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Psychology researchers unravel phobic disorders using one not-so-itsy-bitsy spider

, 2025-04-15 12:38:00 Credit: Northern Arizona University From needles, snakes and airplanes to test-taking, speech-making and germs, sources of all-encompassing panic can make pushing through daily life feel like more trouble than it’s worth. The pounding heartbeats, looming dread and debilitating tremors can lead many with phobias and anxiety disorders to seek methods of treatment….

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Do disasters delay early cancer diagnoses?

, 2025-04-15 11:58:00 Rates of colorectal cancer (CRC) diagnoses dropped during and shortly after Hurricanes Irma and Maria and the COVID-19 pandemic in Puerto Rico, according to a recent analysis. However, late-stage diagnoses eventually exceeded expectations, suggesting that limited access to cancer screening services due to these disasters likely hindered timely CRC diagnoses. The findings…

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Acute Myocarditis Riskier Than Unexplained Chest Pain

, 2025-04-15 12:00:00 TOPLINE:  Despite being younger and having fewer comorbidities, patients with acute myocarditis (AM) had a significantly higher risk for 30-day and long-term mortality than those with unexplained chest pain. METHODOLOGY:  The accurate differentiation of AM from unexplained chest pain is a significant clinical challenge. Researchers conducted a retrospective analysis of data from…

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Fake Ozempic Found in US Drug Supply Chain

, 2025-04-15 10:29:00 Amid the soaring demand for GLP-1 drugs used to treat diabetes and support weight loss, the U.S. Food and Drug Administration (FDA) has issued an urgent warning for consumers using Ozempic. The agency is urging users to carefully inspect their medication labels after discovering that hundreds of counterfeit Ozempic injections have entered…

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LOL: April 15, 2025

Dr Leslie O’Looney , 2025-04-15 07:30:00 Welcome to this week’s issue of The Week in Medicine – a round-up of all the happenings in the world of Irish medicine The Rural, Island and Dispensing Doctors will be having their annual general meeting in the Hodson Hotel in Athlone this year on June 7. They are…

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El temor a la deportación agrava los problemas de salud mental que enfrentan los trabajadores de los centros turísticos de Colorado

Natalie Skowlund , 2025-04-15 09:01:00 SILVERTHORNE, Colorado. — Cuando Adolfo Román García-Ramírez camina a casa por la noche después de su turno en un mercado en este pueblo montañoso del centro de Colorado, a veces se acuerda de su infancia en Nicaragua. Los adultos, recuerda, asustaban a los niños con cuentos de la “Mona Bruja”….

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Single-cell profiling methods compared for gut biopsy analysis

, 2025-04-15 09:39:00 Credit: Cellular and Molecular Gastroenterology and Hepatology (2025). DOI: 10.1016/j.jcmgh.2025.101503 Research on gastrointestinal diseases, especially cancer, has mainly focused on epithelial cells, which line the surfaces of organs, are important for various functions, and are believed to be the cells that go awry to cause these diseases. However, studying these cells using…

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The future of lab science

, 2025-04-15 08:25:00 London Lab Live 2025 will make its debut on 14–15 May 2025 at ExCeL London, offering a major new platform for professionals across the laboratory sector. From pharmaceuticals and biotech to food and beverage, chemicals, and academia, the event is set to become the UK’s central meeting point for scientific innovation and…

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JAK Inhibitors Offer Some Improvement for Pediatric Uveitis

, 2025-04-15 09:43:00 TOPLINE: Janus kinase (JAK) inhibitors led to improvement of uveitis in approximately half of pediatric patients previously treated with disease-modifying antirheumatic drugs (DMARDs) in a case series. METHODOLOGY: The researchers reported a case series from five US and Italian centers on patients under 21 years old who were treated with at least…

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You might be interested in…Hypertension

Dr Ray O’Connor , 2025-04-15 07:30:00 Dr Ray O’Connor takes a look at the latest clinical articles on the subject of hypertension Hypertension (Part 1)Hypertension can be effectively treated with antihypertensive medication, which has been proven to lower the risk of stroke and cardiovascular diseases across all age groups. Even in patients older than 80…

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NIH, FDA, autism, excessive sleepiness

Theresa Gaffney , 2025-04-14 13:07:00 Get your daily dose of health and medicine every weekday with STAT’s free newsletter Morning Rounds. Sign up here. Good morning. For those who were curious, our turkey friend at STAT headquarters last week was indeed a wild turkey, not a turkey vulture. A number of images from different angles, checked with…

