Isabella Hornick , 2025-04-21 11:42:00 April 21, 2025 3 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process…
Adam Feuerstein , 2025-04-21 11:00:00 Adam Feuerstein is a senior writer and biotech columnist, reporting on the crossroads of drug development, business, Wall Street, and biotechnology. He is also a co-host of the weekly biotech podcast The Readout Loud and author of the newsletter Adam’s Biotech Scorecard. You can reach Adam on Signal at stataf.54….
, 2025-04-21 11:14:00 Credit: The FASEB Journal (2025). DOI: 10.1096/fj.202402942R A protein that stops cells from dividing in response to damage or stress could be a new biomarker or therapeutic target for metabolic dysfunction-associated steatotic liver disease (MASLD), according to research published in The FASEB Journal. The protein, called cyclin-dependent kinase inhibitor 1A (CDKN1A), was…
, 2025-04-21 10:46:00 California has halted a court-ordered medical parole program, opting instead to send its most incapacitated prisoners back to state lockups or release them early. The unilateral termination is drawing protests from attorneys representing prisoners and the author of the state’s medical parole legislation, who say it unnecessarily puts this vulnerable population at…
, 2025-04-21 10:26:00 Despite guidelines stating otherwise, clinicians continue to prescribe inappropriate antibiotics to hospitalized patients with skin and soft tissue infections (SSTIs), raising costs and increasing the risk for drug-resistant organisms. A new study has found that computer-assisted recommendations, coupled with targeted best practices, significantly reduce the use of extended-spectrum antibiotics, all without increasing…
, 2025-04-21 09:32:00 Born twice? It sounds impossible, but that’s exactly the story of miracle baby Rafferty Isaac in the U.K. At just 20 weeks, he was temporarily removed while in the womb so doctors could perform life-saving surgery on his mother, who had been diagnosed with ovarian cancer. After the complex five-hour procedure, Rafferty…
Don Thompson , 2025-04-21 09:00:00 SACRAMENTO, Calif. — California has halted a court-ordered medical parole program, opting instead to send its most incapacitated prisoners back to state lockups or release them early. The unilateral termination is drawing protests from attorneys representing prisoners and the author of the state’s medical parole legislation, who say it unnecessarily…
Josh Friedman , 2025-04-21 09:00:00 April 21, 2025 6 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process…
Andrew Joseph , 2025-04-21 08:30:00 The hulking factories are tucked away off the roads around the village of Ringaskiddy — operated by the likes of Pfizer, Johnson & Johnson, and BioMarin, whose plant featured signs last week touting a new facility “coming Q1 2027.” The nearby town of Carrigtwohill crows that it’s grown “+400% over…
, 2025-04-21 09:00:00 Credit: Unsplash/CC0 Public Domain Older adults with cancer respond just as well as younger patients to immune checkpoint inhibitors despite age-related immune system differences, according to a study by researchers from the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy, and the Johns Hopkins Convergence Institute. Most new…
, 2025-04-21 09:04:00 TOPLINE: A recent study found that the homeostasis model assessment insulin resistance (HOMA-IR), quantitative insulin-sensitivity check index (QUICKI), and fasting glucose/insulin ratio (FGIR) were stronger predictors of insulin resistance than the triglyceride glucose index (TyG) in children with overweight or obesity. METHODOLOGY: Researchers conducted a single-center retrospective study to establish the correlation…
, 2025-04-21 08:32:00 Three cases of Creutzfeldt-Jakob Disease (CJD), a rapidly progressing illness that leads to dementia and death, have been reported in Oregon, officials revealed. Source link
Hala Durrah , 2025-04-21 08:30:00 Democrats recently unveiled a campaign to recruit and elect 100 doctors to public office. Democrats hope that by recruiting physicians to public office, they will be able to combat misinformation and restore trust in medicine and science. Amid a full-blown measles outbreak, the U.S. plan to withdraw from the World…
, 2025-04-21 07:31:00 The Layer 7 Cortical Interface is a high-resolution cortical electrode array for use in recording, monitoring, and stimulating electrical activity on the surface of the brain. Medscape Medical News Source link
, 2025-04-21 07:16:00 TOPLINE: In patients with nasopharyngeal carcinoma who received induction-concurrent (chemo)radiotherapy, persistent Epstein-Barr virus (EBV) DNA positivity or its resurgence during treatment was associated with worse survival outcomes, whereas rapid clearance of EBV DNA following induction chemotherapy was associated with better survival. METHODOLOGY: Plasma EBV DNA is the most widely used biomarker for…
, 2025-04-21 07:04:00 Amid growing fears over a surge in measles cases in Texas, a video circulating online has sparked outrage after it showed a doctor with a measles rash treating children. Public health experts have raised alarms about the potential spread, condemning the doctor who continued to practice while being infected with the highly…
, 2025-04-21 06:24:00 The story of how Erin McKean, MD, ended up in, as she puts it, the “weird small niche field” of minimally invasive, ventral skull base surgeries — operating on sinonasal cancers and pituitary tumors for instance — might never have happened had she not met her mentor. The first in her family…
, 2025-04-21 06:30:00 The Centers for Disease Control and Prevention confirmed its first US case of COVID-19 in early 2020, and 8 months later the World Health Organization described a post-viral condition called long COVID. Since then, millions of Americans, around 8% of those with acute COVID, have also been identified as having long COVID….
