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, 2025-04-26 04:26:00 BioSkryb Genomics and Tecan Group, today introduced a high-throughput single-cell workflow, combining BioSkryb’s 384-well format of the ResolveOME™ Whole Genome and Transcriptome Single-Cell Core Kit with the Uno Single Cell Dispenser™, provided by Tecan. The integrated solution enables parallel high-resolution analysis of hundreds to thousands of individual cells, addressing growing demand for…

, 2025-04-25 11:41:00 Adjunctive use of xanomeline/trospium chloride (Cobenfy) offered no statistically significant benefit over placebo in adults with symptoms of schizophrenia inadequately controlled by an atypical antipsychotic, according to top-line results from the phase 3 ARISE study. However, adjunctive use of the first-in-class antipsychotic did show a numerical improvement compared with treatment with placebo…

Andrew (Drew) Rhoades; Stephanie C. Viguers; Angela Fitch, MD, FACP, FOMA , 2025-04-25 18:30:00 April 25, 2025 1 min watch Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on…

Elaine Chen , 2025-04-25 12:41:00 Novo Nordisk has notched a major legal win against compounding pharmacies that make copies of its diabetes and obesity drug semaglutide, sold under the brand names Ozempic and Wegovy. A federal judge on Thursday ruled against a compounding trade group’s request for a preliminary injunction that would have prevented the…

, 2025-04-25 16:52:00 Microglia (magenta) interacting with T cells (yellow) in the central nervous system of SPG15-deficient mice. Cell nuclei are shown in gray. Credit: Dr. Stumm’s working group/University of Jena Patients with spastic paraplegia type 15 develop movement disorders during adolescence that may ultimately require the use of a wheelchair. In the early stages…

, 2025-04-26 04:45:00 Background and objectives Traditional Chinese medicine (TCM) is widely used in cancer care in China as an integral part of treatment. This study aimed to understand the motivations of cancer patients in China for adopting TCM in their treatment and to examine their communication with oncologists. Gaining insights into these factors can…

, 2025-04-25 12:00:00 TOPLINE: Depression and loneliness predicted memory decline over time in older adults, while memory decline worsened mood symptoms, according to a new study that highlighted a bidirectional link among these variables. METHODOLOGY: Researchers aimed to study longitudinal relationships among immediate memory, depressive symptomatology, and loneliness, while controlling for age and the number…

Stephen I. Feller , 2025-04-25 18:58:00 April 25, 2025 1 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to…

Ed Silverman , 2025-04-25 13:24:00 And so, another working week will soon draw to a close. Not a moment too soon, yes? This is, you may recall, our treasured signal to daydream about weekend plans. Our agenda is still shaping up. We expect to promenade with the official mascots and catch up on our reading, but…

, 2025-04-25 16:54:00 Model of differentiated thyroid cancer (DTC) metastatic progression. Credit: Thyroid® (2025). DOI: 10.1089/thy.2024.0303 Researchers from the Endocrine Tumors group at the Germans Trias i Pujol Research Institute (IGTP), in collaboration with five university hospitals, have conducted the first comprehensive study of DNA methylation patterns in metastatic differentiated thyroid cancer (DTC). Published in…

, 2025-04-26 05:06:00 Researchers from The University of Texas MD Anderson Cancer Center will present promising results from clinical trials in three minisymposia abstracts at the American Association for Cancer Research (AACR) Annual Meeting 2025. Findings include a personalized vaccine combination therapy for colorectal cancer, the use of radiotherapy to avoid the toxicities of systemic…

, 2025-04-25 12:00:00 TOPLINE: Radiofrequency microtenotomy using the Topaz technique led to significant pain reduction, functional improvement, and low complication rates in patients with chronic plantar fasciopathy who were unresponsive to conservative treatments. METHODOLOGY: Researchers conducted a systematic review and meta-analysis of 15 studies involving 1576 patients (mean age, 45-55 years) with chronic plantar fasciopathy…

