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Noninvasive prenatal testing identifies twice as many Down syndrome cases as second-trimester serum screening

, 2025-05-18 18:30:00 Credit: BGI Genomics A novel study has analyzed the cost-effectiveness of different Down syndrome (DS) screening strategies. The result confirms that noninvasive prenatal testing (NIPT) outperforms second-trimester serum screening (STSS) in accuracy and cost-effectiveness, as NIPT identifies twice as many DS cases as STSS. The study was conducted by researchers from Changsha…

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Large-scale analysis reveals distinct genetic patterns in veterans with metastatic prostate cancer

, 2025-05-18 17:19:00 Credit: Pixabay/CC0 Public Domain In the largest clinical genomic profiling study of non-Hispanic Black men with metastatic prostate cancer to date, researchers from Moffitt Cancer Center, University of Pennsylvania, University of California Los Angeles and the Veterans Affairs (VA) National Precision Oncology Program found key differences in tumor biology between non-Hispanic Black…

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Waitlist deaths drop under new lung transplant allocation system

, 2025-05-18 16:20:00 Credit: Pixabay/CC0 Public Domain Two years ago, the United Network for Organ Sharing implemented new allocation guidelines for lung transplants that prioritize medical urgency. Now new research, published at the 2025 ATS International Conference and in the American Journal of Respiratory and Critical Care Medicine, shows that waitlist outcomes significantly improved under…

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Methotrexate as effective as prednisone in pulmonary sarcoidosis, research finds

, 2025-05-18 16:20:00 Credit: Pixabay/CC0 Public Domain Prednisone is recommended as the first-line treatment for pulmonary sarcoidosis, but this steroid causes a number of unwanted side effects. Now new research, published at the ATS 2025 International Conference and in the American Journal of Respiratory and Critical Care Medicine, finds that methotrexate provides a comparable alternative….

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Wearable sensor could be used to monitor obstructive sleep apnea treatment response

, 2025-05-18 16:20:00 System overview. Credit: American Journal of Respiratory and Critical Care Medicine (2025). DOI: 10.1164/ajrccm.2025.211.Abstracts.A1059 A wearable pulse oximeter and connected software platform show promise for monitoring obstructive sleep apnea (OSA) and other sleep-related breathing diseases, according to research presented at the ATS 2025 International Conference. The findings were also published in the…

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Why WeightWatchers Filed for Bankruptcy

Marissa Plescia , 2025-05-18 14:43:00 WeightWatchers has long been a household name, boosted by celebrity endorsements from Oprah Winfrey and Jennifer Hudson. Jean Nidetch founded the New York City company in her apartment in the early 1960s, and grew it to serve more than 4 million members worldwide. From those humble roots, the company evolved…

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Glial cells may play key role in managing sleep and metabolism, fruit fly study suggests

, 2025-05-18 13:40:00 Behavior in freely moving flies and long-term calcium imaging in EG during behavior. Credit: Nature Neuroscience (2025). DOI: 10.1038/s41593-025-01942-1 Homeostasis is the ability of living organisms to maintain stable internal conditions, such as temperature, hydration and blood sugar levels, irrespective of any changes in their surroundings. Homeostatic mechanisms also regulate behaviors that…

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Clinical Trials Have a Research Site Demand and Supply Crisis. Here is How to Solve it

Bree Burks , 2025-05-18 13:45:00 Clinical research sites face an information challenge that hinders efficiency and collaboration. As trial complexity increases, the multiple logins, devices, and spreadsheets site staff use to execute studies create siloed workstreams. In addition, each sponsor has its preferred software solutions for every trial, making collecting, accessing, and sharing data a…

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High times for German cannabis firm amid medical boom

, 2025-05-18 10:05:00 Medical cannabis has been a boon for the Berlin-based company whose website slogan says ‘we love cannabis’ and whose Frankfurt Stock Exchange ticker symbol is ‘HIGH’ At an undisclosed site in Germany’s Bavaria state, pharmaceutical CEO Philip Schetter opens a 75-centimeter (30-inch) thick steel door that secures his wares: vast amounts of…