, 2025-04-21 06:21:00 Immanuel Hoxobeb assists Alicia who participates in the “Enabling Through the Horse,” therapy program outside Windhoek, Namibia, on Feb. 18, 2025. Credit: AP Photo/Dirk Heinrich Susan de Meyer’s horses have different effects on different children. Hyperactive kids learn to be a little quieter around them while nonverbal children are moved to communicate…
, 2025-04-21 05:33:00 TOPLINE: The Global Burden of Disease (GBD) Study 2021 reported 44.84 million disability-adjusted life years (DALYs) because of skin and subcutaneous diseases. METHODOLOGY: Researchers utilized data from the GBD Study 2021 to examine incidence, prevalence, and DALYs for 371 diseases and injuries across 204 countries and territories from 1990 to 2021. Skin…
, 2025-04-21 05:13:00 Right after residency, Maryland-based hospitalist Anisha Bassi, MD, took on a 7 days on/7 days off shift. She worked 12-hour days, and if she wanted to boost her income, she would add in an overnight, or a 4 AM to noon. It was tiring, she said, but she was young, and it…
, 2025-04-21 04:10:00 Credit: Pixabay/CC0 Public Domain “Tusi,” also known as “tucibí” or “pink cocaine,” is a drug concoction that emerged in Latin America and Europe within the past decade and is becoming increasingly popular in the U.S. A study published in Addiction estimates that in 2024, 2.7% of electronic dance music nightclub-attending adults in…
, 2025-04-21 02:50:00 TOPLINE: A panel of dermatologists reached a consensus on 23 topical ingredients that they considered useful for seven common skin concerns, with retinoids recommended for five of those conditions. METHODOLOGY: A literature review (1990-2020) identified 318 discrete cosmetic ingredients, which were then evaluated by 17 expert dermatologists who were either program directors…
, 2025-04-20 16:47:00 A deeper understanding of osteosarcoma, the most common primary malignant bone tumor affecting children and adolescents, is reshaping strategies for overcoming treatment resistance. Central to this breakthrough is Nuclear factor E2-related factor 2 (Nrf2), a transcription factor now recognized as a pivotal player in chemoradiotherapy resistance. Traditionally acknowledged for its role in…
, 2025-04-20 17:04:00 Lipid metabolism has emerged as a central player in the progression and therapy resistance of breast cancer, particularly the aggressive subtype known as triple-negative breast cancer (TNBC). This review article highlights how disruptions in lipid regulation can significantly influence the behavior of breast cancer cells, impacting their growth, metastasis, and response to…
, 2025-04-20 17:19:00 A new review published in Genes & Diseases highlights the transformative role of microRNAs (miRNAs) in regulating and potentially reversing adipose tissue fibrosis, a condition closely linked to obesity, diabetes, and cardiovascular disease. Fibrosis, driven by abnormal extracellular matrix (ECM) accumulation, disrupts normal adipose tissue function and contributes to broader organ dysfunction….
