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Study highlights struggles of GPs in deprived neighborhoods

, 2025-04-22 10:35:00 Credit: MART PRODUCTION from Pexels English GPs in areas of socioeconomic deprivation endure increased job pressures related to managing complex patients, insufficient resources, and difficulty in finding locum cover, an analysis by University of Manchester researchers has shown. The researchers suggest that policymakers should increase funding so that deprivation is taken into…

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How to Make the Most of It

, 2025-04-22 09:56:00 The clinical training part of medical school means you finally get to put all the book learning, lectures, laboratories, and other preliminary lessons into practice. But it’s more than just the application of recently acquired knowledge. Rotations not only give you a chance to develop skills and care directly for patients but…

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New Ultrasound Protocols to Detect Atherosclerosis Early

, 2025-04-22 07:39:00 Clinical ultrasound is invaluable for detecting atherosclerosis. However, methods to assess vascular areas with atheromatous plaques and their extent remain inconsistent and lack standardisation. To address this, the Spanish Society of Internal Medicine and the Spanish Society of Hypertension and Vascular Risk published two protocols for vascular risk assessment: VAScular UltraSound (VASUS)…

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Mistrust in science and medicine

Leonard H. Calabrese, DO , 2025-04-21 13:41:00 April 21, 2025 2 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable…

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Basal cell carcinoma’s low immunogenicity linked to suppression of antigen presentation from its cell of origin

, 2025-04-22 06:55:00 Basal cell carcinoma has low immunogenicity. Tumor cells express Foxc1 protein (red), which suppresses HLA class I (green) in the tumor cells. Credit: Shawn Demehri, Massachusetts General Hospital Compromised antigen presentation ranks among the top mechanisms that render cancers non-immunogenic (non-responsive to immune-based therapies). Despite harboring the highest tumor mutational burden of…

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Psilocybin use surges across all age groups since 2019

, 2025-04-22 03:29:00 Use of psilocybin, the hallucinogenic chemical found in what is known as “magic mushrooms,” has increased significantly nationwide since 2019, according to a new study led by researchers at the University of Colorado Anschutz Medical Campus and Rocky Mountain Poison and Drug Safety. The study was published today in the Annals of…

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Pricey New Hemophilia A Drug Shows Limited Value

, 2025-04-22 06:32:00 TOPLINE: Prophylaxis with efanesoctocog alfa, while reducing annualized bleeding rate by 77% compared with standard-care factor VIII in severe hemophilia A, is not cost-effective at current US pricing, requiring a > 47% price reduction to meet cost-effectiveness thresholds. METHODOLOGY: A Markov cohort model was constructed using data from the XTEND-1 study, which…

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Customer service in dry eye: You have a choice

Darrell E. White, MD , 2025-04-21 14:18:00 April 21, 2025 5 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . ” data-action=subscribe> Subscribe We were unable to process your request. Please try…

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A silent threat to brain development and public health

, 2025-04-22 05:00:00 Medication-induced disruption of sterol biosynthesis poses significant risks to brain development and function. Credit: Julio Licinio An editorial published in Brain Medicine raises the alarm about a previously overlooked threat to brain development and public health: the disruption of sterol biosynthesis by common prescription medications. The editorial, “Medication-induced sterol disruption: An overlooked…

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Groundbreaking initiative launched to tackle environmental risks facing children

, 2025-04-22 03:34:00 University of Oklahoma researchers recently launched the Children’s Environmental Health Center in the U.S. Southern Great Plains, a groundbreaking initiative dedicated to advancing research on children’s health and environmental exposures, following a year of preparation. Funded by a $1.8 million grant from the U.S. Environmental Protection Agency, this new center aims to…

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A Key Factor in Unexplained Stroke in Young Adults

, 2025-04-21 11:37:00 Migraine with aura is the most prominent individual risk factor for unexplained stroke in adults younger than 50 years, particularly in women and in those with patent foramen ovale (PFO), a new study showed. While investigators found that both traditional and nontraditional risk factors contributed significantly to cryptogenic ischemic stroke (CIS) risk…

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Middle-aged Americans report higher loneliness than older adults, global study finds

, 2025-04-22 04:10:00 Credit: Unsplash/CC0 Public Domain Middle-aged Americans have demonstrated some of the highest levels of loneliness in a new study assessing tens of thousands of 50-to-90-year-olds across 29 countries. The research, published in Aging & Mental Health, shows that loneliness generally increases with age—with only the United States and the Netherlands representing places…

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Study Maps How Exosomes Hijack Blood Formation

, 2025-04-22 02:38:00 TOPLINE: Chronic lymphocytic leukemia (CLL) cell–derived exosomes demonstrated the ability to alter healthy donor cell function and suppress normal blood cell formation. These particles affected monocytes, fibrocytes, and lymphocytes, leading to changes in gene expression and protein levels that may contribute to disease progression. METHODOLOGY: Researchers examined CLL cell–derived exosomes and their…

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Adverse pregnancy outcomes partly mediate association between prepregnancy obesity, cardiovascular disease risk

