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Evaluating hydronidone for the treatment of chronic hepatitis B-associated liver fibrosis

, 2025-04-18 18:57:00 Background and aims Liver fibrosis is a key process in the progression of chronic liver diseases. However, there are currently no drugs specifically designed to treat liver fibrosis. Our Phase 2 trial of hydronidone for the treatment of chronic hepatitis B (CHB)-associated liver fibrosis showed that adding hydronidone to entecavir resulted in…

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New FMF Recommendations Tackle Drug Resistance and Fertility

, 2025-04-18 12:10:00 A multidisciplinary team has released new evidence-based recommendations for the management of familial Mediterranean fever (FMF). Jointly endorsed by the European Alliance of Associations for Rheumatology (EULAR) and the Pediatric Rheumatology European Society, the recommendations are the first update to the 2016 EULAR guidelines. Although rare, FMF is the most common monogenic…

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Low-income patients with diabetes are more likely to experience insurance instability, researchers find

, 2025-04-18 17:35:00 Credit: Pixabay/CC0 Public Domain An Oregon Health & Science University-led study reveals that low-income adults with diabetes are more likely to go in and out of health insurance, and that insurance instability is even worse for those with complex needs. Published in the Journal of American Family Medicine, the study examined electronic…

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Lower temperatures increase the risk of gastroenteritis among Rohingya refugees in Bangladesh

, 2025-04-18 19:08:00 Colder temperatures are linked with increased risk of diarrhea among Rohingya refugees in Bangladesh, emphasizing the need for climate-sensitive health strategies in refugee settings. A new study by scientists at Hokkaido University has found that lower temperatures significantly increase the risk of gastroenteritis among Rohingya refugees living in Bangladesh’s Kutupalong and Nayapara…

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Weight Stigma Remains a Barrier to Patient Care

, 2025-04-18 12:35:00 Obesity has historically been regarded as a moral failing, and people with obesity describe being seen as deficient, lazy, and/or undeserving of respect, lacking willpower and self-discipline, and gluttonous. Negative judgments about obesity persist not only in society at large but also in healthcare settings, despite the American Medical Association’s declaration of…

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On Autism, Kennedy Turns Against Science and Reality

Tarena Lofton , 2025-04-18 22:00:00 During his first news conference as Health and Human Services secretary, Robert F. Kennedy Jr. on April 16 ticked off things he thinks kids with autism will never do, including paying taxes, holding a job, and going on a date. Kennedy’s comments go against science and reality.  This slide presentation…

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NIH halts new grant awards to universities with frozen funds

Anil Oza and Megan Molteni , 2025-04-18 21:24:00 Megan Molteni reports on discoveries from the frontiers of genomic medicine, neuroscience, and reproductive tech. She joined STAT in 2021 after covering health and science at WIRED. You can reach Megan on Signal at mmolteni.13. Embattled universities whose funding from the National Institutes of Health has been…

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Research identifies new cut-off points for overweight and obesity in male athletes

, 2025-04-18 22:10:00 Credit: Unsplash/CC0 Public Domain New research presented at this year’s European Congress on Obesity (ECO 2025, Malaga, Spain, 11–14 May) shows that the internationally recognized body mass index (BMI) cut-off points greatly overestimate overweight and obesity in male athletes. The study, from Italy, also proposes new cut-off points for overweight and obesity…

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Zinc found in glassware may impair embryo development in IVF

, 2025-04-18 19:17:00 1. Overview The research team discovered that glassware used to manipulate and culture fertilized eggs in the fields of assisted reproductive technology (ART), livestock farming, and basic research contains toxic substances that interfere with the development of fertilized eggs (embryos). The team also identified the toxic substance as zinc, and developed a…

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Complexities of Vitamin D in CKD Require Individualization

, 2025-04-18 12:57:00 When it comes to issues of vitamin D in chronic kidney disease (CKD), core certainties include that most patients with CKD have dysregulated 25-hydroxy vitamin D (25[OH]D) and nutritional supplementation can increase those levels. Beyond that, complexities abound, with evidence fraught with confounders regarding who may or may not benefit from supplementation….

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‘Usually Only Seen in Elite Bodybuilders’

, 2025-04-18 15:20:00 A TikTok video featuring a ChatGPT response has gone viral after it declared President Donald Trump‘s reported physical results “virtually impossible,” and compared them to those of elite-level bodybuilders. In a viral TikTok video posted by @coughbuddy, ChatGPT is shown analyzing Trump’s alleged physical stats—specifically, a 215-pound weight at 6’3″—and responding that…

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HealthMed, Podimetrics partner to help high-risk patients with diabetes

, 2025-04-18 17:47:00 Podimetrics, a company that helps patients with diabetes prevent serious complications, is teaming up with HealthMed, an employee health and wellness platform. HealthMed aims to integrate Podimetrics’ SmartMat technology into its portfolio of benefits intended for large employers, hospitals and municipalities. The company also provides employee wellness and mental health programs. Podimetrics’ SmartMat…

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‘Tell That to a Diabetic’

, 2025-04-18 19:37:00 As Dr. Mehmet Oz was sworn in as head of the Medicare and Medicaid Services, he encouraged Americans to reduce drug spending by simply staying healthy. “It is your patriotic duty — I’ll say it again — the patriotic duty of all Americans to take care of themselves,” Oz said during the…