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Heart valve abnormality is associated with malignant arrhythmias, study reveals

, 2025-04-15 06:00:00 Credit: Pixabay/CC0 Public Domain People with a certain heart valve abnormality are at increased risk of severe heart rhythm disorders, even after successful valve surgery. This is according to a new study, “Mitral annular disjunction and mitral valve prolapse: long-term risk of ventricular arrhythmias after surgery” from Karolinska Institutet and Karolinska University…

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The EU Action Plan must step up European-national cooperation

, 2025-04-15 05:53:00 A high-level conference convened in Warsaw under the auspices of the Polish Presidency of the Council of the European Union highlighted the importance of adopting a comprehensive Europe-wide policy framework on rare diseases. Image Credit: European Economic and Social Committee (EESC) The European Union needs a European Action Plan on Rare Diseases…

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EU Emergency Plan Misses Local Healthcare

, 2025-04-15 05:10:00 The European Union (EU) has introduced its “Preparedness Union Strategy,” designed to strengthen resilience in emergencies such as natural disasters, pandemics, cyberattacks, and armed conflict. This initiative is inspired by models already adopted in Scandinavian countries, such as Finland, Sweden, and Denmark, which have implemented similar measures to prepare their populations for…

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Can I work while having IVF?

Abi Rimmer , 2025-04-14 09:21:00 Going through fertility treatment can be physically and mentally exhausting, especially when working at the same time, but there are ways you can ease the strain, Abi Rimmer hears Be kind to yourself Divpreet Sacha, general practice specialty registrar, Birmingham and Solihull, says, “In vitro fertilisation (IVF) is becoming increasingly…

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Scientists urge mattress manufacturers to act

, 2025-04-15 04:10:00 Research suggests children may breathe and absorb plasticizers called phthalates, flame retardants, and other harmful chemicals from their mattresses while they sleep. Credit: University of Toronto Babies and young children may breathe and absorb plasticizers called phthalates, flame retardants, and other harmful chemicals from their mattresses while they sleep, according to a…

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Lithium shifts circadian rhythms early in bipolar disorder and may offer clues to treatment response

, 2025-04-15 02:01:00 Can lithium’s effect on daily activity patterns reveal who will benefit from treatment? A six-week trial finds circadian shifts emerge early, before mood improves, hinting at a biological clue to lithium response in bipolar disorder. Study: Effect of lithium on circadian activity level and flexibility in patients with bipolar disorder: results from…

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Cancer Drug Use Declines After Negative Confirmatory Trials

, 2025-04-15 04:05:00 TOPLINE: The use of cancer drugs with withdrawn US Food and Drug Administration (FDA) accelerated approval indications declined significantly after publication of negative confirmatory trials, despite the drugs remaining available for off-label use, a cohort study found. METHODOLOGY: The FDA’s accelerated approval program allows drugs for serious conditions to enter the market…

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Health Execs Criticize Trump Administration for Not Expanding Coverage of Obesity Drugs

Marissa Plescia , 2025-04-08 21:57:00 Late last week, the Trump administration’s CMS announced that it is not finalizing a provision proposed by the Biden administration that would expand coverage of anti-obesity drugs under Medicare and Medicaid. Currently, Medicare and Medicaid are required to cover GLP-1s like Ozempic and Wegovy for conditions like diabetes, but Medicare…

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Innovative solutions are needed to overcome implementation barriers to using reporting guidelines

Gary S Collins , 2025-04-14 22:00:00 Gary S Collins, professor of medical statistics 1Centre for Statistics in Medicine, UK EQUATOR Centre, Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences, University of Oxford, Oxford, UK gary.collins{at}csm.ox.ac.uk (or @GSCollins on X and @gscollins.bsky.social on Bluesky) Reporting guidelines have become an essential instrument of scientific integrity. We need…

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Charting natural history of pediatric patients with SCN8A-related disorders may lead to clinical trials

, 2025-04-14 20:55:00 Credit: Pixabay/CC0 Public Domain Researchers from the Epilepsy Neurogenetics Initiative (ENGIN) at Children’s Hospital of Philadelphia (CHOP) have completed a comprehensive natural history study of SCN8A-related disorders, which represent a spectrum of neurological symptoms. The study, using retrospective clinical information analyzed through novel data analysis methods, revealed a range of seizure types…