Nancy Hemphill, ELS, FAAO , 2025-04-25 19:17:00 April 25, 2025 2 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . ” data-action=subscribe> Subscribe We were unable to process your request. Please try…

Ed Silverman , 2025-04-25 15:25:00 Ed Silverman, a senior writer and Pharmalot columnist at STAT, has been covering the pharmaceutical industry for nearly three decades. Amid growing anxiety over tariffs, Vanderbilt University Medical Center has warned its suppliers that any sudden price hikes attributed to the levies will be rejected unless a company can justify…

, 2025-04-25 16:57:00 Credit: AI-generated image Differentiated thyroid cancer patients who receive radioiodine (RAI) treatment after surgery have increased relative survival rates compared to those who do not receive the treatment. According to new research published in the April issue of The Journal of Nuclear Medicine, the clear trend for a higher long-term survival rate…

, 2025-04-26 03:24:00 Even for patients covered by Medicare, annual out-of-pocket costs for lifesaving cancer treatments taken in pill form have often exceeded $10,000-until recently. Thanks to changes in Medicare Part D introduced by the Inflation Reduction Act (IRA) that took effect in 2025, annual out-of-pocket drug costs for all beneficiaries are now capped at…

, 2025-04-25 12:26:00 TOPLINE: Spleen stiffness measurement (SSM) demonstrated strong predictive accuracy for liver decompensation in patients with compensated advanced chronic liver disease (cACLD), with an optimal cutoff of 50 kPa. METHODOLOGY:  Portal hypertension is a key prognostic factor in cACLD. Although hepatic venous pressure gradient measurement is the gold standard for assessing it, noninvasive…

Sara Kellner , 2025-04-25 19:26:00 April 25, 2025 1 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process…

Jonathan Wosen , 2025-04-25 15:36:00 Akeso, a Chinese biotech that made headlines for beating Merck’s Keytruda in a head-to-head trial, won approval in China this week for the therapy, a company spokesperson confirmed to STAT. New data show early hints of the medicine improving patient survival — the gold standard outcome of any cancer study….

, 2025-04-25 16:58:00 by I. Edwards Novavax’s COVID-19 vaccine could soon receive full approval from the U.S. Food and Drug Administration (FDA), the company said Wednesday. The update sent Novavax’s stock up more than 21% in early trading. It also helped ease fears that the decision had been delayed by the Trump Administration, The Associated…

, 2025-04-26 02:12:00 Researchers at University of California San Diego found that cigarette smoking continues to decline across the United States, largely driven by young adults. Their study, published in JAMA Network Open on April 25, 2025, reveals that the states with historically high smoking rates have seen the most dramatic declines. However, smoking cessation…

, 2025-04-25 12:44:00 The National Pharmacy Association (NPA) has stepped back from plans for coordinated action that could have led to high street pharmacies in England limiting their opening hours and cutting services in a dispute over funding.  The decision follows a settlement offer from the government, which the NPA described as a “clear step…

Philip Gioia; Nancy Hemphill, ELS, FAAO , 2025-04-26 01:15:00 LOS ANGELES — Nordic Pharma and Harrow partnered to launch an authorized generic of Maxitrol, Nordic President Philip Gioia said in this Healio Video Perspective from SightLine.Gioia said the neomycin and polymyxin B sulfates and dexamethasone ophthalmic suspension will offer a more cost-effective generic option for…

Associated Press , 2025-04-25 18:36:00 NEW YORK — Luigi Mangione pleaded not guilty Friday to a federal murder charge in the killing of UnitedHealthcare CEO Brian Thompson as prosecutors formally declared their intent to seek the death penalty and the judge warned the Justice Department to stop making public comments that could spoil the case. Mangione, 26,…

, 2025-04-25 17:00:00 The U.S. Preventive Services Task Force (USPSTF) recommends counseling for women at increased risk for perinatal depression (PND). This recommendation forms the basis of a draft recommendation statement published online April 22. Researchers from the USPSTF reviewed the benefits and harms of primary care-relevant interventions to prevent PND to update the 2019…

