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Serum hsa_circ_101555 as a promising biomarker for hepatocellular carcinoma

, 2025-04-25 03:06:00 Hepatocellular carcinoma (HCC) represents the most prevalent malignancy in Egypt and globally. However, non-invasive diagnostic/prognostic biomarkers for early detection of HCC are still lacking. Circular RNAs (circRNAs) are one of the promising biomarkers. They are considered stable, long-stranded non-coding RNAs in a sealed circular form held together by covalent bonds. circRNAs have…

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Young Women Binge Drinking at Higher Rates Than Men

, 2025-04-24 11:34:00 TOPLINE: Past-month binge drinking between 2021 and 2023 was higher among young adult women than among men, reversing a recent period. However, men still drank more heavily than women overall. METHODOLOGY: Researchers conducted a cross-sectional analysis using data from the National Survey on Drug Use and Health that included adults aged 18…

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Readout LOUD podcast: Pharma tariffs loom

Elaine Chen, Adam Feuerstein, and Allison DeAngelis , 2025-04-24 19:00:00 Adam Feuerstein is a senior writer and biotech columnist, reporting on the crossroads of drug development, business, Wall Street, and biotechnology. He is also a co-host of the weekly biotech podcast The Readout Loud and author of the newsletter Adam’s Biotech Scorecard. You can reach…

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Network pharmacology analysis reveals HXTL mechanism in treating postmenopausal osteoporosis

, 2025-04-25 03:37:00 Background and objectives Huo Xue Tong Luo Capsule (HXTL) has been clinically used to treat osteonecrosis of the femoral head, osteoporosis, and other bone and joint diseases with promising effects. Our previous study has shown that HXTL can promote osteogenesis in mesenchymal stem cells by inhibiting lncRNA-Miat expression through histone modifications. However,…

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Psilocybin Use Soars in the US Since Legalization

, 2025-04-24 11:38:00 Since 2019, the number of people in the United States using psilocybin has gone up sharply, which lines up with when some states began to decriminalize the hallucinogenic chemical found in “magic mushrooms.” Psilocybin use increased across all age groups, with the largest uptick seen in young adults and older adults. With…

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Healthee secures $50M in an oversubscribed Series B round

, 2025-04-24 15:15:00 New York-based Healthee, a healthcare benefits navigation platform, announced an oversubscribed $50 million Series B funding raise led by Key1 Capital.  Existing investors Group11, Fin Capital and Glilot Capital Partners also participated in the round.  The company said in a statement that it did not formally launch the raise but rather was…

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Women’s Health Initiative to receive NIH funding after all

Elizabeth Cooney , 2025-04-25 00:59:00 Elizabeth Cooney is a cardiovascular disease reporter at STAT, covering heart, stroke, and metabolic conditions. On Monday, the groundbreaking Women’s Health Initiative announced that the federal contracts funding the study’s 40 regional centers would end with the fiscal year. But on Thursday a federal official said the Department of Health…

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Global South cities hold key to unlocking health care solutions, studies show

, 2025-04-24 22:30:00 Credit: Unsplash/CC0 Public Domain Most people living in cities in low- and middle-income countries can reach primary care clinics within 30 minutes—yet average quality of care remains poor with clinicians failing to make correct diagnoses or implement appropriate treatments, new studies reveal. The costs of providing services vary significantly and while most…

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Higher Radiation Doses Safe in NSCLC

, 2025-04-24 11:52:00 TOPLINE: Heterogeneous escalation of radiotherapy dose guided by imaging in locally advanced non–small cell lung cancer (NSCLC) does not increase early toxicity, a new trial found. METHODOLOGY: Radiotherapy with concurrent chemotherapy is the standard of care for patients with locally advanced NSCLC, despite curatively intended treatment showing suboptimal locoregional control. Previous phase…

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Advancing Patient & Planet Health Through Proper Healthcare Waste Management