, 2025-04-20 18:49:00 by Jeffrey Lo, MD, Attending Physician, Orthopedics and Sports Medicine Department, Boston Children’s Hospital When a child tumbles to the floor from a blow to the head, a parent’s inner alarms should sound. The child may have a brain injury. Here’s what parents need to know: What is a concussion? A concussion…
, 2025-04-20 17:36:00 Anaplastic thyroid cancer (ATC), a rare yet highly aggressive malignancy, continues to represent a major clinical challenge. A recent review published in Genes & Diseases offers a comprehensive overview of the molecular mechanisms, diagnostic approaches, and therapeutic strategies driving current and future management of this lethal disease. ATC, accounting for a small…
, 2025-04-20 18:51:00 Credit: Pixabay/CC0 Public Domain The head of the hospital service on the French Indian Ocean island of Reunion on Sunday called for medical reinforcements to cope with an epidemic of the mosquito-borne chikungunya disease. “We are really stretched to our limits,” Lionel Calenge told the RMC radio station. “Epidemiologists predicted the epidemic…
, 2025-04-20 17:42:00 A recent publication in Genes & Diseases has delivered a compelling synthesis of the latest insights into the cellular mechanisms and therapeutic interventions for achondroplasia, the most common form of genetic dwarfism. This disorder stems primarily from gain-of-function mutations in the fibroblast growth factor receptor 3 (FGFR3) gene, which exerts widespread effects…
, 2025-04-20 17:57:00 Researchers from Tokyo Metropolitan University have found that the motion of unlabeled cells can be used to tell whether they are cancerous or healthy. They observed malignant fibrosarcoma cells and healthy fibroblasts on a dish and found that tracking and analysis of their paths can be used to differentiate them with up…
Frank Vinluan , 2025-04-20 18:05:00 Sanofi and Regeneron Pharmaceuticals drug Dupixent has won FDA approval for chronic spontaneous urticaria, introducing a new approach to the treatment of this inflammatory skin disorder. It’s the seventh FDA approved indication for the blockbuster product. The regulatory decision announced Friday covers the treatment of patients age 12 and older…
, 2025-04-20 17:49:00 In popular culture, dads are stoic, sensitive and strong. So powerful is the mystique of the happy dad that celebrities, joke books – even hard seltzers – carry the label. Real life is different. Fathers get down, sometimes debilitatingly. And as new research from Rutgers Health reveals, when paternal depression goes undiagnosed…
, 2025-04-20 17:32:00 A new wave of scientific interest is spotlighting GOT2—glutamic-oxaloacetic transaminase 2—as a compelling therapeutic target in the fight against pancreatic cancer, one of the most lethal and treatment-resistant malignancies. This mitochondrial enzyme, deeply embedded in glutamine metabolism, plays a central role in sustaining cancer cell survival and growth. By regulating the malate-aspartate…
, 2025-04-20 17:07:00 Citrullination, a transformative protein post-translational modification, is gaining recognition for its wide-ranging impact on cellular function and human disease. This process, driven by the enzyme family known as peptidyl arginine deiminases (PADs), converts the amino acid arginine into citrulline, neutralizing its charge and fundamentally altering protein structure and behavior. Among its most…
, 2025-04-20 16:57:00 In a transformative review, small noncoding RNAs (sncRNAs) have emerged as pivotal regulators in the complex landscape of cardiovascular diseases. These RNA molecules, which do not encode proteins, were long overshadowed by their well-studied counterparts such as microRNAs. However, new insights highlight the substantial biological impact of lesser-known sncRNA subclasses including transfer…
Katie Adams , 2025-04-20 13:44:00 The healthcare industry has faced a flurry of sweeping changes at the federal level since President Donald Trump took office. In recent months, healthcare leaders have scrambled to come up with strategies to address proposed Medicaid cuts, slashed research funding and the dismantling of the country’s public health infrastructure. Now,…
Houda Hachad , 2025-04-20 13:47:00 Genomic medicine leverages an individual’s genetic information to guide healthcare decisions, with drug-gene testing (also known as pharmacogenomics, or PGx) being a key application that personalizes medication needs based on genetics. Although PGx testing offers a more precise, personalized approach to prescribing medications more safely and effectively, benefiting both patients…
