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The diagnosis explosion: an important new book tries to understand what’s happening

Richard Smith , 2025-04-16 14:11:00 Richard Smith, chair UK Health Alliance on Climate Change Darcie is a woman in her early 20s with migraine, hypermobile Ehlers-Danlos syndrome, anorexia, irritable bowel syndrome, postural orthostatic tachycardia syndrome, autism, attention deficit/hyperactivity disorder (ADHD), depression, and anxiety. She was referred to the neurologist Suzanne O’Sullivan because she developed seizures….

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Mosquito-borne chikungunya kills six in La Reunion

, 2025-04-16 19:56:00 Credit: Ravi Kant from Pexels A disabling mosquito-borne disease called chikungunya has killed six people in the French Indian Ocean island of La Reunion but the outbreak appears to be easing, authorities said on Wednesday. The island located east of Madagascar has been hit by the epidemic since last August, with one…

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IL-5 Inhibitors May Be Steroid Alternative For Rx of DRESS

, 2025-04-16 15:00:00 TOPLINE: A retrospective case series found that treatment with an interleukin (IL)-5 inhibitor reduced eosinophil levels and improved clinical outcomes in patients with drug reaction with eosinophilia and systemic symptoms (DRESS), with no adverse events or long-term autoimmune sequelae. METHODOLOGY: Researchers conducted a retrospective case series of 16 patients treated with IL-5…

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Mark Cuban Cost Plus Drug Company partners with specialty pharmaceutical distributor

, 2025-04-16 18:13:00 Specialty pharmaceutical distributor Morris & Dickson is partnering with Mark Cuban’s Cost Plus Drug Company (MCCPDC) and the Cost Plus Marketplace to ensure access to vital injectable medications. MCCPDC offers consumers a broad range of low-cost prescription and over-the-counter drugs from National Association of Boards of Pharmacy (NABP) accredited suppliers.  The Cost…

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New human ‘multi-zonal’ liver organoids improve injury survival in rodents

, 2025-04-16 16:52:00 Engineering hiPS cell-derived mZ-HLOs. Credit: Nature (2025). DOI: 10.1038/s41586-025-08850-1 One reason why our livers excel at clearing waste from our blood system is that the organ functions according to three key “zones” that perform specific major tasks. So, if scientists hope to create self-growing patches of liver organoid tissue that could help…

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New PCSK9 Gets Cholesterol to Target if Statins Can’t

, 2025-04-16 16:25:00 An investigational drug, currently known as AZD0780, lowers low-density-lipoprotein cholesterol (LDL-C) to target levels in most patients whose cholesterol is still over target despite statin therapy, results from the phase 2b PURSUIT trial show. AZD0780 inhibits PCSK9, a protein that regulates cholesterol metabolism. Inhibition of this protein has proven useful in lowering…

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Healthcare’s Robotic Renaissance: Meeting Future Demands

Winston Leung , 2025-04-16 13:45:00 Healthcare systems are grappling with immense social and economic pressures, including increasing worker burnout rates, an aging population requiring more attentive care, and severe staffing shortages. This challenging landscape was not only evident during the Covid-19 pandemic but also highlights the longing need for support to stifle this harsh reality….

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Parts of new Mental Health Bill ‘unworkable’ and would ‘undermine’ patients’ right to timely treatment

Michael McHale , 2025-04-16 13:16:00 Legal processes outlined in Bill could lead to ‘barriers to care and spiralling legal costs,’ consultants’ group warns Parts of the new Mental Health Bill are ‘unworkable’ and would undermine patients’ right to timely treatment if enacted, the Irish Hospital Consultants Association (IHCA) has said. While welcoming the Bill, a…

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A step forward for stem cells and Parkinson’s disease

Paul Knoepfler , 2025-04-16 15:00:00 Welcome to Lab Dish, a new First Opinion column on regenerative medicine from Paul Knoepfler. I’m upbeat about cell therapy development for Parkinson’s disease, but it has been a marathon. Now two new clinical trial papers published Wednesday in Nature on stem cell-based therapies for Parkinson’s are another step forward….

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Immune system proteins involved in severe parasitic disease identified

, 2025-04-16 14:27:00 Gsdmd deficiency reduces myeloid cell recruitment to the liver during schistosome infection. Credit: PLOS Pathogens (2025). DOI: 10.1371/journal.ppat.1012108 New insights into the mechanisms that cause more severe cases of schistosomiasis—a disease caused by parasitic worms and second only to malaria in terms of potential harm—have been revealed by researchers at Penn State….

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Computer-Aided Colonoscopy Not Ready for Prime Time

, 2025-04-16 13:37:00 An American Gastroenterological Association (AGA) multidisciplinary panel has reached the conclusion that no recommendation can be made for or against the use of computer-aided detection (CADe)–assisted colonoscopy for colorectal cancer (CRC), the third most common cause of cancer mortality in the United States. The systematic data review is a collaboration between the…

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How the Healthcare Industry Can Soften Blow from Medicaid Cuts

Pedram Afshar , 2025-04-16 13:19:00 According to the nonpartisan Congressional Budget office (CBO), 93% of non-Medicare spending goes to Medicaid and the Children’s Health Insurance Program (CHIP). During the next 10 years, these two programs will cost more than $8.2 trillion. The proposed federal plan intends to cut $880 billion — more than 10% of Medicaid and…

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What can we do about H5N1 bird flu in cats?