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Why One Healthcare Founder Never Took Venture Capital

Katie Adams , 2025-04-18 19:20:00 The digital health funding market has been way up and way down over the past five years. As this roller coaster starts to settle down, one thing is clear to Randy Bolyga: that the industry is shifting toward prioritizing profitability over aggressive expansion. Bolyga is the CEO of medical software…

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GLP-1 therapies show potential for treating rare genetic disorder Bardet-Biedl syndrome

, 2025-04-18 17:35:00 Credit: Monell Chemical Senses Center A Monell Chemical Senses Center study published this week in the Journal of Clinical Investigation offers renewed hope for individuals living with Bardet-Biedl Syndrome (BBS), a rare genetic disorder characterized by early-onset obesity, compulsive eating, and cognitive impairments. The Monell team and colleagues identified that GLP-1 receptor…

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Neural fingerprints reveal how teamwork and deep focus interact

, 2025-04-18 17:26:00 Summary: A collaborative study by researchers from Toyohashi University of Technology and California Institute of Technology (Caltech) introduces a groundbreaking algorithm that maps individual brain activity in a multi-dimensional space. This “neural fingerprint” reveals stable, long-term neural traits that interplay with transient brain states during social interactions. The study demonstrates that individuals…

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Dupilumab Approved for Chronic Spontaneous Urticaria

, 2025-04-18 17:06:00 The US Food and Drug Administration (FDA) has approved dupilumab for the treatment of chronic spontaneous urticaria (CSU) in patients aged 12 years and older who “remain symptomatic despite H1 antihistamine treatment,” according to a press release from the manufacturers, Regeneron Pharmaceuticals and Sanofi.  Approval follows the FDA’s request in October 2023…

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RFK Jr. Is Giving Families ‘False Hope’ By Claiming He’ll Figure Out Cause of Autism by September, Former FDA Vaccine Head Warns

, 2025-04-18 15:22:00 Dr. Peter Marks, the former top vaccine official at the U.S. Food and Drug Administration (FDA), has criticized Health and Human Services Secretary Robert F. Kennedy Jr. for giving what he called “false hope” to families by claiming that the Trump administration will identify the cause of autism by September. Marks, who…

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Medical Device Right to Repair is the Wrong Approach

Peter J. Pitts , 2025-04-18 13:55:00 Americans are becoming more familiar with the right to repair movement that is shaking up industries from agriculture to consumer electronics. The notion is that consumers should be empowered to hire whoever they want to fix their own technologies, regardless of expertise or oversight. In fact, as of 2025…

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Eli Lilly, Novo Nordisk, FDA, Makary, GSK

Meghana Keshavan , 2025-04-18 13:02:00 Want to stay on top of the science and politics driving biotech today? Sign up to get our biotech newsletter in your inbox. Morning! Today we talk about Eli Lilly’s stock jumping after it released new data on its GLP-1 pill, see Sanofi partner with a mysterious company, and more. A very…

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Bruker introduces nVista 2P miniature microscope

, 2025-04-18 10:48:00 Bruker Corporation today announced the launch of the nVista 2P miniature, two-photon microscope, a groundbreaking addition to the Inscopix product line for functional imaging of freely behaving animals. It leverages advanced two-photon fluorescence microscopy technology to enable high-resolution imaging at greater depths with 3D data reconstruction, providing researchers with unprecedented insights into neuronal activity. Featuring several…

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FDA Authorizes First Digital Therapeutic for Migraine

, 2025-04-18 13:29:00 The US Food and Drug Administration (FDA) has granted marketing authorization to CT-132 (Click Therapeutics), an adjunctive, first-in-class prescription digital therapeutic for the preventive treatment of episodic migraine in adults, its development company announced in a statement. The mobile smartphone app uses biological, psychologic, and behavioral approaches to target pain processing and…

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We’re reading about FDA layoffs, pharma tariffs

Ed Silverman , 2025-04-18 13:54:00 And so, another working week will soon draw to a close. Not a moment too soon, yes? This is, you may recall, our treasured signal to daydream about weekend plans. Our agenda is still shaping up. We expect to promenade with the official mascots and catch up on our reading, and…

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Why insurance companies are denying coverage for prosthetic limbs

, 2025-04-18 12:13:00 Why insurance companies are denying coverage for prosthetic limbsPlay PBS News Weekend’s Ali Rogin spoke with KFF Health News contributor Michelle Andrews about what some people with missing limbs consider a disparity in health insurance coverage: Though a knee replacement likely would be covered, a prosthetic knee isn’t always. A prosthetic device…

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Wildfire Smoke Linked to Increase in Mental Health ED Visits

, 2025-04-18 13:21:00 TOPLINE: Exposure to fine particulate matter (PM2.5) from the 2020 California wildfires was linked to an increase in mental health-related emergency department (ED) visits within 7 days of exposure, including increases of 8% for all-cause mental health, 15% for depression, and 29% for other mood-affective disorders, a new study showed. METHODOLOGY: Data…

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When Patients Win,  Everyone Wins

Suzanne Harris , 2025-04-18 13:00:00 If someone asked if your company or product was patient-centric, you would likely respond with an enthusiastic yes. Let’s probe a bit deeper… When was the last time you asked a patient to contribute to trial design? Have you ever asked a patient to contribute to a protocol? If you’re…

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