to provide…

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Architecture and public health: from harmful designs to healthy built environments

Architectural health research conducted by Cleo Valentine emphasizes the importance of creating happier and healthier built environments, especially in urban areas where over half of the world’s population resides. The built environment can have a significant impact on public health, and it is crucial for architects, developers, and authorities to collaborate and prioritize health considerations…

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AI tool could revolutionize placenta examination and improve neonatal care

Researchers from Northwestern Medicine and Penn State have developed a tool called PlacentaVision that uses computer vision and AI to analyze photographs of the placenta to detect abnormalities associated with infection and neonatal sepsis. The tool could potentially improve neonatal and maternal care by providing early identification of placental infection. PlacentaVision is intended to be…

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‘If I Think It’s Dangerous’

President-elect Donald Trump suggested the possibility of removing some vaccinations if he deems them dangerous during an interview with TIME. This comment came in relation to his nomination of Robert F. Kennedy Jr., who has expressed skepticism about vaccines in the past. Despite claims that vaccines cause autism being debunked by medical professionals, Trump expressed…

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Why Expanding Access to Alternative Drug-free Pain Management May be the Key to Improving Chronic Pain Patient Outcomes

Chronic pain affects around 50 million adults in the U.S. and is often misunderstood by healthcare professionals. The use of prescription opioids for pain management has led to addiction and other risks. Research suggests that chronic pain may be linked to the brain’s perception of pain rather than structural issues in the body. Chiropractic care,…

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Department of Health launches Ireland’s first National Mental Health Research Strategy

Ireland has launched its first National Mental Health Research Strategy, aligning with the national mental health policy ‘Sharing the Vision’. The strategy aims to enhance mental health services and supports in Ireland by increasing funding, prioritizing research areas, strengthening research infrastructure, and collaborating with stakeholders. An oversight group will ensure the strategy’s goals are achieved….

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Study unveils key mechanism behind prostate cancer’s uncontrolled growth

Prostate cancer hijacks the normal growth regulation program of the prostate by reprogramming the androgen receptor to promote cell growth. Researchers from Weill Cornell Medicine discovered that the androgen receptor, usually responsible for maintaining healthy prostate cells, is altered in cancer to drive tumor development. The study identified genes that normally suppress cell growth but…

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Wound HealingToolbox Requires Frequent Updating

Instructions on wound healing can involve disturbing images, but day-to-day dermatologic wound care focuses on basics and innovative approaches. Dermatologists are at the forefront of wound repair, making and repairing more wounds than any other specialty. Clinical pearls discussed by wound treatment expert Robert S. Kirsner included repurposing drugs like dupilumab and topical beta-blockade for…

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The Role of Marketing in Building Trust Between Providers and Patients

The healthcare industry is facing challenges that have eroded patient trust and increased dissatisfaction. Effective marketing and communication strategies are essential to rebuild trust in healthcare systems and combat misinformation. Transparency, consistency, and empathy are key pillars in building trust, along with personalized communication, combating misinformation, and leveraging digital tools for engagement. Healthcare organizations must…

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St James’s wins ‘Golden Hip’ award for fracture care

St James’s Hospital in Dublin has been honored with the ‘Golden Hip’ award for its excellence in hip fracture care. The hospital demonstrated its commitment to improving outcomes for patients by implementing the ‘Code Hip’ initiative, which improved compliance with Irish hip fracture standards. They have consistently achieved high compliance rates for admission to orthopaedic…

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Novo Holdings set to close $16.5 billion Catalent deal

Novo Holdings, the parent company of Novo Nordisk, has received approval to proceed with its $16.5 billion acquisition of Catalent, a contract drug manufacturer. U.S. regulators have declined to challenge the deal, and the companies expect to close the transaction in the next few days. The European Commission has also approved the deal. The acquisition…

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ZEST trial fails to meet enrollment goals for ctDNA testing in breast cancer

The ZEST clinical trial aimed to evaluate niraparib for preventing breast cancer recurrence in patients with ctDNA, but failed due to low patient enrolment. Lessons learned include starting ctDNA testing during treatment, including high-risk patients to increase ctDNA-positive cases, and intervening promptly with appropriate therapies for MRD. Detecting ctDNA post-treatment is crucial for preventing recurrence….

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Self-Replicating mRNA Vaccine for COVID Prevention

The European Committee for Medicinal Products for Human Use (CHMP) recommended granting marketing authorization for two drugs to prevent COVID-19: Kavigale, a monoclonal antibody, and Kostaive, a self-amplifying mRNA vaccine. Kavigale contains sipavibart, an immunoglobulin that binds to the spike protein of SARS-CoV-2. Kostaive includes zapomeran, a self-replicating mRNA that induces the production of neutralizing…

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Texas Republican Seeks to Ban Sex Toys from Pharmacies to Keep Kids from ‘Being Exposed to Obscene Devices While Shopping for Toothpaste’

Republican Rep. Hillary Hickland from Texas wants sexually explicit items removed from common stores like Walmart and Target to protect children. She filed HB 1549 to limit the sale of sex toys to adult-oriented businesses only, citing concerns about protecting children’s innocence while shopping. The bill aims to prevent regular retail stores from selling such…

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A finely balanced decision

The England and Wales Court of Protection considered whether an elderly lady with serious memory impairment, living in residential care, had the capacity to engage in sexual relationships. The lady, PS, had been in a loving relationship with WP for two decades, despite her memory impairment and alcohol-related issues. Expert evidence suggested that with a…

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Decreasing comorbidities among BIPOC groups could lessen hospitalization disparities