Torie Bosch , 2025-04-16 08:30:00 In 2024, as zoos were hit hard by H5N1 bird flu, big cats were particularly affected: tigers, lions, a cheetah, and a panther all died after being infected with the same virus that has caused egg prices to skyrocket. House cats are vulnerable to H5N1, too, as Meghan F. Davis,…

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Outpatient services need modernising to reduce waiting lists, says report

Matthew Limb , 2025-04-16 11:21:00 NHS outpatient care is “archaic, disjointed, and inefficient” and needs radical reform to bring down waiting lists, the Royal College of Physicians and the Patients Association have said.1 The two organisations said in a joint report that the current approach to providing planned clinical investigations, tests, treatments, and diagnoses confuses…

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Atelerix signs exclusive agreement with MineBio to establish distribution channel for non-cryogenic cell preservation solutions in China

, 2025-04-16 08:58:00 Atelerix, a biotech company revolutionizing cell preservation and biological transport with its pioneering hydrogel encapsulation technology, today announced it has signed an exclusive distribution agreement with MineBio, a leading Chinese supply chain and logistics organization. Under the terms of the agreement, MineBio will act as the sole distribution partner for Atelerix’s products…

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Repurposed Antidepressant Effective for Narcolepsy

, 2025-04-16 09:12:00 SAN DIEGO — The investigational drug AXS-12 (reboxetine, Axsome Therapeutics) is safe and effective for the treatment of cataplexy (emotionally induced muscle weakness) and excessive daytime sleepiness (EDS) in patients with narcolepsy, a new study suggested.  Reboxetine was available previously in the United States as an antidepressant, but its preliminary approval was…

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How To Walk For A Steady Beat

, 2025-04-16 07:42:00 Walking is considered one of the best forms of exercise for heart health. Researchers now say, it’s not just how much you walk but the pace at which you stride also counts when it comes to heart rhythms. A recent study published in the journal Heart suggests that not just walking but…

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Consultant Intensivist – Altnagelvin Area Hospital 

brendan , 2025-04-16 07:00:00 Western Health and Social Care Trust Consultant Intensivist Location: Altnagelvin Area Hospital Salary: £106,424 – £139,920 per annum pro rata Ref No: 54891299 Closing date: Friday 9th May 2025 @ 3:30pm For full criteria, job description and application form for the above please visit jobs.hscni.net and apply online. A waiting list…

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Trial of pig livers as dialysis-like treatment for liver failure cleared by FDA

Associated Press , 2025-04-15 14:51:00 WASHINGTON — U.S. researchers will soon test whether livers from a gene-edited pig could treat people with sudden liver failure — by temporarily filtering their blood so their own organ can rest and maybe heal. The first-of-its-kind clinical trial has been cleared by the Food and Drug Administration, according to pig producer eGenesis,…

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New genetic clues uncovered in epilepsy drug resistance

, 2025-04-16 06:11:00 Certain common genetic changes might make some people with focal epilepsy less responsive to seizure medications, finds a new global study led by researchers at UCL and UTHealth Houston. Focal epilepsy is a condition where seizures start in one part of the brain. It is the most common type of epilepsy. Antiseizure…

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How Stress Shapes Cancer’s Course

, 2025-04-16 06:32:00 About two millennia ago, the Greek physicians Hippocrates and Galen suggested that melancholia — depression brought on by an excess of “black bile” in the body — contributed to cancer. Since then, scores of researchers have investigated the association between cancer and the mind, with some going as far as to suggest…

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University College Dublin’s 2025 Innovation Awardees announced by NovaUCD

Editorial Staff , 2025-04-15 07:20:00 Skin and wound healing research expert and entrepreneur receives the main 2025 NovaUCD Innovation Award The recipients of University College Dublin’s (UCD) annual innovation awards, which highlight successes made in areas of knowledge transfer, consultancy, entrepreneurship and the promotion of an innovation culture, by members of the UCD research, innovation…

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Trump administration halts multicenter TB study led by Harvard

Mike Damiano — Boston Globe , 2025-04-15 15:24:00 A top scientist at Harvard who has spent years unraveling the mysteries of tuberculosis woke up Tuesday morning and discovered an order from the federal government telling her to halt her research. The stop-work order from the National Institutes of Health arrived hours after the Trump administration’s antisemitism…

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When people repeatedly read sentences, they get faster and more accurate, showing the brain improves with practice

, 2025-04-16 05:20:00 Credit: Tima Miroshnichenko from Pexels Have you ever noticed yourself speeding up and getting better at repetitive tasks over time? Researchers from the Faculty of Arts at Charles University have unveiled insights into why this happens during reading tasks, revealing that it’s primarily due to genuine learning rather than mere boredom. The…

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Combat Post–Bariatric Surgery Weight Regain With GLP-1 RAs

, 2025-04-15 12:00:00 TOPLINE:  Treatment with glucagon-like peptide 1 receptor agonists (GLP-1 RAs), including liraglutide or semaglutide, for 12 months enabled patients to lose nearly all the weight they had regained after bariatric surgery. METHODOLOGY:  Researchers conducted a single-centre retrospective study to examine the efficacy and safety of 12 months of treatment with GLP-1 RAs…

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