Alex Chapman , 2025-04-24 13:42:00 April is Earth Month – a reminder for organizations to consider their footprint on the planet and their journey to better environmental and community outcomes. Hospitals and health systems can face significant environmental and safety challenges when managing waste created through the course of patient care, diagnosis, and treatment. Waste…

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Ascertain scores $10M for case management assistant platform

, 2025-04-24 17:24:00 Healthcare technology company Ascertain announced it secured $10 million in Series A funding. The round was led by Deerfield Management with participation from Northwell Health. WHAT IT DOES Ascertain is an AI-enabled case management assistant that automates administrative tasks. It helps health systems, payers and independent provider groups simplify operations and lower…

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COVID-19 lowers sperm count and motility, new study confirms

, 2025-04-25 00:05:00 Men who’ve had COVID-19 may face hidden fertility risks. This study uncovers how the virus disrupts sperm health, even months after recovery. Study: COVID-19 infection was associated with poor sperm quality: a cross-sectional and longitudinal clinical observation study. Image Credit: Marko Aliaksandr / Shutterstock.com The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus…

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Predictive Factors Shape Guselkumab Response in Psoriasis

, 2025-04-24 12:00:00 TOPLINE: A new study found that 57.6% of patients with psoriasis achieved super responder status with guselkumab, characterised by complete skin clearance at week 20. Bio-naive status and lower comorbidity rates were associated with superior response, with 85% of super responders maintained Psoriasis Area and Severity Index (PASI) 100 at year 4….

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Trial Data Shows ‘IUD for Men’ Is Effective for 2 Years

Katie Adams , 2025-04-24 20:45:00 Contraline — a trailblazer in the nascent male contraceptive market — released promising new trial data on Thursday showing that the company’s contraceptive hydrogel has demonstrated safety and efficacy in the first two trial participants to reach the two-year mark. In November 2022, Virginia-based Contraline became the first company to…

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An Overview of Breakthrough Cancer Treatments

MNB Guest , 2025-04-24 17:23:00 Cancer continues to be one of the most daunting health challenges to mankind, challenging researchers and physicians to work tirelessly to innovate. From surgeries and aggressive chemotherapy protocols to genomic profiling and immunotherapy, treatment paradigms have dramatically shifted, fundamentally revamping patient experiences and survival rates. In the midst of tremendous…

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Blue Shield of California shared private health data of 4.7M members with Google for years

, 2025-04-24 18:37:00 Healthcare insurer Blue Shield of California has notified 4.7 million individuals of a potential data breach after unknowingly sharing patients’ protected health information with Google since 2021.  “On February 11, 2025, Blue Shield discovered that, between April 2021 and January 2024, Google Analytics was configured in a way that allowed certain member…

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Islet Transplant Shows Long-Term Benefits in T1D

, 2025-04-24 12:00:00 TOPLINE: Islet transplantation offered significant benefits in reducing mortality and other complications in patients with type 1 diabetes (T1D) over a median follow-up duration exceeding 10 years. The procedure’s long-term safety profile revealed no increased risk for cancer despite the use of immunosuppressive therapy. METHODOLOGY: Researchers conducted a retrospective, multicentre cohort study…

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Nourish Lands $70M to Fight Chronic Disease with Nutrition Care

Marissa Plescia , 2025-04-24 21:14:00 Nourish, a nutrition counseling company, announced Wednesday that it raised $70 million in Series B funding for its network of registered dietitians. New York City-based Nourish, which launched three years ago, has more than 3,000 registered dietitians on its platform, all W-2 employees. It connects patients with a chronic condition…

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The Impact of Organized Medical Storage on Patient Safety and Care Quality

MNB Guest , 2025-04-24 17:26:00 Approximately 400,000 hospital in-patients in America are exposed to avoidable harm annually, with more than 200,000 avoidable errors causing death. That is staggering.  These statistics highlight how imperative patient safety is in health facilities. Although all sorts of factors are responsible for causing medical errors, one of which is often…

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Blue Shield of CA shared private health data of 4.7M members with Google for years