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Digital lifestyle program cuts diabetes risk by 46% in prediabetics, study of 130k+ adults reveals

, 2025-04-15 02:38:00 Could a 45-minute weekly digital coach be the key to reversing diabetes? New study of 130k+ adults shows dramatic risk reduction and remission rates, without pills or extreme diets. Study: Lifestyle Modification in Prediabetes and Diabetes: A Large Population Analysis. Image Credit: RSplaneta / Shutterstock In a recent article published in the journal Nutrients,…

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Mood Stabilizers Show Protective Effects Against Suicide

, 2025-04-14 13:01:00 TOPLINE: Recent lithium and valproate use was associated with a 34%-46% lower risk for suicide in patients with schizophrenia or bipolar disorder (BD), investigators leading a large cohort study reported. METHODOLOGY: In a retrospective cohort study, data were analyzed from the National Health Information Database in South Korea. The study included more…

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Attorneys general want Congress to prohibit PBMs from owning pharmacies

Ed Silverman , 2025-04-15 00:03:00 Dozens of state attorneys general are urging Congress to pass a law prohibiting pharmacy benefit managers from simultaneously owning pharmacies, arguing such a move would boost competition and create more affordable prescription drug prices for Americans. Their concern is these arrangements create conflicts of interest that allow pharmacy benefits managers…

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The legacy of CONSORT and Douglas G Altman

Kenneth F Schulz, David Moher , 2025-04-14 22:00:00 Kenneth F Schulz, adjunct clinical professor1, David Moher, senior scientist2 1Department of Obstetrics and Gynecology, School of Medicine, University of North Carolina at Chapel Hill, NC, USA 2Centre for Journalology, Methodological and Implementation Research Program, Ottawa Hospital Research Institute Correspondence to: kfschulz{at}ad.unc.edu Kenneth F Schulz and David…

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Blood test detects Parkinson’s years before symptoms appear using RNA markers

, 2025-04-15 00:42:00 Scientists have developed a fast, non-invasive blood test that can detect Parkinson’s disease before tremors begin. By measuring RNA fragments that reflect brain pathology, the test offers new hope for early diagnosis and targeted intervention. Study: Pre-symptomatic Parkinson’s disease blood test quantifying repetitive sequence motifs in transfer RNA fragments. Image Credit: Kateryna Kon /…

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Canada, with court order, advances an antitrust probe into Express Scripts

Ed Silverman , 2025-04-14 17:05:00 Canadian officials have obtained a court order that requires Express Scripts to produce documents in connection with an investigation into whether the pharmacy benefits manager violated antitrust laws. The Competition Bureau is examining whether the company forced or induced Canadians to use its own pharmacies. Express Scripts operates four mail-order…

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CONSORT 2025 explanation and elaboration: updated guideline for reporting randomised trials

Sally Hopewell, An–Wen Chan, Gary S Collins, Asbȷorn Hrobȷartsson, David Moher, Kenneth F Schulz, Ruth Tunn, Rakesh Aggarwal, Michael Berkwits, Jesse A Berlin, Nita Bhandari, Nancy J Butcher, Marion K Campbell, Runcie C W Chidebe, Diana Elbourne, Andrew Farmer, Dean A Fergusson, Robert M Golub, Steven N Goodman, Tammy C Hoffmann, John P A Ioannidis,…

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Analysis reveals one firearm injury was treated every 30 minutes in emergency departments in 10 jurisdictions

, 2025-04-14 21:00:00 Credit: Unsplash/CC0 Public Domain A cross-sectional analysis of firearm injury-related emergency department (ED) visits found that between 2018 and 2023, there was approximately one firearm injury ED visit every 30 minutes in the 10 jurisdictions studied. The analysis also found that rates of firearm-related ED visits were often highest during evenings, weekends,…

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FDA OKs Vyvgart Hytrulo Prefilled Syringe for gMG, CIDP

, 2025-04-14 14:35:00 The US Food and Drug Administration (FDA) has approved a prefilled syringe for self-injection of efgartigimod alfa and hyaluronidase-qvfc (Vyvgart Hytrulo, argenx) in the treatment of adults with generalized myasthenia gravis (gMG) who are anti-acetylcholine receptor antibody positive and adults with chronic inflammatory demyelinating polyneuropathy (CIDP).  The prefilled syringe will be available as…

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