, 2025-04-21 18:40:00 Adverse pregnancy outcomes (APOs) mediate a small proportion of the association between prepregnancy obesity and cardiovascular disease (CVD) risk in midlife, according to a study published in the April 22 issue of the Journal of the American College of Cardiology. Jaclyn D. Borrowman, Ph.D., from Northwestern University in Chicago, and colleagues examined…

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Pilocarpine eye drops improve outcomes after Kahook Dual Blade goniotomy surgery

, 2025-04-22 02:42:00 Using pilocarpine eye drops following Kahook Dual Blade (KDB) goniotomy surgery may improve clinical outcomes for patients with glaucoma and reduce the need for future medications, according to new research published by faculty members and trainees in the Department of Ophthalmology at the University of Colorado School of Medicine. “The KDB goniotomy is a minimally invasive glaucoma…

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Do Eating Behaviors Affect Obesity?

, 2025-04-21 11:39:00 Emerging evidence suggests that how you eat, as well as what you eat, can have an impact on obesity. Recent research showed that the number of chews and bites and meal duration can affect feelings of hunger and satiety and, by extension, how much food is consumed. In a recent small study…

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Harvard sues Trump administration over funding freeze

Mike Damiano — Boston Globe and Hilary Burns — Boston Globe , 2025-04-21 22:00:00 Harvard University sued the Trump administration on Monday, alleging that the government’s campaign to alter the school’s policies while cutting off research funding is unconstitutional. In a lawsuit filed in federal court in Boston, the university’s lawyers argued that the government’s “attempt…

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Hormone therapy may improve heart health in menopausal women

, 2025-04-21 19:22:00 Credit: RDNE Stock project from Pexels Deciding whether to start hormone therapy during the menopause transition, the life phase that’s the bookend to puberty and when a woman’s menstrual cycle stops, is a hotly debated topic. While hormone therapy—replacing the hormones that were previously produced by the body with synthetic medication—is recommended…

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Look Right for Signs of PAH Treatment Success

, 2025-04-21 11:48:00 To assess how a patient with pulmonary arterial hypertension (PAH) is faring on therapy, look at the right heart, said Anjali Vaidya, MD, in a presentation at the Annual Meeting of the American College of Cardiology. When it comes to right heart performance, “the echo doesn’t lie,” said Vaidya, a professor of…

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NIH’s Jay Bhattacharya says Trump DEI orders ‘misunderstood’

Jonathan Wosen , 2025-04-21 22:13:00 National Institutes of Health director Jay Bhattacharya on Monday asserted that the agency remains committed to research that advances the health of minorities — despite the Trump administration’s sharp focus on rolling back programs dealing with diversity, equity, and inclusion. Bhattacharya said that President Trump’s executive orders, which state that…

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Gut microbiome pattern predicts future heart attack risk in coronary heart disease patients

, 2025-04-21 23:48:00 Scientists have identified a gut microbiota profile that can help forecast future cardiovascular events in patients with heart disease, paving the way for more personalized treatment and early interventions. Study: A microbiota pattern associated with cardiovascular events in secondary prevention: the CORDIOPREV study. Image Credit: Shutterstock AI Generator / Shutterstock.com A recent study…

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Immune Side Effects Tied to Better SCLC Survival

, 2025-04-21 12:00:00 TOPLINE: Immune-related adverse events (irAEs) were associated with significantly improved progression-free survival (PFS) and overall survival (OS) in patients with extensive-stage small cell lung cancer (SCLC) who received chemoimmunotherapy compared with that in those who did not experience such events. METHODOLOGY: Researchers conducted a retrospective analysis of 399 consecutive patients (median age,…

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Combining brain stimulation with speech therapy shows promise for restoring language in primary progressive aphasia

, 2025-04-21 21:13:00 Credit: Pixabay/CC0 Public Domain Primary progressive aphasia is a neurological condition that causes a gradual decline in language abilities. There is no cure or medication that can reverse or stop the progression of PPA. The standard practice in the clinical setting is speech-language therapy to help people with PPA maintain their ability…

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Obesity Is a Risk Factor for Remission Failure in Early RA

, 2025-04-21 12:00:00 TOPLINE:  Patients with obesity and early rheumatoid arthritis (RA) had an increased risk for remission failure after 6 months of starting methotrexate treatment, regardless of the presence of underlying comorbidities.  METHODOLOGY: Researchers analysed data from a population-based case-control study linked to the Swedish Rheumatology Quality Register to investigate the association of obesity…

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Aeroflow Health Unveils New Diabetes Management Program

Marissa Plescia , 2025-04-21 20:32:00 Aeroflow Health, a health tech company, last week announced a new diabetes management program, which aims to improve adherence, outcomes and care coordination for health plan members. Asheville, North Carolina-based Aeroflow Health was founded in 2001 and offers an array of medical devices covered by insurance. The company has four…

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White House new COVID-19 page promotes Wuhan lab leak theory

, 2025-04-21 18:34:00 The White House has replaced a federal website that provided information about COVID-19 with a web page titled “Lab Leak: The True Origins of COVID-19” that cites the controversial theory that the virus was leaked from a Wuhan lab in China. The previous websites, covidtests.gov and covid.gov, provided information on treatment options…

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