, 2025-04-25 18:46:00 A rare cell type in the lungs is essential to survival from the COVID-19 virus, a new study shows. Experiments in mice infected with the SARS-CoV-2 virus revealed that the immune cell class in question, called nerve and airway-associated interstitial macrophages, or NAMs, may keep the human immune system’s initial counterattack on…

, 2025-04-25 12:54:00 TOPLINE: Children who received multiple antibiotic courses between birth and 2 years of age had a higher risk of developing asthma, food allergies, allergic rhinitis, and intellectual disability, according to a new study.  METHODOLOGY: Researchers analyzed data from a large nationally representative population to examine the associations between antibiotic exposure patterns within…

Anthony DeFino , 2025-04-25 22:02:00 April 25, 2025 2 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process…

Tara Bannow , 2025-04-25 21:20:00 Tara Bannow covers hospitals, providers, and insurers. You can reach Tara on Signal at tarabannow.70. Sutter Health has agreed to pay about $230 million to settle a federal class-action lawsuit accusing the Northern California health system of anticompetitive behavior that raised costs for millions of Californians.  Both sides agreed to…

, 2025-04-25 17:01:00 Six in 10 women believe they will hit menopause in their 40s, according to survey results released April 8 by The Ohio State University Wexner Medical Center in Columbus. The survey (web and telephone) was conducted in two waves from Feb. 7 to 10, 2025, and Feb. 21 to 24, 2025, with…

, 2025-04-25 18:59:00 Researchers in South Korea have developed an organoid disease model and non-destructive stiffness analysis technology for evaluating the efficacy of new drugs for fatty liver disease. The research team led by Dr. Hyunwoo Kim and Dr. Myungae Bae at the Korea Research Institute of Chemical Technology (KRICT) has developed the nano-probe-based quantitative stiffness…

, 2025-04-25 13:25:00 The National Institute for Health and Care Excellence (NICE) has recommended ribociclib (Kisqali, Novartis) as an adjuvant treatment for early breast cancer in patients at high risk of recurrence.  The recommendation applies to patients in England with HR-positive, HER2-negative early breast cancer. This is the most common breast cancer subtype, accounting for…

Luidgi Faubert , 2025-04-25 14:12:00 Health insurance is rapidly evolving, requiring providers and employers to be adaptable. If you have employees, you must consider what they need from their coverage while considering costs. Here’s a guide on 2025 developments in health care benefits.  What Are the Major Trends Emerging in Health Care Benefits? Understanding recent…

Andrew (Drew) Rhoades; Lydia Alexander, MD , 2025-04-25 22:31:00 April 25, 2025 6 min watch Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . ” data-action=subscribe> Subscribe We were unable to process your request….

Elizabeth Cooney , 2025-04-25 21:43:00 Vasan Ramachandran is baffled. A cardiologist and veteran of the famed Framingham Heart Study, he is struggling to understand why a similar study he brought to life in 10 rural counties across four Southern states is facing elimination. The RURAL Cohort Study, set in motion six years ago, was nearing…

, 2025-04-25 17:03:00 More than one in seven adults reported carrying medical debt in 2023, and of these, one in three forwent mental health care in the subsequent year, according to a research letter published online April 18 in JAMA Health Forum. Kyle J. Moon, from the Johns Hopkins Bloomberg School of Public Health in…

, 2025-04-25 19:11:00 According to the World Health Organization (WHO), over 22% of the global population smokes, with more than 9 million smoking-related deaths reported annually. Effective treatments to alleviate nicotine withdrawal symptoms caused by smoking cessation are essential for successful smoking cessation. Currently, approved treatments for nicotine withdrawal include Bupropion and Varenicline, but there…

, 2025-04-25 14:56:00 The US Food and Drug Administration (FDA) has approved penpulimab-kcqx (Akeso Biopharma) in combination with cisplatin or carboplatin and gemcitabine as first-line treatment for adults with certain types of nasopharyngeal carcinoma (NPC), and as a single agent for certain patients with NPC disease progression on or after other treatments. Specifically, the novel…