, 2025-04-24 18:37:00 Healthcare insurer Blue Shield of California has notified 4.7 million individuals of a potential data breach after unknowingly sharing patients’ protected health information with Google since 2021.  “On February 11, 2025, Blue Shield discovered that, between April 2021 and January 2024, Google Analytics was configured in a way that allowed certain member…

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For colon cancer that no longer responds to treatment, a new drug combination offers hope

, 2025-04-24 19:43:00 Credit: Unsplash/CC0 Public Domain A novel combination therapy offers better outcomes for patients with KRAS G12C metastatic colorectal cancer that have stopped responding to chemotherapy, according to a Phase 3 clinical trial by researchers at City of Hope. In January, the Food and Drug Administration (FDA) approved the combination to treat patients…

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Biomarker Trio Shows Promise for Monitoring CKD

, 2025-04-24 12:00:00 TOPLINE: The choice of renal replacement therapy, along with factors such as dialysis duration and cause and stage of chronic kidney disease (CKD), can affect the levels of renalase, dopamine, and norepinephrine in patients with CKD, highlighting the importance of monitoring these levels for predicting disease progression and the risk for cardiovascular…

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5 Keys to a Successful and Fulfilling Nursing Career

MNB Guest , 2025-04-24 18:45:00 The healthcare sector is one of the fastest-growing sectors. It seems sensible that someone would desire to progress in the nursing field. This is because it is in high demand and offers a stable and rewarding career path.  A nursing career advancement is similar to any other, it requires careful…

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Blue Shield of CA shared health data with Google for years, impacting 4.7M

, 2025-04-24 18:37:00 Healthcare insurer Blue Shield of California has notified 4.7 million individuals of a potential data breach after unknowingly sharing patients’ protected health information with Google since 2021.  “On February 11, 2025, Blue Shield discovered that, between April 2021 and January 2024, Google Analytics was configured in a way that allowed certain member…

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Both low and moderate-high intensity exercise could help fight against Alzheimer’s

, 2025-04-24 17:29:00 Researchers at University of California San Diego and Wake Forest University have found that both low and moderate-high intensity exercise could be valuable tools in the fight against Alzheimer’s. The new research, published as two papers in Alzheimer’s and Dementia: The Journal of the Alzheimer’s Association, describes the results of the EXERT…

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Self-Harm Among US Adolescents: New Data

, 2025-04-24 12:19:00 TOPLINE: Among adolescents, rates of nonfatal self-harm may be higher in older teens, females, and those who are multiracial, according to an analysis of data from hospitals in California. METHODOLOGY: Researchers analyzed hospital discharge data from inpatient and emergency departments in California between 2005 and 2021 to examine the rate of nonfatal…

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Yosi Health joins Elation Health’s Partner Hub

, 2025-04-24 15:51:00 Patient engagement and workflow automation platform Yosi Health announced it has joined Elation Health’s Partner Hub.  Elation Health offers tools for telehealth, patient engagement and an EHR geared toward primary care providers. The aim is to benefit primary care practices by integrating Yosi Health’s digital patient intake, self-scheduling, pre-visit check-ins, two-way text…

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What are the best practices?

Emma Bascom , 2025-04-24 14:31:00 April 24, 2025 4 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process…

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Safeguarding vaccine policy and information in the U.S.

Margaret A. Hamburg and Harvey V. Fineberg , 2025-04-24 15:00:00 Vaccines don’t save lives. Vaccinations do. And every dollar spent on routine immunization in the U.S. is estimated to save $11, not to mention that vaccinations have prevented countless deaths and suffering. Yet U.S. Secretary of Health and Human Services Robert F. Kennedy Jr. has…

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The gambling industry has women in its sights. Why aren’t policymakers paying attention?

, 2025-04-24 15:48:00 Credit: Stefan Coders from Pexels Whatever the code, whatever the season, Australian sports fans are bombarded with gambling ads. Drawing on Australians’ passion, loyalty and pride for sport, the devastating health and social consequences of gambling—including financial stress, homelessness, family violence, and mental health issues—are largely sidelined. Instead, ads continue to normalize…

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