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Matching mindfulness methods to anxiety symptoms may boost mental well-being, study finds

, 2025-05-18 10:12:00 Credit: Kelvin Valerio from Pexels If you’re anxious about work, finances, the state of the world, or anything else, you might try a moment of mindfulness. Paying close attention to the present moment without judgment—the basic idea behind all mindfulness techniques—can help calm anxiety and improve focus, said Resh Gupta, a postdoctoral…

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FDA approves Novavax Covid vaccine after delay

Helen Branswell , 2025-05-18 00:12:00 Helen Branswell covers issues broadly related to infectious diseases, including outbreaks, preparedness, research, and vaccine development. Follow her on Mastodon and Bluesky. You can reach Helen on Signal at hbranswell.01. The Food and Drug Administration has finally approved Novavax’s Covid-19 vaccine, but in doing so has placed restrictions on it…

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New discovery about how acetaminophen works could improve understanding about pain relievers

, 2025-05-16 15:41:00 Credit: Cell Reports Medicine (2025). DOI: 10.1016/j.xcrm.2025.102139 A new study from Indiana University scientists may aid the pharmaceutical industry in better understanding a popular over-the-counter pain reliever: Tylenol. Michaela Dvorakova, a postdoctoral researcher at IU’s Gill Institute for Neuroscience and the College of Arts and Sciences’ Department of Psychological and Brain Sciences,…

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Study shows infant immune systems respond differently to severe COVID-19

, 2025-05-16 15:42:00 a) Study design. b) Viral load quantification across the three pCoV groups. Credit: Nature Communications (2025). DOI: 10.1038/s41467-025-59411-z Infants hospitalized with severe COVID-19 have significantly different immune responses than adults or older children. The finding comes from scientists at St. Jude Children’s Research Hospital, The Jackson Laboratory for Genomic Medicine, Weill Cornell…

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Lithuanian scientists present a smart system for integrated post-stroke monitoring

, 2025-05-16 15:47:00 A smart system for integrated post-stroke monitoring developed by Lithuanian scientists. Credit: Kaunas University of Technology Stroke is one of the leading causes of long-term disability worldwide. According to the World Health Organization, approximately 15 million people suffer a stroke each year. Of these, 5 million die and another 5 million are…

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Improved health has not boosted workforce prospects

, 2025-05-16 15:57:00 Advances in medical technology have led to significant health improvements in people with diabetes, but workforce participation has not improved for this population. Credit: JAMA Health Forum (2025). DOI: 10.1001/jamahealthforum.2025.0756 Advances in medical technology over the last 30 years have made it easier to detect and treat diabetes, leading to significant health…

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Genetic study identifies modifiable factors

, 2025-05-16 15:57:00 Multiresponse Mendelian randomization (MR2) estimates the causal associations of modifiable factors and coexisting disorders with irritable bowel syndrome (IBS). Credit: eGastroenterology (2025). DOI: 10.1136/egastro-2024-100126 Irritable bowel syndrome (IBS) is a prevalent and debilitating gastrointestinal disorder affecting approximately 5%–10% of the global population. Characterized by abdominal pain, bloating, and altered bowel habits, IBS…

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Sweat and saliva testing as an alternative to blood sampling

, 2025-05-16 16:10:00 Credit: Bart van Overbeeke What if we could monitor patients in the future without taking blood samples every time? TU/e researcher Sophie Adelaars investigated a promising alternative: measuring biomarkers in sweat and saliva. In May 2025, she defended her thesis at the Department of Electrical Engineering. Adelaars conducted her research in collaboration…

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From osteoporosis medication to a possible treatment for breast cancer

, 2025-05-16 16:14:00 Impact of denosumab on stromal tumor infiltrating lymphocytes. Credit: Breast Cancer Research (2025). DOI: 10.1186/s13058-025-01996-w Science and society collaboration is essential for scientific progress, especially in the health and biomedical fields where basic researchers, clinicians and patients are involved, as shown by the initial results of D-BIOMARK. This clinical trial against breast…