Barbara Levy , 2025-04-20 13:50:00 Women’s health has been historically sidelined – underfunded, underresearched and often misunderstood. While interest and investment around complex women’s health have increased, we’re still a long way away from delivering meaningful outcomes to women at scale. Case in point: Endometriosis is a debilitating and life-limiting condition that impacts 1 in…
, 2025-04-20 13:50:00 Japanese FC-RAT. The sequence of events within a single trial in the Fixation condition (top row) and the Neutral condition (bottom row). In both conditions, participants receive a question and are instructed to press a button once they have come up with an answer. Following this, they provide their answer; if it…
Marissa Plescia , 2025-04-20 13:13:00 UnitedHealth Group took quite the tumble on Thursday and Medicare Advantage troubles seem to largely be at fault. Its shares fell by over 22% after its first quarter earnings on Thursday. This is the Minnetonka, Minnesota-based company’s largest single-day drop since 1998. The healthcare giant also revised its adjusted earnings…
, 2025-04-18 14:50:00 Graphical abstract. Credit: Cell (2025). DOI: 10.1016/j.cell.2025.01.041 Understanding and treating brain disorders such as tremor, imbalance, and speech impairments requires deep knowledge of the cerebellum, a part of the brain that’s crucial for making accurate movements. Scientists have long been able to eavesdrop on and record the electrical signals transmitted by neurons…
, 2025-04-18 15:00:00 Credit: Unsplash/CC0 Public Domain Both the use of next-generation sequencing (NGS) testing for cancer and the rate of claim denials for such testing increased between 2016 and 2021, despite implementation of a recent Medicare national coverage determination that established coverage standards for NGS testing. The analysis by Georgetown University researchers and colleagues…
, 2025-04-19 16:40:00 Credit: Pixabay/CC0 Public Domain CT scans are a vital part of modern medicine. Found in every hospital and many clinics, they give doctors a fast and detailed look inside the body—helping to diagnose everything from cancer and strokes to internal injuries. But a new study suggests there may be a hidden cost…
, 2025-04-18 15:05:00 Credit: Pixabay/CC0 Public Domain Our immune systems weaken as we get older, making fewer cells that fight infection and help us recover from illness and injury. Scientists aren’t completely sure why. They may have a better idea now, however, thanks to a study in GeroScience. “Immune cell changes occur during aging for…
, 2025-04-18 15:55:00 Identifying areas of active gene regulation in IMR90 cells expressing MCPyV T antigens. Credit: Journal of Clinical Investigation (2025). DOI: 10.1172/JCI177724 A common pinworm medication may stop and reverse cancer growth in Merkel cell carcinoma, an aggressive form of skin cancer, according to research led by University of Arizona Cancer Center researchers…
, 2025-04-18 15:57:00 Credit: CC0 Public Domain Even after surgery, injuries to the anterior cruciate ligament (ACL) often lead to chronic pain and reduced mobility, with limited options for treatment. New research suggests that advances in knowledge and therapeutics may come from an unlikely source: dogs. In a study published April 18 in the Journal…
, 2025-04-18 16:12:00 In vivo imaging of U-87 MG xenograft model with varying mass doses of 89Zr-labeled KLG-3 or isotype control. (A) Representative maximum-intensity projection (MIP) and axial PET/CT images at 144 h after injection. (B) Tumoral uptake ([%ID/g]max). (C) Blood clearance ([%ID/g]mean). (D) TNR of 5, 10, and 30 µg at 144 h after…
, 2025-04-18 16:18:00 Kutupalong refugee camp in Cox’s Bazar, Bangladesh. (Photo: Takuya Takata). Credit: Takuya Takata A new study by scientists at Hokkaido University has found that lower temperatures significantly increase the risk of gastroenteritis among Rohingya refugees living in Bangladesh’s Kutupalong and Nayapara camps. Gastroenteritis is a viral or bacterial infection that causes inflammation…
, 2025-04-18 16:19:00 Credit: Tima Miroshnichenko from Pexels For people living with primary progressive aphasia (PPA), a rare, early-onset neurodegenerative dementia that predominantly affects language abilities, something as simple as ordering their favorite meal at a drive-thru can be a deeply meaningful marker of independence. Led by experts at the University of Chicago’s Healthy Aging…