The study highlights the disproportionate hospitalization and mortality rates among BIPOC populations during the COVID-19 pandemic. Increasing vaccination and reducing comorbidities among BIPOC communities can help decrease race-based hospitalization disparities. Interventions such as equalizing vaccination rates, reducing work exposures, and decreasing comorbidities showed promising results in balancing out symptomatic infection rates and hospitalizations among different…

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Japanese researchers test pioneering drug to regrow teeth

Japanese dentists are testing a pioneering drug that may allow people with missing teeth to grow new ones, avoiding the need for dentures or implants. The drug works by jumpstarting the growth of dormant third-generation teeth buds hidden beneath the gums. Clinical trials have shown promising results in regrowing teeth in mice and ferrets by…

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Exploring the cytotoxic potential of neocryptolepine derivatives against cancer

A new publication in Acta Materia Medica journal discusses the potential of neocryptolepine and its derivatives in cancer treatment. The article outlines the structures of 228 neocryptolepine derivatives, with some showing promising cytotoxic effects on cancer cells. The study highlights compounds that have good cytotoxicity against gastric and colorectal cancer cells, with potential mechanisms of…

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Rytelo Recommended in Europe for Myelodysplastic Syndromes

The European Medicines Agency (EMA) has recommended the use of Rytelo (imetelstat) for adult patients with transfusion-dependent anemia due to myelodysplastic syndromes, a group of cancers affecting blood cells in the bone marrow. These diseases can lead to fatigue, infections, and bleeding disorders, with a risk of developing acute myeloid leukemia. Imetelstat blocks telomerase activity,…

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Impact of long Covid revealed in new survey

A recent survey conducted in Ireland found that self-reported long Covid symptoms are more common among women and those in their forties. The most common symptoms reported by those still experiencing long Covid include fatigue, cognitive issues, joint or muscle pain, sleep disturbances, and breathlessness. The study involved 4,671 participants, with 16% reporting ever experiencing…

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California’s ‘Care Courts’ Are Falling Short

California’s Care program, which orders mental illness and drug treatment for residents, has expanded statewide but is falling short of objectives. The program allows for court-ordered treatments including housing and social services for those with severe mental illness or addiction. Despite initial goals to serve 2,000 people by 2024, only 787 Care petitions were filed…

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Obesity rates decline for first time in a decade

A recent study published in JAMA Health Forum revealed a decrease in the prevalence of obesity in the United States in 2023, marking the first drop since 2013. The study found a slight decrease in mean population BMI in 2023 compared to the previous year, after almost a decade of steady increases. GLP-1 receptor agonists…

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Editas layoffs, Elon Musk, and Trump

Sign up for the biotech newsletter to stay informed about the latest developments in the field. Editas Medicine is laying off staff and shifting focus to in vivo gene editing. Ionis Pharmaceuticals is changing its commercialization strategy to maximize profit. There are disagreements in Trump’s circle regarding GLP-1 drugs. Drugmakers are not lobbying against RFK…

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We need to transform women’s healthcare to tackle “medical misogyny”

Geeta Nargund, founder of Create Health Foundation, addresses the issue of “medical misogyny” affecting women in the UK in a recent report. The report emphasizes the urgent need for healthcare professional education to improve diagnosis and treatment of reproductive health conditions. Lack of investment in women’s health issues like endometriosis and menopause costs the UK…

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EMA Endorses Two ADHD Treatments for Children

The European Medicines Agency (EMA) has recommended marketing authorizations for two treatments for children with attention-deficit hyperactivity disorder (ADHD). Paxneury, containing guanfacine, has been approved for reducing ADHD symptoms such as hyperactivity and impulsivity. It will be available as prolonged-release tablets. The EMA also recommended Tuzulby, containing methylphenidate hydrochloride, for once-daily dosing to improve attention…

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UCLA Student Sues Doctors, Claims She Was Misdiagnosed Of Gender Dysphoria, And ‘Fast-Tracked’ Into Transgender Surgery

A UCLA student, Kaya Clementine Breen, is suing California doctors for allegedly misdiagnosing her with gender dysphoria at age 12, leading to irreversible gender transition treatments. Breen was sexually abused as a child, leading to anxiety, depression, and PTSD. At 11, she expressed doubts about her gender and was quickly diagnosed as transgender at school…

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Redesign Health Raises $175M to Create Dozens More Startups 

Redesign Health, a company focused on creating healthcare startups, has closed a $175 million investment for a new fund to support the creation of more startups. Some venture firms participating in the funding round include Declaration Partners, Euclidean Capital and True North Advisors. Redesign helps founders navigate the complexities of healthcare by providing support in…

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GP in County Westmeath

The HSE is looking for a General Practitioner for the GMS Scheme in Coole, Co Westmeath. The panel size is approximately 2,118 as of December 5, 2024. The premises are owned by a property group, and potential applicants must discuss the lease/rental of the premises before applying. Contact details for the property group can be…

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Addressing vaccine hesitancy; tapinarof cream for itch relief

Researchers found that vaccine hesitancy is more common among patients who seek information from the media and the internet. Factors such as social media algorithms, anti-vaccine tweets, and conspiracy theories drive patients’ hesitancy. Physicians recommend shared decision-making to address this issue, emphasizing the importance of understanding patients’ perspectives and building trust through storytelling. In another…

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South African regulator decides Vertex provides sufficient access to CF drugs

South African regulators have determined that Vertex Pharmaceuticals has adequately provided access to its cystic fibrosis medications, resolving a controversy over treatment costs. Patient activists are unhappy with the decision, arguing that the arrangement is unfair and will result in some patients continuing to suffer and die. This issue began when families and activists petitioned…

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