Frank Vinluan , 2025-04-25 17:22:00 Caribou Biosciences’ 2025 outlook aimed for key trial readouts for two cancer cell therapies in the first half of the year and the start of clinical testing in an autoimmune disease. The CRISPR biotech is now shelving the autoimmune program and slashing staff in order to focus its resources and…

Michael McHale , 2025-04-25 07:30:00 Development means that Tallaght laboratory ‘future-proofed’ for expected increases in demand The installation of cutting-edge sample testing technology is set to significantly increase a Dublin hospital’s capacity to test patient samples. The Cellular Pathology Laboratory at Tallaght University Hospital (TUH) recently introduced the Axlab AS-410 M, auto slide preparation system….

, 2025-04-25 17:29:00 Indianapolis-based pharmaceutical behemoth Eli Lilly has filed lawsuits against four compounders claiming that they sold unapproved products that contain tirzepatide, a key ingredient in the company’s weight-loss and diabetes drugs, including top-seller Mounjaro. The lawsuits against Mochi Health, Fella Health and Delilah, and Henry Meds were filed in the U.S. District Court Northern…

Moira Mahoney , 2025-04-25 20:21:00 April 25, 2025 2 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process…

Jonathan Wosen , 2025-04-25 19:29:00 The National Institutes of Health on Friday announced six acting directors to run institutes, many to fill vacancies created by the ouster of predecessors as part of the Trump administration’s unprecedented reshaping of federal scientific agencies. In an email from the NIH Executive Secretariat obtained by STAT, the agency said…

, 2025-04-25 18:00:00 Skin-related fibroblasts with nuclei stained green and f-actin stained red. Credit: Jude Phillip, Johns Hopkins University Senescent skin cells, often referred to as zombie cells because they have outlived their usefulness without ever quite dying, have existed in the human body as a seeming paradox, causing inflammation and promoting diseases while also…

, 2025-04-25 19:21:00 It’s no secret that our waistlines often expand in middle-age, but the problem isn’t strictly cosmetic. Belly fat accelerates aging and slows down metabolism, increasing our risk for developing diabetes, heart problems and other chronic diseases. Exactly how age transforms a six pack into a softer stomach, however, is murky. Now preclinical…

, 2025-04-25 15:30:00 The presence of five key proteins in the blood was strongly associated with the development of metabolic dysfunction-associated steatotic liver disease (MASLD) as much as 16 years before symptoms appeared, new research showed. “This represents the first high-performance, ultra-early (16 years) predictive model for MASLD,” said first author Shiyi Yu, MD, resident…

Katie Adams , 2025-04-25 18:06:00 Orchestra BioMed’s hypertension treatment is the latest medical device to earn the FDA’s breakthrough designation. The device is an atrio-ventricular interval modulation therapy, meaning it uses a pacing algorithm to actively lower blood pressure. By granting Orchestra’s product a breakthrough device status, the FDA is putting it on a fast…

Michael McHale , 2025-04-25 07:30:00 Open letter to Government opposes plans to re-examine labelling measures which are due to begin in May 2026 The planned introduction of health information labelling on alcohol should not be ‘derailed or delayed’ by industry lobbying, an open letter signed by more than 75 health advocates has said. The letter…

, 2025-04-25 17:51:00 ECG diagnostics software platform AccurKardia and cardiac medical technology company HeartBeam are joining forces to make AccurKardia’s ECG analysis software available on HeartBeam’s devices.  HeartBeam’s cable-free, 12-lead ECG system captures electrical signals from the heart from three directions to assess arrhythmias.  The platform is designed for portable devices so physicians can identify…

Mike Dennison , 2025-04-25 18:30:00 Hospitals have spent years amassing political influence at the federal and state levels. According to the nonprofit OpenSecrets, hospitals and nursing homes’ federal lobbying spending rose from $35 million in 2000 to more than $133 million last year, a 280% increase.  They recently had a unique opportunity to flex some…