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Movement disorders tremor and myoclonus can be well distinguished using machine learning

, 2025-05-16 16:25:00 Schematic overview of the study design. A) Measurements and sensor placement. B) Data preprocessing. C) Validation, machine learning, and evaluation. Credit: Computers in Biology and Medicine (2025). DOI: 10.1016/j.compbiomed.2025.110180 In a pioneering study from the Expertise Center for Movement Disorders in Groningen, machine learning, a core area of artificial intelligence (AI), was…

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Genetic ancestry and parental smoking linked to new genetic changes in children

, 2025-05-17 18:19:00 Credit: Pixabay/CC0 Public Domain Ancestry and lifestyle choices of parents may affect the rate and type of new genetic changes that arise in their children, new research has found. Published in Nature Communications, researchers from the Wellcome Sanger Institute, the University of Cambridge and their collaborators analyzed whole-genome sequence data from 10,000…

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Trial Scorecard: FRESH-UP

Scott Buzby , 2025-05-16 14:20:00 Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process your request. Please try again later….

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Branched-chain amino acids supplements may harm male bodybuilders’ fertility

, 2025-05-16 16:27:00 Credit: Victor Freitas from Pexels A new study published in Zygote reveals that common over-the-counter supplements popular with male bodybuilders and athletes may impact their fertility. This study comes amid a global decline in male fertility. In this study, branched-chain amino acids (BCAAs) clearly impacted the reproductive function of male mice, causing…

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Dopamine and noradrenaline linked to hippocampal activation during light exercise

, 2025-05-17 16:30:00 Schematic diagram showing possible circuit mechanism for light-exercise-induced dorsal hippocampal activation. Credit: The FASEB Journal (2024). DOI: 10.1096/fj.202400418RRR Researchers at the University of Tsukuba investigated whether monoamine neurotransmitters, such as dopamine, are involved in hippocampal activation even during light exercise. Dopamine secreted from the ventral tegmental area of the brainstem and noradrenaline…

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Atopic Dermatitis Linked to Higher Odds of NMSC

, 2025-05-16 11:26:00 SAN DIEGO — Patients with atopic dermatitis (AD) are at a significantly higher risk for nonmelanoma skin cancer (NMSC), although the overall risk remains low, a new retrospective database study found. Compared with patients without AD, the odds of NMSC in patients with AD were 1.53 times higher in an adjusted analysis…

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Trial Scorecard: SOUL

Scott Buzby , 2025-05-16 14:29:00 Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process your request. Please try again later….

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Iron deficiency anemia found to significantly increase ischemic stroke risk in young adults

, 2025-05-16 16:28:00 Credit: Pixabay/CC0 Public Domain Findings from a recent study suggest iron deficiency anemia (IDA) independently and significantly increases the odds of ischemic stroke in young adults. The research is published in the journal eJHaem. IDA is the most common form of anemia globally. It results from iron deficiency, when there are insufficient…

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Infection Patterns Matter in Selecting Arthritis Therapies

, 2025-05-16 11:49:00 MANCHESTER, England — The risks for infection are broadly similar regardless of the biologic or targeted synthetic disease-modifying drug used to treat inflammatory arthritis, but different patterns of infection do exist across these advanced therapies, delegates were told at the recent British Society for Rheumatology (BSR) 2025 Annual Meeting. “There are so…

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Trial Scorecard: WARRIOR

Scott Buzby , 2025-05-16 14:36:00 Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . ” data-action=subscribe> Subscribe We were unable to process your request. Please try again later. If you continue to have this…

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Trump moves to terminate hundreds of grants to Harvard

Chris Serres and Kay Lazar — Boston Globe , 2025-05-17 15:22:00 In yet another escalation of its fight against higher education, the Trump administration has moved to terminate hundreds of research grants at Harvard University and its medical school, imperiling dozens of research projects and potentially upending the futures of young scientists. Harvard researchers studying cancer, infectious…

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